Minflux goes to chromatin! Very interesting preprint from @andersshansen.bsky.social lab, featuring co-first author @matteomazzocca.bsky.social, that keeps on making me very proud.

This looks sooo great! Congratulations @mirlab.bsky.social !!

Happy to share Duyen's and Philipp's work on effective binding energy landscape and affinity of RBPJ obtained in vivo by on- and off-rate measurements is now published. Great collaboration with labs of Franz Oswald and Tilman Borggrefe doi.org/10.1038/s414...

Preprint from Marklund and Greenleaf labs on TF binding: www.biorxiv.org/content/10.1... In vitro single molecule imaging + In nuclei single molecule footprinting of KLF on engineeered sequences. On-rates matter more than off-rates, similarly to what previously shown in baceria.

What is the multiscale structure of chromatin condensates? How does it shape thermodynamic and material properties? We address this at near-atomistic resolution🔥🔥🔥 using cryoET (Rosen & Villa labs, led by H Zhou), a new multiscale model (K Russell) and cryoET-guided sims (J Huertas & J Maristany)

This looks very interesting! www.science.org/doi/full/10.... On my reading list!

Real-time visualization of reconstituted transcription reveals RNA polymerase II activation mechanisms at single promoters https://www.biorxiv.org/content/10.1101/2025.01.06.631569v1

Towards community-driven visual proteomics! Excited to finally share this large-scale curated & annotated dataset of 1829 high-quality #cryoET tomograms of the little green alga that just keeps giving— Chlamydomonas! 🧪🧶🧬🌾🌊🌍 Preprint📜: www.biorxiv.org/content/10.1... A short thread🧵👇

Tasty, tasty phase separation. A much needed rigorous study!

Excited to share @domenicnarducci.bsky.social 's paper now out in Mol Cell published back-to-back with the paper from @dewitlab.bsky.social‬ - despite lots of prior work, we find that ZNF143 has no looping function www.sciencedirect.com/science/arti... www.sciencedirect.com/science/arti...

We often speak about chromatin as being accessible or inaccessible, but what does it mean? We wrote a short review on this, 🔬 focused: sciencedirect.com/science/arti... A big thank you to Tom Fillot for his efforts on this and to @hansen_lab @marcelonollmann for their help as editors.