A beautiful Christmas Eve morning in #pittsburgh today with buildings downtown lit up red and green for the holidays. Sunrise was incredible as well from the West End Overlook, capping off what was a great start to the day.

happy halloween i am ready to confuse some trick-or-treaters

Sigh. We're gonna need a bigger story...

I just voted for this kit as well! This is an amazing design, and it needs 10k votes for that the kit to be produced and sold! Friends, I need one for my lab. I'll buy one for my team if this model gets the votes.

I am super excited to announce that we have a tenure-track faculty position in biophysics open in the Department of Physics at Carnegie Mellon! 🧪 Interfolio link: apply.interfolio.com/174360 PLEASE, share widely across the blue skies! Let me briefly explain what we're looking for: 1/10

Nabarun Dasgupta was recognized with a MacArthur "genius" award for work studying the deadly overdose crisis. He's also a front-line organizer, helping people survive.

What a great idea!! See solution for puzzle #376 with 84 walls!

I completed #Celtix 372 using 92 walls. www.andrewt.net/puzzles/celt...

🧬 I know I should save this model for the official #RNAday in August, but this #DNAday, did you know that the i-motif is two interdigitated duplexes?? This thing is wild and beautiful. 3D printable model of the RNA i-motif (PDB 1I9K) shown below.

In honor of #DNAday, here is a 3D printable model of a g-quadruplex (PDB 139B) separated into a few layers, showing the non-canonical binding that makes the g-quadruplex possible.

Insanely beautiful insights into Nature's own RNA origami!

Cut out and make hearts by www.instagram.com/hakoyamaho

How to spend today

Finally got my first 8-wall-game on #Celtix! So tell me Celtix folks, was this an easy one? (Yesterday’s demolished me). I completed #Celtix 213 using 8 walls. www.andrewt.net/puzzles/celt...

A.J. Vetturini's generative design framework generates sets of wireframe DNA origami nanostructures without the need for a predefined mesh. This tool supports multi-objective optimization inputs to represent critical tradeoffs in effective nanostructure design! doi.org/10.1093/nar/... 2/2

Two exciting new papers out over break! Taryn Imamura shows how tuning the surface energy of a templating array improves pocketing yields 100 fold, enabling the assembly of even more complex DNA nanostructure-linked microrobots that are modular, complex and flexible. doi.org/10.1002/admt... 1/2

I'm not sure what makes me more frustrated: (1) the stark state-to-state variation in structural sexism, (2) the association between structural sexism and late life memory loss in women or (3) the terrible line spec choices in Figure 1 with this bombshell data. www.cuimc.columbia.edu/news/sexism-...

Never gotten below 9 walls, but it’s always great to get #Celtix in 9! Hooray! www.andrewt.net/puzzles/celt...

I mostly fixed this dude tonight!

Good news on a H5N1 vaccine efficacy in a preclinical model in case it is needed science.org/doi/10.1126/...

🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov

The new 2024 game I'm most thankful for is a spatial logic puzzle called Celtix www.andrewt.net/puzzles/celt.... Last night in some of my proudest puzzle-solving to date I managed a solution in 17 walls, and then with some tweaking I got that number all the way down to 11. Happy Thanksgiving!

Message from my dog: stay cool and do NOT create a giant todo list for the holiday break.

Who should you nominate as reviewers for your manuscript? After a long chat with a post-grad it appears that there's a lot of misguided advice out there. Thread 👇

Whoa, that's not DNA! Thanks to Dave Doty for updating scadnano.org/dev/ to allow for modified helicity in the dev fork of scadnano. Now we can design peptide nucleic acid nanostructures in the browser!

In Octavia Butler’s Parable of the Sower, the dystopian timeline begins Saturday, July 20, 2024. Tomorrow.

Still doing Celtix puzzle each day, always under 20, usually in the 14-16 range. Today I did my personal best and got #Celtix 34 in just 10 walls!

Personal best today. Completed #Celtix 12 using just 9 walls. www.andrewt.net/puzzles/celt...

OMG OMG solved #Celtix 11 with just 11 walls! I'm in shock.

Sub 20 walls for #Celtix puzzles 8 through 10! Still can't do better than 15 walls, but I'll keep trying.

4th try and I'm down to 14 walls on #Celtix 7. Huzzah!

18 walls on second try! Good thing, too, I have somewhere to be. #Celtix 7 www.andrewt.net/puzzles/celt...

Yay! I completed #Celtix 6 using 17 walls. www.andrewt.net/puzzles/celt...

Took me 5 tries to win with sub 20 walls on puzzle 5 but I did it! #celtix

Tied my current record! I completed #Celtix 4 using 17 walls. www.andrewt.net/puzzles/celt...

Can we make daily #Celtix posting a thing? Who else prefers knots over wordplay? Sub 20 walls for days 1-3!! www.andrewt.net/puzzles/celt...

AOL giving users internet access changed high school for me

University leadership everywhere has a duty of care for all of the students in their charge. A duty of care. Say it to yourself while walking if needed. They, we, should show up every day with that mission. By unleashing state violence on students, they are showing they can’t adhere to that mission.

Congratulations to C&EN for hosting such an amazing fireside chat with Priestley Medalist Carolyn Bertozzi at ACS 2024. Entire discussion is a revelation but at minute 18:42 it is absolute 🔥 www.youtube.com/watch?v=SLFj...

An effective treatment for depression from a systematic review of >200 unique RCTs: Exercise. Benefit proportional to intensity of exercise prescribed www.bmj.com/content/384/...

Based on the complexity of the DNA nanostructure models I'm weaving together, you can always tell when I have a big deadline looming.

This would have made them so much easier to learn!

@jeanmdavidson.bsky.social mentioned literally this example in her recent UNC talk about how science takes a diversity of contributors to get it right 💪

That moment when you realize the NSF won't update your proposal's status again until after holiday, but you keep checking anyway.

DOG checking out new BSKY world

As we work to build ever-smaller and more uniform micro- and nanorobots, milliscale models help us understand locomotion determinants! Buoyant magnetic milliswimmers reveal design rules for optimizing microswimmer performance - now published in Nanoscale pubs.rsc.org/en/content/a...