David Hathcock (@davidhathcock.bsky.social)

Excited to share a new preprint! With @jiexiaolab.bsky.social, we investigated the impact of topological domain formation on the coupling between neighboring genes and the resulting transcription processes.

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Chromosomal Topological Domain Formation Modulates Transcription and the Coupling of Neighboring Genes in Escherichia coli Chromosomal topology and transcription are tightly coupled, yet the quantitative impact of topological constraints on transcription, supercoiling, and the potential coupling between neighboring genes ... https://www.biorxiv.org/content/10.1101/2025.11.23.690031v1