The amazing @shawnfayer.bsky.social has developed a saturation genome editing method in iPSCs enabling MAVEs in differentiated cell types and diploid contexts. Please check it out! And, for some lucky department, Shawn is on the faculty job market!

Welcome back from the break! Next up @juliadiumenge.bsky.social from @alloxbio.bsky.social Mapping allosteric sites at scale to develop better drugs

Next up at #VariantEffect25: Translating computational genomics into clinical clarity we have @shawnfayer.bsky.social from @uwgenome.bsky.social presenting "A cluster-based method for guiding the use of variant effect predictors in clinical variant classification clinical clarity"

Our "Atlas of Variant Effects 2030 Roadmap" is live: zenodo.org/records/1542... 1/n

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📣 We are #Hiring: Program Operation Specialist @brotmanbaty.bsky.social and UW Dept of Genome Science Full-Time | Seattle, WA Apply Now! 🌟 Details ⬇️ tinyurl.com/UWProgramOpe...

The one benefit of the US Senate's average age being approximately 103...they predate routine vaccinations! www.nytimes.com/2024/12/13/u...

Opportunity Alert! Open Call for New Members of the AVE Executive Committee. ℹ️ 📝 www.varianteffect.org/leadership-o... Deadline to submit an application and indicate your interest in joining is December 20th, 2024.

McSweeney’s is spot on, as always.

I made a starter pack of folks affiliated with UW Genome Sciences (past and present) go.bsky.app/L8RAbiJ It's fairly sparse for now, so please let me know if you'd like to be added!

The Atlas of Variant Effects (AVE) Alliance is an international community of researchers, analysts, clinicians, patients and funders working with and alongside major genomics and genetics initiatives and consortia... t.co/GlAMeAKVQI

Biden's asylum ban leads to three more deaths in the desert, where two men, ages 44 and 18, and a 17-year-old girl were found. abc17news.com/news/ap-nati...

I don't think biomedical researchers realize how much is at stake with the upcoming election. Take a look at some snippets from Project2025, the blueprint for the next Trump Administration and then be afraid. Then get organized. Ignoring it and putting our heads in the sand is not an option.