Come join us! 4 year PhD position in infection biology/microbiology available associated to our newly funded Clinical Academic Group “Patient-tailored management of bacterial infections in the age of antimicrobial resistance”. Applications via: www.jobbnorge.no/en/available.... @cansuit.bsky.social

Our latest work on the somewhat enigmatic serine hydrolase FphE from S. aureus is out. This work provides interesting structural and ligand binding insights that help to explain its biological functions. With @mfellnerlab.bsky.social - University of Otago. www.pnas.org/doi/10.1073/pnas.2532683123

Our latest work on fluorescent probes for imaging infections in vivo is out. Check it out! www.biorxiv.org/content/10.6...

How can we study target engagement and selectivity of covalent inhibitors? Which electrophilic probes are best suited to study a certain amino acid? Our study on "Profiling the proteome-wide selectivity of diverse electrophiles" is published in Nature Chemistry.(1/7) www.nature.com/articles/s41...

After a long journey and much hard work from many talented scientists, our paper is finally out. Take a look if you are interested in proteases and host microbe interactions in the gut. www.cell.com/cell-host-mi...

Last chance for early registration for the 2025 Chemical Biology & Physiology Symposium (Dec. 11-13 in Portland, Oregon, USA). Register here: www.ohsu.edu/school-of-me... Great program, including talks by Carasco, Chang, Bogyo, Baskin, Swarts, Sampson, Sletten, Dodani, Francis, Urano, Gibbs, etc.

Great collaboration with @derda_lab @RatmirDerda just posted to bioRxiv. Check out how to best incorporate electrophiles into cyclic peptides to generate covalent inhibitors. www.biorxiv.org/content/10.1...

Congrats to postdoc Zhe Zhou on her paper out today in @cp-cellhostmicrobe.bsky.social showing that gut bacteria cross-feed a common dietary antioxidant to produce energy under anaerobic conditions. Thanks to collaborators Angela Jiang and Xiaofang Jiang at NIH. www.sciencedirect.com/science/arti...

An inspiring paper by the group of Jacob Geri in Analytical Chemistry. They present a method for residue-specific #chemoproteomics without the need for an enrichment step. To achieve this, they developed reagents that shift the ion mobility for gas phase separation. pubs.acs.org/doi/full/10....

A new exciting article in @natbiotech.nature.com highlights the power of chemical proteomics to find druggable pockets on difficult high-value targets. Great insights into applications in covalent and non-covalent drug discovery including clinical development. (1/5) www.nature.com/articles/s41...

Congratulations to Dr. Stavroula Hatzios on this well-deserved recognition! 👏

Pleased to share our lab-optimized chapter in Methods in Molecular Biology: “Activity-Based Protein Profiling of Serine Hydrolases in Bacteria.” Thanks to @christianslentz.bsky.social . doi.org/10.1007/978-...

Our work identifying new covalent inhibitors of Staphylococcus aureus serine hydrolyses from fragment libraries is out! great work from @tulsiupadhyay.bsky.social and our many collaborators, including @christianslentz.bsky.social, @mfellnerlab.bsky.social. #chembio link.springer.com/article/10.1...

If you are interested in lipids in bacteria, check out this awesome new review written by my talented student Alyssa Carter, super postdoc Emily Woods and me. #chembio www.sciencedirect.com/science/arti...

Excited to report our studies that identified a new serine protease secreted by the gut microbe Bacteroides fragilis that regulates pain and inflammation through PAR2 activation. #ChemBio. Check it out!https://www.biorxiv.org/content/10.1101/2025.01.15.633241v1

Thanks a lot @monaj66.bsky.social 😊

Our paper. Thanks a lot @christianslentz.bsky.social 😊