Thanks again for the invite! Had a blast and learned a ton. The future of senescence research is bright.

What are the genetic determinants of immune suppression and immunotherapy resistance in cancer? In a recent study from our lab, Kat Murphy developed innovative genetically engineered mouse models of late-stage prostate cancer to address this question. aacrjournals.org/cancerres/ar...

Could not be more proud of Kat and all she has accomplished in graduate school and beyond! Be sure to also check out her recent paper in Cancer Research elucidating genetic mechanisms of immune suppression and immunotherapy resistance in prostate cancer. aacrjournals.org/cancerres/ar...

How can senescent cells, which are damaged and growth arrested, both block tumor initiation as well as fuel its growth? A recent study published in Cancer Discovery @aacrjournals.bsky.social from Lin Zhou in the lab uncovered some new insights into this puzzle. aacrjournals.org/cancerdiscov...

Now online in Cancer Discovery @aacrjournals.bsky.social: p21-Positive Senescent Stromal Cells Promote Prostate Cancer Immune Suppression & Progression that Can Be Reversed by Senolytic Therapy - by Lin Zhou, @marcus-ruscetti.bsky.social, and colleagues doi.org/10.1158/2159... @umasschan.bsky.social

Congrats to postdoc @nikitab.bsky.social for being awarded an AACR Scholar-in-Training award for this year's #AACRPan25 conference. Be sure to check out her poster # B049 today from 6-9pm!

*NEW paper alert* In a recent study from our former postdoc Shreya Chowdhury and in collaboration with Kate Fitzgerald, we identified PPT1 as a negative regulator of STING in tumor cells whose targeting could reactivate T cell immunity in ovarian and prostate cancers. www.pnas.org/doi/10.1073/...

Super pleased to announce our latest suggesting the cell of origin for #SCLC is most likely the basal cell @nature.com, not the accepted neuroendocrine cell. Implications for the earliest events in cancer, & providing new models of tuft-like cancer. rdcu.be/eGUtj

This month our lab is celebrating 5 years! Couldn't be more thrilled with and proud of the group we have. Great scientists and human beings all around. Also super excited about the science coming out of the lab. Stay tuned for a few new studies dropping in the upcoming weeks.

Congrats @nikitab.bsky.social !

Why do we even have to do this? I wondered the whole time at Stand for Science. 🧪 But it was inspiring to see so many people committed to fighting for truth, science, and justice!

#standupforscience Boston

Congrats to Haruka from the Atukorale and Ruscetti labs for passing her qualifying exam to become a Ph.D. candidate yesterday! We are proud mentors and can't wait to see what you can accomplish through engineering LNPs for drug delivery in pancreatic cancer!

Happy to highlight work from Zhao et al., who developed 4! new mouse models to trace and genetically manipulate different p16+ senescent cell types that will be invaluable to the field. Check out my spotlight @Dev_Cell and original article in @cellcellpress.bsky.social www.cell.com/developmenta...

Happy to share our recent review on cellular senescence and its impact on tumor immune surveillance authored by Lin Zhou and Boyang Ma in the lab, out now online at Trends in Cancer. Lots of exciting developments in the field over the past few years worth checking out! www.cell.com/trends/cance...

Always wonderful to see how our lab family grows each year. Happy Holidays from the Ruscetti and @pitarresilab.bsky.social groups!

🧪1/ 🚨New paper on ecDNAs from our lab! We reveal a strategy to engineer extrachromosomal DNA (ecDNA) amplifications in cells & mice. Let's dive in! Let’s dive in! 🧵👇 www.nature.com/articles/s41...

First post on @bsky.app! Excited to engage with the scientific community, share our lab's research on tumor immunology and cellular senescence, and highlight the work and accomplishments of our inspiring lab members on this platform.

I'm thrilled to share our latest research, published in Nature Communications. This work highlights how pancreatic cancer cells hijack cell polarity proteins to regulate macropinocytosis and tumor metabolism, shedding light on potential therapeutic vulnerabilities. www.nature.com/articles/s41...

No better 1st post on this platform than this - the Pitarresi and Ruscetti labs at UMass Chan raising awareness on World Pancreas Cancer Day. Surely a long way to go but fueled by a singular purpose of defeating this deadly malignancy!