Huge thanks to Chenxi Zhou for helping scale this approach to human sized genomes!

A paper from @lachlanjmc.bsky.social Lachlan Coin, not active here for the past month, on Using synthetic RNA to benchmark poly(A) length inference from direct RNA sequencing academic.oup.com/gigascience/...

Louisiana has to build three new natural gas power plants to accommodate the "AI" data center that Meta just crammed through because said center will use *Three Times* as much electricity (and, thus, attendant resources) as the *Entire City Of New Orleans*, every year. Y'all this isn't sustainable.

Today, our article "The entities enabling scientific fraud at scale are large, resilient, and growing rapidly" is finally published in PNAS. I hope that it proves to be a wake-up-call for the whole scientific community. reeserichardson.blog/2025/08/04/a...

Our latest preprint using long read nanopore sequencing to study Ferret transcriptomic response to infection and interferon stimulation, lead by Rubaiyea Farrukee and Jessie Chang www.biorxiv.org/content/10.1...

New paper from our lab in collaboration with Blaskovich lab led by former Phd student Anggia Prasetyoputri using in vitro selection to identify drug resistance conferring murations in S. aureus academic.oup.com/jacamr/artic...

New preprint from @aleixcanalda.bsky.social on structural variation in TB and its role in evolution and drug resistance www.biorxiv.org/content/10.1...

New preprint from the lab, describing an approach to enrichment of transcript isoforms for nanopore cDNA sequencing, using CRISPR-Cas9 www.biorxiv.org/content/10.1...

Customizable host and viral transcript enrichment using CRISPR-Cas9 long-read sequencing for isoform discovery and validation https://www.biorxiv.org/content/10.1101/2025.04.11.648353v1

I want to provide an overview and perspective of rare disease genomic testing, which is a real success story of science impacting health - a science which goes back over 100 years and yet is still striding forward and much more to come.

Latest preprint from the lab: we asked whether native RNA sequencing (using nanopore sequencing) might be a successor to traditional cDNA sequencing for biomarker discovery in blood.

“We don’t value software, data, and methods in the same way we value papers, even though those resources empower millions of scientists” 💯 www.statnews.com/sponsor/2024...

Genome size estimation from long read overlaps https://www.biorxiv.org/content/10.1101/2024.11.27.625777v1

🌟 Excited to share my latest preprint with @lachlanjmc.bsky.social on @biorxivpreprint.bsky.social: "Genome size estimation from long read overlaps”! 🚀 Check it out here: doi.org/10.1101/2024... And find the code here: github.com/mbhall88/lrge 🧵👇

Was inspiring to attend the TBunion conference in Bali last week and learn about the great TB research happening all over the world. Probably one of the most international conferences I have been to (in terms of number of countries represented)