Erin E. Carlson
@eecchemistry.bsky.social
📤 46
📥 90
📝 4
science lover, feminist, mentor, and nature enthusiast, she/her
http://carlson.chem.umn.edu
An incredible honor - my group past and present deserved immense thanks.
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10 months ago
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Erin E. Carlson
C&EN (Chemical & Engineering News)
10 months ago
At
#ACSSpring2025
, Jennifer Prescher, an associate professor of chemistry at the University of California, Irvine, described how her team is developing bioluminescent RNA tags to help visualize RNA.
cen.acs.org/acs-news/acs...
#chemsky🧪
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A bioluminescent probe to track RNA
New ‘RNA lantern’ lets scientists peer into cellular dynamics in real time
https://cen.acs.org/acs-news/acs-meeting-news/bioluminescent-probe-track-RNA/103/web/2025/03?sc=250329_sc_eng_blue_cen
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We have so many awesome new research groups at UMN Chem - check out this beautiful work!
@ochemgrenning.bsky.social
@umnchemistry.bsky.social
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10 months ago
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Erin E. Carlson
Trader Lab
10 months ago
Really proud to have this out in J Med Chem! Congrats to Christine and
@codyloy.bsky.social
pubs.acs.org/doi/10.1021/...
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Immunoproteasome as a Target for Prodrugs
Immunoproteasome (iCP) is a proteasome isoform that is expressed under inflammatory conditions such as cytokine interferon-γ exposure. The iCP has different catalytic subunits other than the standard CP (standard core particle), allowing the production of major histocompatibility complex class I (MHC-I) compatible peptides for eventual T-cell activation. We have previously reported the design of a fluorescent probe that monitors iCP activity in cells called TBZ-1, and we applied TBZ-1’s iCP recognition sequence for prodrug release into iCP-active cells. Here, we demonstrate a proof-of-concept of the iCP as a prodrug release enzyme. The “payload” we utilized was a toxic moiety, doxorubicin, and a degrader for transcription factor, BRD4. Both examples show that iCP activity is required to elicit cell death or degradation of BRD4. This report highlights that the iCP is a viable prodrug target, and its activity can be used to release a variety of cargo in cells expressing the iCP.
https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c03017
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Erin E. Carlson
ACS BIOL: Division of Biochemistry and Chemical Biology
10 months ago
The 2025 ACS Chemical Biology Young Investigator Award goes to Professor Jeremy Baskin! Congrats to Jeremy & our other esteemed presenters for yesterday's great symposium! Jennifer Prescher,
@jeremybaskin.bsky.social
, Carsten Schultz,
@chembiobryan.bsky.social
,
@sonjakrane.bsky.social
,
@pubs.acs.org
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A bit belated congratulations, but still so worth celebrating!
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10 months ago
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So thrilled to have amazing mass spec happening in our department!
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10 months ago
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Erin E. Carlson
Laura Kiessling
10 months ago
A new means of selectively imaging the inner mycolate of mycobacteria using a compound that covalently modifies an enzyme intercepts to create a new intermediate with the Kim lab,
@thebrysonlab.bsky.social
and the Bernhardt lab.
#TB
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