Bernat Olle
@bernatolle.bsky.social
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Founder and CEO at Vedanta Biosciences
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Bernat Olle
CARB-X
about 1 month ago
Countdown to
#GAMRIC2025:
The inaugural Global AMR Innovators Conference kicks off tomorrow in London! Join CARB-X and global leaders as we dive into discussions about
#AMR
policy and antimicrobial research and development.
#GlobalHealth
#CARBX
#IDSky
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Bernat Olle
Art Krieg
about 2 months ago
My new review article covers key points I have not seen in any other review of cancer immunotherapy: i) the difference between IFN-a and IFN-b; ii) the unique role of P1 pDC among all DC subsets; iii) the unique role of TLR7/8/9 among TLRs
nam10.safelinks.protection.outlook.com?url=http%3A%...
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New insights into the role of IFN-α/β and TLR7/8/9 in cancer immunotherapy and systemic autoimmunity
The role of type I interferon (IFN) in mediating tumor immunosurveillance, in situ vaccination, and response to other cancer immunotherapies is well established. The biologic and species-specific diff...
https://nam10.safelinks.protection.outlook.com/?url=http%3A%2F%2Fjitc.bmj.com%2Fcgi%2Fcontent%2Ffull%2Fjitc-2025-012165&data=05%7C02%7CArthur.Krieg%40umassmed.edu%7C11785a937e4641fc595708ddf736a271%7Cee9155fe2da34378a6c44405faf57b2e%7C0%7C0%7C638938536221792165%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C60000%7C%7C%7C&sdata=wydg5LsHvuScGzryxf%2BEH5nhXbqjKso9M%2BXiV%2B3N%2F%2FA%3D&reserved=0
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Bernat Olle
Michael Glickman
4 months ago
Happy to share the most recent preprint from the lab, the thesis work of Dr. Adam Krebs and a collaboration with many, including the Geissmann lab
@mskcancercenter.bsky.social
Here is a short paper thread.
#tuberculosis
#macrophages
đź¦
www.biorxiv.org/content/10.1...
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Human iPSC derived alveolar macrophages reveal macrophage subtype specific functions of itaconate in M. tuberculosis host defense
M. tuberculosis must survive within multiple macrophage populations during infection, including alveolar macrophages (AM) and recruited inflammatory macrophages. In mice, itaconate, produced in macrop...
https://www.biorxiv.org/content/10.1101/2025.07.23.664455v1
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Bernat Olle
Tami Lieberman
4 months ago
We are on the lookout for postdocs for two different projects at the intersection of ecology, evolution, and the human microbiome. See thread for more information and reach out!
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Bernat Olle
Timothy Snyder
7 months ago
There is only one way to end the war: put pressure on the Russians. The Trump people did the opposite: put pressure on Ukraine, and relieved pressure on Russia. They have made the war worse while talking of "peace."
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Bernat Olle
UNITED24
7 months ago
Merci, EmmanuelMacron 💙💛 Every European will be safer if every part of Ukraine is sovereign and pro-European. russian occupation of an independent country creates a precedent that endangers the entire continent.
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Bernat Olle
Sharok Shekarriz
7 months ago
A lot of what looks like microbial engraftment after FMT might actually be noise. Using placebo sequencing and culture-enriched metagenomics, we sort signal from noise. Our latest from the Surette lab:
www.nature.com/articles/s41...
@surettem.bsky.social
@mcmasteruniversity.bsky.social
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Detecting microbial engraftment after FMT using placebo sequencing and culture enriched metagenomics to sort signals from noise - Nature Communications
Here, the authors profile bacterial engraftment in UC patients receiving FMT from a single donor and placebo samples to estimate noise, showing a significant level of false-positive engraftment, which...
https://www.nature.com/articles/s41467-025-58673-x
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Bernat Olle
Daphne Zohar
7 months ago
www.nopatientleftbehind.org/preserving-t...
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Preserving and Modernizing the FDA — No Patient Left Behind
https://www.nopatientleftbehind.org/preserving-the-fda
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Bernat Olle
Physicians for a Healthy Democracy
7 months ago
Sign of the day…Chicago
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Bernat Olle
Jason Norman
7 months ago
looking forward to
#ESCMIDGlobal
next week in Vienna. I'd love to connect and discuss developing microbiome drugs to prevent infection. Come to the Innovation Theater 12 April at 11:30!
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I have a trade deficit with Trader Joe's, who are so unfair because they never buy anything back from me, so I will have to impose some tariffs.
7 months ago
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Bernat Olle
Robert Califf
8 months ago
I can feel the pain in this summary at the end of the day. A lot of people trying to collect themselves. More pain to come. Will need to strengthen our common ties to advance the public health and individual medical outcomes.
yourlocalepidemiologist.substack.com/p/why-we-kee...
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Why we keep going
Today thousands of health workers at the CDC and FDA lost their jobs—effective immediately.
https://yourlocalepidemiologist.substack.com/p/why-we-keep-going?utm_source=substack&publication_id=281219&post_id=160347928&utm_medium=email&utm_content=share&utm_campaign=email-share&triggerShare=true&isFreemail=true&r=7bit1&triedRedirect=true
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Bernat Olle
Pete Buttigieg
8 months ago
From an operational security perspective, this is the highest level of fuckup imaginable. These people cannot keep America safe.
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The Trump Administration Accidentally Texted Me Its War Plans
U.S. national-security leaders included me in a group chat about upcoming military strikes in Yemen. I didn’t think it could be real. Then the bombs started falling.
https://www.theatlantic.com/politics/archive/2025/03/trump-administration-accidentally-texted-me-its-war-plans/682151/
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How Beethoven could come up with this absolute marvel when he was dealing with hearing loss is beyond my comprehension. It's like he found a secret shortcut to reach the soul.
youtu.be/ESilvOS2O9k
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Gustavo Dudamel - Beethoven: Symphony No. 7 - Mvmt 2 (Orquesta SinfĂłnica SimĂłn BolĂvar)
YouTube video by Gustavo Dudamel
https://youtu.be/ESilvOS2O9k
8 months ago
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Bernat Olle
Eric Topol
9 months ago
Our gut microbiome and its metabolites have key interactions with our immune response to cancer and success from cancer immunotherapy. Nice perspective
@jclinical-invest.bsky.social
www.jci.org/articles/vie...
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www.nature.com/articles/s41...
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Metagenomic global survey and in-depth genomic analyses of Ruminococcus gnavus reveal differences across host lifestyle and health status - Nature Communications
Here, the authors present a global meta-analysis of the human gut bacterium Ruminococcus gnavus, established an isolate collection with complete genomes and identified genetic features correlating wit...
https://www.nature.com/articles/s41467-025-56449-x
10 months ago
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www.businesswire.com/news/home/20...
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Vedanta Biosciences Publishes Additional Phase 2 VE303 Results in Nature Medicine
Vedanta Biosciences, a late clinical-stage company developing defined bacterial consortia as oral therapies for gastrointestinal diseases, today annou
https://www.businesswire.com/news/home/20250123611854/en/Vedanta-Biosciences-Publishes-Additional-Phase-2-VE303-Results-in-Nature-Medicine
10 months ago
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I hope the new administration can appreciate that basic research in infectious diseases is also a matter of national security, which we all care about no matter who we vote for
www.propublica.org/article/nih-...
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The Second Trump White House Could Drastically Reshape Infectious Disease Research. Here’s What’s at Stake.
Donald Trump’s pick to lead the federal health agency has vowed to replace hundreds of staffers and shift research away from infectious diseases and vaccines. Such an overhaul could imperil the develo...
https://www.propublica.org/article/nih-niaid-trump-kennedy-bhattacharya-vaccines-research
10 months ago
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Bernat Olle
Jonathan Eisen
10 months ago
Well, I went back to see if the birds came out again yesterday. And it was even more stunning. At first, it seemed like little was going on & then my brother Matt, who came out with/ me to record sound (he's a sound engineer) told us to look up.
#birds
youtu.be/r_1OX3LVK1g
add a skeleton here at some point
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Bernat Olle
Greg Medlock
10 months ago
Assessing Live Microbial Therapeutic Transmission, from Jay Faith
www.tandfonline.com/doi/full/10....
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Assessing live microbial therapeutic transmission
The development of fecal microbiota transplantation and defined live biotherapeutic products for the treatment of human disease has been an empirically driven process yielding a notable success of ...
https://www.tandfonline.com/doi/full/10.1080/19490976.2024.2447836
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Today our team published additional results from the Phase 2 CONSORTIUM study for our lead candidate, VE303, a potential first-in-class Live Biotherapeutic Product which is being evaluated for prevention of recurrent Clostridioides difficile infection (rCDI). full-text access:
rdcu.be/d5ovX
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Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection
Nature Medicine - Results of multi-omic profiling of the microbiome and host immunity of individuals treated with VE303 to prevent recurrent Clostridioides difficile infection in the context of a...
https://rdcu.be/d5ovX
11 months ago
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rdcu.be/d4HCY
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Tracing carriage, acquisition, and transmission of ESBL-producing Escherichia coli over two years in a tertiary care hospital | Genome Medicine
https://rdcu.be/d4HCY
11 months ago
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My parents' work today:
11 months ago
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Bernat Olle
César de la Fuente
11 months ago
(1/5) Traditionally, antibiotic discovery has centered on bacteria and fungi—until now. For the first time, we present a systematic exploration of Archaea—a major yet underexplored branch of the tree of life—as a source of novel antimicrobial compounds.
www.biorxiv.org/content/10.1...
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On the definition of Live Biotherapeutic Product. Online today
@jidjournal.bsky.social
academic.oup.com/jid/advance-...
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Correspondence to “Escape Velocity—The Launch of Microbiome Therapies”
To the Editor—We congratulate Kelly et al on an excellent review of advances in microbiome therapeutic development [1]. The article states that the Food an
https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae575/7905447?login=false
11 months ago
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Bernat Olle
Ran Blekhman
11 months ago
One of my favorite visualizations, showing the sizes of host and microbial cells on the same scale, spanning several orders of magnitude From a review by Baker et al :
pubmed.ncbi.nlm.nih.gov/37700024/
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www.science.org/content/arti...
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War-torn Ukraine has become a breeding ground for lethal drug-resistant bacteria
Urgent action underway to prevent dangerous microbes from spreading beyond country's borders
https://www.science.org/content/article/war-torn-ukraine-has-become-breeding-ground-lethal-drug-resistant-bacteria
12 months ago
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Bernat Olle
Ibra
12 months ago
Denali National Park In Alaska, USA
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This work led by Jay Faith's lab at Mount Sinai maps the number of unique strains of a species that can stably colonize the human intestine for the most common human commensals. A useful guide for design of Live Biotherapeutic Products
www.nature.com/articles/s41...
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Gut microbiota strain richness is species specific and affects engraftment - Nature
Strain richness of gut microbiota ecosystems is a key characteristic underpinning engraftment in faecal microbiota transplantation, and could improve the design of defined live biotherapeuti...
https://www.nature.com/articles/s41586-024-08242-x
12 months ago
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Concerning, coming from someone who understands very well the system
www.cnbc.com/video/2024/1...
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Dr. Scott Gottlieb on RFK: He will cost lives in this country if he follows through on intentions
Dr. Scott Gottlieb, former FDA commissioner and CNBC contributor, joins 'Squawk Box' to discuss the incoming administration's picks for health cabinet positions, where Gottlieb's worries are, and much...
https://www.cnbc.com/video/2024/11/29/dr-scott-gottlieb-on-rfk-he-will-cost-lives-in-this-country-if-he-follows-through-on-intentions.html
12 months ago
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Bernat Olle
Willem van Schaik
about 1 year ago
JOB CLAXON! I am recruiting a post-doctoral researcher on a BBSRC-funded project (36 months) on the genetics and functional genomics of vancomycin resistance in enterococci. Further details here:
edzz.fa.em3.oraclecloud.com/hcmUI/Candid...
Please DM or email me if you want to discuss this post.
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Research Fellow - Department of Microbes, Infections and Microbiomes - 104864 - Grade 7
This exciting BBSRC-funded project aims to mechanistically characterise the fitness costs associated with vancomycin resistance in the Gram-positive opportunistic pathogens Enterococcus faecalis and E...
https://edzz.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_6001/job/5956/?utm_medium=jobshare
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Consider co-signing, if you agree, this letter to the California Congressional Delegation asking them to weigh in U.S. House and Senate leadership to pass the PASTEUR Act by the end of the year.
www.fightinfectiousdisease.org/post/sign-on...
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Sign On Letter - Fungal Infections Deserve Greater Attention from California Legislators
Please review the letter in full below. Sign on form HERE. ***Dear Members of the California Congressional Delegation:California is the epicenter of a public health threat that is stretching our healt...
https://www.fightinfectiousdisease.org/post/sign-on-letter-fungal-infections-deserve-greater-attention-from-california-legislators
12 months ago
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Bernat Olle
Art Krieg
12 months ago
For my inaugural post, I’m sharing this recent talk on the immune considerations in mRNA therapeutics. Optimizing CD8+ T cell responses requires understanding the biology of IFN-a/b, which has been ignored in recent cancer immunotherapy review articles.
youtu.be/Isz5FqRpqbM
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mRNA Therapeutics: immunological issues (from 9th Int. Vaccines R&D Conference, Boston, Nov. 2024)
YouTube video by Art Krieg
https://youtu.be/Isz5FqRpqbM
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Bernat Olle
Jason Norman
12 months ago
Hello world. I'm a researcher at Vedanta Biosciences where we are developing defined bacterial consortia to modulate the microbiome and treat or prevent human disease. General focus areas: microbial ecology, drug discovery, IBD and infectious disease. Wordcloud via
scholargoggler.com
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Bernat Olle
Greg Medlock
12 months ago
For
@asm.org
Microbe June 19-23 2025, I am organizing a special session on manufacturing of Fecal Microbiota Products and Defined Bacterial Consortia. Please consider submitting an abstract and share with others working in this area!
asm.org/Events/ASM-M...
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ASM Microbe | Overview
ASM Microbe 2025 showcases the best microbial sciences in the world and provides a one-of-a-kind forum to explore everything from basic microbiology to translation and application.
https://asm.org/Events/ASM-Microbe/Home
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Has FDA approved any Live Biotherapeutic Products? A: Yes, 2 B: No Are products prepared from human stool LBPs? A: Yes B: No This letter to the editor of @JIDJournal, with Cliff McDonald at CDC and Ryan Ranallo at NIAID seeks clarity on nomenclature
academic.oup.com/jid/advance-...
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Correspondence to “Escape Velocity—the Launch of Microbiome Therapies“
Bernat Olle, Ryan Ranallo, L Clifford McDonald; Correspondence to “Escape Velocity—the Launch of Microbiome Therapies“, The Journal of Infectious Diseases,
https://academic.oup.com/jid/advance-article/doi/10.1093/infdis/jiae575/7905447?login=false
12 months ago
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A proud day today for the Vedanta Biosciences family, as Adam Krebs is just finishing his thesis defense presentation, soon to become our first alum to go on to complete a PhD! Adam did his thesis with
@michaelglickman.bsky.social
at MSKCC working on tuberculosis.
12 months ago
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