paper alert🚨 Monovalent pseudo-natural products supercharge degradation of IDO1 by its native E3 KLHDC3 - Published by the groups of Herbert Waldmann @waldido.bsky.social , Slava Ziegler and @georgwinter.bsky.social @cemm.oeaw.ac.at in @nature.com Chemistry www.nature.com/articles/s41...

As per January German-English scientist Natalie Scholes (32) will start her own research group at the Netherlands Cancer Institute! ➡️ nki.nl/news-events/news/chemical-matchmaker-in-search-of-societal-impact-natalie-scholes-starts-research-group-at-the-netherlands-cancer-institute/ #NKI #research

Kinase inhibitors can be targeted protein degraders too Chemists think of the 2 modalities as different, but a large screen shows some small molecules can do both. cen.acs.org/biological-c... #chemsky 🧪

Excited to share our work on inhibitors turning degraders now out: doi.org/10.1038/s415...

🧬 Kinase Inhibitors can do more than block their targets! A study by @cemm.oeaw.ac.at[email protected] and #IRBBarcelona reveals that many inhibitors also trigger the degradation of the kinases, uncovering an overlooked mechanism with therapeutic potential. Out in @nature.com ➡️ bit.ly/43SD9xj

🧬Kinase inhibitors that degrade? New study by CeMM, @aithyra.bsky.social & @irbbarcelona.org reveals that kinase inhibitors can also trigger the degradation of their target proteins, becoming a new tool for drug development & #TDP research. ➡️ More: bit.ly/3LY6jor 📄 Paper: bit.ly/43MffU1

New Study published in Nature by the group of @georgwinter.bsky.social, From Inhibition to Destruction - Kinase Drugs Found to Trigger Protein Degradation aithyra.at/news/ #AITHYRA #CeMM #TPD

Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!

🔬A new computational protocol to explore bioactivity spaces and signatures, out now in @natprot.nature.com! Researchers at #IRBBarcelona led by @ptck72.bsky.social present a comprehensive pipeline to integrate new bioactivity data into the #ChemicalChecker Article ➡️ www.nature.com/articles/s41...

📝 🚨 Review alert from the Thomä Lab @alexanderhanzl.bsky.social, Stefan and Clara collected their thoughts on recent molecular glue degrader modalities. Packed with computational predictions, mutations mimicking glues, bivalent engagement and a discussion on mode of action. tinyurl.com/mpmbuuky

Hello, we are AITHYRA! I am very excited to share with you the corporate identity of AITHYRA, the Research Institute for Biomedical AI. Check out the brand design video (sound on!) to learn more. **REMINDER** One week left to apply for Starting PI positions (Life Science and AI/ML). Come join us!

Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost. www.training.nih.gov/research-tra...

🚨 Hiring Alert – Senior Scientist (Biology) 🚨 My lab is looking for a senior scientist to lead functional genomics efforts and decode how small molecules reshape biology 🧬 Lead screens 🤝 Collaborate with top-tier AI/chemistry/biology minds Interested? then apply: cemm.onlyfy.jobs/job/t7lhh1kz