FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products: Early Phase Trials Using Innovative Trial Designs and Biomarkers url: aacrjournals.org/clincancerre...

FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products: Selecting Optimized Dosages for Registrational Trials url: aacrjournals.org/clincancerre...

FDA-AACR Strategies for Optimizing Dosages for Oncology Drug Products: Selecting Dosages for First-In-Human Trials url: aacrjournals.org/clincancerre...

Check out these articles in CCR.

Sign up to receive alerts directly to your inbox to keep up with the latest published issues: buff.ly/O6OYSDp

Joseph C. Murray, MD, PhD, recipient of the 2025 Clinical Cancer Research Early Career Award, speaks about the questions that drive his research. To learn more, watch the full interview: buff.ly/fa085VG

Check out Editors' Picks from the July issues, covering cancer mortality hotspots in the US, the mechanisms of chemotherapy-induced hearing loss, and how AI might help pair patients with the right therapy and predict combination therapies that can prevent cancer escape. buff.ly/yK3WqW5

👉 Recently published in Clinical Cancer Research: A population-level real-world analysis and single-center validation of melanoma brain metastasis epidemiology following dual-agent immunotherapy 🔗 doi.org/10.1158/1078... #EANOessentials #NeuroOncology #BrainMetastases #brainMets #medsky

If you are attending #AACRai25, meet the AACR Journals’ editors during breakfast on Friday, July 11th from 7AM – 8AM, featuring Kevin Burton, PhD, of Cancer Research, Emily Frieben, PhD, of Cancer Research Communications, and Tali Lev, PhD, of Cancer Discovery.

Image of a metastatic lymph node from a patient with oral squamous cell carcinoma. Multiplex immunohistochemical staining highlights the spatial interplay of PERK+ macrophages, activated fibroblasts & tumor cells in an immunosuppressive niche. Article by Zhang et al. aacrjournals.org/clincancerre...

This snazzy image shows a region of pancreatic cysts, intraductal papillary mucinous neoplasms. The authors performed digital spatial transcriptomic profiling & found distinct indolent & malignant transcriptomic states. For more detail, see the article by Iyer et al. aacrjournals.org/clincancerre...

On day 4 of #AACR25 researchers shared data on combining liquid and tissue biopsies for tailored therapy selection, a decrease in breast cancer mortality, and clinical trial results for antibody-based therapies. Read more takeaways on the #AACRBlog: www.aacr.org/blog/2025/04...

Today is the day!!! Come by the #AACR25 booth to meet myself and Editor-in-Chief, Timothy Yap for Clinical Cancer Research. 2:00, booth #2615.

This is a potential game changer for many cancers.

Congratulations to Joseph C. Murray, MD, PhD, recipient of the 2025 Clinical Cancer Research Early Career Award, which recognizes the outstanding contributions of #earlycareer investigators. Learn more: brnw.ch/21wSfdm @hopkinspress.bsky.social @theaacr.bsky.social #AACR25

Congratulations Sandra Misale! @sandramisale.bsky.social! It was nice meeting you last night. #AACR25

Check out this thread from @seplon.bsky.social and then go see the pediatric cancer series here brnw.ch/21wSeVa #AACR25

If you enjoyed the session “Cancer Predisposition in Childhood Cancer: Implications for Prevention, Surveillance, Interception, and Survivorship Care ", then check out the recent series on the topic in Clinical Cancer Research. #AACR25 brnw.ch/21wSeVa

Just before landing in Chicago, above a sea of fluffy clouds. #AACR25

Are you attending #AACR25 and are thinking about submitting your work to Clincal Cancer Research? Come meet the Editor-in-Chief, Timothy Yap and Executive Editor, Marlowe Tessmer at South Hall A1-2 Booth 2615 Monday 4/28 at 2:00PM. Or contact us to discuss your research. See you in Chicago.

Hot off the press in Clinical Cancer Research - ctDNA Clearance as an Early Indicator of Improved Clinical Outcomes in Advanced NSCLC Treated with TKI: Findings from an Aggregate Analysis of Eight Clinical Trials aacrjournals.org/clincancerre...

The cover shows a portion of a gastric cancer biopsy from a HER2+ patient. For details, see the article by Lim and colleagues on page 1476 of this issue of Clinical Cancer Research.

When you are planning your itinerary for #AACR25, don't forget to contact me and schedule a time so we can talk about submitting your work to Clinical Cancer Research or any questions that you have about the Journal. See you in Chicago!

The cover shows adjacent normal rectal tissue that was fixed and stained with antibodies to Ki-67 (green) and K-18 (red) with DAPI (blue). For more information, see the article by Chaudhary and colleagues in this issue of Clinical Cancer Research.

March is #MultipleMyelomaAwarenessMonth. AACR Project GENIE offers valuable insights into the genomic landscape of multiple myeloma, with 1,167 patients and 1,548 sequenced tumor samples. #AACRGENIE: www.aacr.org/professional... Powering the future of precision oncology.

Before you come see The CheckPoints perform at the #AACR25 Annual Reception in Chicago next month, learn more about each of the cancer researchers and oncologists who make up this cover band: www.aacr.org/blog/2025/03... #AACRBlog

This cover shows the localization of MUC16 in the membrane & cytoplasmic compartments of a renal medullary carcinoma cell. DNA is blue, MUC16 is green, & actin is red, with merged MUC16 & actin appearing as yellow. For details, see the article by Grimm & colleagues on page 1057 of this issue of CCR.

Today is #InternationalWomensDay. Through grants, education and training, and our Women in Cancer Research constituency group, the AACR is committed to inspiring and advancing #WomenInScience. Learn more: buff.ly/8UfcvFz

The AACR is proud to announce our newly elected class of Fellows of the AACR Academy. The AACR Academy honors distinguished scientists whose contributions have propelled significant innovation and progress against cancer. Learn more: buff.ly/8a8WUn9 #AACRFellows

The Week in Cancer News: The number of lesions that can lead to cervical cancer has dropped 80% since the introduction of HPV vaccines, the FDA approved a monoclonal antibody to treat esophageal cancer, and more. buff.ly/V4PNnFu

Just out in Clinical Cancer Research - A novel combination of Zanubrutinib plus Ixazomib and Dexamethasone in newly diagnosed symptomatic Waldenström macroglobulinemia from a phase II clinical trial aacrjournals.org/clincancerre...

The authors evaluate the paradigm for dietary supplement marketing & FDA approval & its impact on the treatment of cancer patients. Integrating Botanicals into Oncology Care: Consideration of FDA Regulation of Botanical Products and Botanical Clinical Trials aacrjournals.org/clincancerre...

This cover image shows staining of MUC5AC (green) colocalizing with cMET (red) in breast cancer brain metastatasis. Data suggests a new potential therapeutic target. For details, see the article by Maurya & colleagues in the March 1 issue of Clinical Cancer Research. aacrjournals.org/clincancerre...

Cool cover image showing a turmor section from a patient with advanced head & neck squamous cell carcinoma. Immunohistochemical staining highlights the tumor microenvironment spatial architecture & various immune cell populations surrounding the tumor. See the article by Hanna and colleagues in CCR.

Clinical Trial of EBNA1 Inhibitor, VK-2019, in Patients with Epstein-Barr–Positive Nasopharyngeal Cancer with Pharmacokinetic & pharmacodynamic shows an acceptable safety profile, and on-target biological activity in tumors from advanced EBV-positive NPC patients. aacrjournals.org/clincancerre...

Antitumor Activity and Biomarker Analysis for TROP2 Antibody–Drug Conjugate Datopotamab Deruxtecan in Patient-Derived Breast Cancer Xenograft Models @mdanderson.bsky.social @theaacr.bsky.social aacrjournals.org/clincancerre...

The cover shows a section of a breast tumor. Staining shows cell-surface expression of antibody-drug conjugate target TROP2 (tumor-associated calcium signal transducer 2). For details, see the article by Meric-Bernstam and colleagues on page 573 of this issue of CCR. aacrjournals.org/clincancerre...

ICYMI in CCR Novel trial w/promising clinical activity suggests that low-dose nab-paclitaxel+tislelizumab might be a promising regimen for high-risk superficial bladder cancer, especially patients that are poor candidates for cystectomy or declined radical cystectomy aacrjournals.org/clincancerre...

February is National Cancer Prevention Month!

The cover shows a section of a CODEX image from a patient with recurrent glioblastoma. Prior to PD-1 blockade plus re-irradiation treatment, T cells localize in the perivascular space, whereas after treatment, they migrate deeper into the tumor. Article by Iwamoto. aacrjournals.org/clincancerre...

Hot off the press at CCR - Olaparib, temozolomide and concomitant radiotherapy for partially or biopsy-only glioblastoma first-line treatment: results from the OLA-TMZ-RTE-01 phase 1 study aacrjournals.org/clincancerre...

Phase II Open-Label Trial of Brentuximab Vedotin with Pembrolizumab in PD-1–Pretreated Metastatic Non–Small Cell Lung Cancer and Metastatic Cutaneous Melanoma aacrjournals.org/clincancerre...

The latest episode of Believe in Progress takes you inside the 2024 AACR @Philly_Marathon with Jim Marino, Bill Rodgers, Rachael Ringer, Todd Wiseman, and Coleen McMahon, sharing inspiring stories of resilience and advocacy in the fight against cancer. Listen here: www.youtube.com/playlist?lis...

AACR President-Elect Lillian Siu, MD, FAACR, explains how precision medicine could advance in 2025, including a new era for drugging the undruggable, better predicting treatment response, and more: www.aacr.org/blog/2025/01...

The cover shows a tumor section from a patient w/pancreatic ductal adenocarcinoma. Staining depicts an immunogenic tumor microenvironment w/high counts of CD3+ (yellow) and CD8+ (green) tumor-infiltrating lymphocytes & decreased counts of CD68+ macrophages (orange). aacrjournals.org/clincancerre...

Research is the cornerstone of progress in cancer science and medicine. The AACR was honored its President, Dr. Patricia M. LoRusso, joined other global leaders at the White House last Friday for a pivotal Global Cancer Fund meeting to discuss partnerships to reduce the global burden of cancer.

Out today in Clinical Cancer Research - Safety and Tolerability of Letetresgene Autoleucel (GSK3377794): Pilot Studies in Patients with Advanced Non–Small Cell Lung Cancer aacrjournals.org/clincancerre...

Phase 1/2 Study of the Indoleamine 2,3-Dioxygenase 1 Inhibitor Linrodostat Mesylate Combined with Nivolumab or Nivolumab and Ipilimumab in Advanced Solid Tumors or Hematologic Malignancies @joseptabernero.bsky.social aacrjournals.org/clincancerre...

Apply for the CD award as well!

Last call—nominations for the Clinical Cancer Research Early Career Award are open until January 10, 2025. Submit a nomination before time runs out! bit.ly/3BW58RP