Andrew Gulick
@amgulick-lab.bsky.social
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Structural Biology Lab – focused on remarkable enzymes of natural product biosynthesis
reposted by
Andrew Gulick
I-75 Scientist
6 days ago
Excellent news. The NIGMS Building Undergraduate Research Training (BURT) T34 NOFO is published. First due is Feb 25th, for December 26 funding. This condenses previous UG NOFOs so reach out to email/previous PO if you have Qs.
files.simpler.grants.gov/opportunitie...
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PAR-26-033: NIGMS Institutional Biomedical Undergraduate Research Training (BURT) Program (T34)
https://files.simpler.grants.gov/opportunities/d88aea72-290a-4396-83ba-139886a6ffc8/attachments/e59a911d-8bc5-483a-a7e0-0d1ac27bff83/PAR-26-033-Full-Announcement.html
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Andrew Gulick
Needhi Bhalla 💅🏽
16 days ago
Hey all, I reached out to the PO of my NIGMS MIRA to ask if the gov't shut down, and rescheduling of study sections, might allow for some accommodation to the standard rule that PIs cannot resubmit a MIRA while their MIRA (or other RPG) is under review (waiting in scores or summary statements) 🧪
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16 days ago
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There is still time to register and submit an abstract to the 29th Enzyme Mechanisms Conference. The venue has extended the deadline for room reservations at negotiated rate. It is shaping up to be a great event.
www.enzymemechanismsconference.org
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EMC2026 29th Enzyme Mechanisms Conference
Since their inception in 1969, Enzyme Mechanisms Conferences have brought together academic and industrial scientists to discuss new ideas at the forefront of mechanistic enzymology. EMC2024 will take...
https://www.enzymemechanismsconference.org/
23 days ago
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Andrew Gulick
Tom Hollenstein
27 days ago
So...my undergrad thesis student is doing a quality analysis of studies found in meta-analyses. She identified a few and we contacted the authors to request their effect sizes and other variables for the studies in their papers. Here's what happened:
scientiapsychiatrica.com/index.php/Sc...
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The Impact of Social Media on Adolescent Mental Health: A Meta-Analysis | Scientia Psychiatrica
Introduction: The proliferation of social media has raised significant concerns about its potential effects on the mental health of adolescents. This meta-analysis aims to provide a comprehensive asse...
https://scientiapsychiatrica.com/index.php/SciPsy/article/view/175
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Andrew Gulick
Elizabeth Kolbert
about 1 month ago
Excited to be going on
@thedailyshow.com
tonight to discuss climate change, my new book, and the general state of the planet.
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Andrew Gulick
Jeremy Berg
about 1 month ago
So, let me share the NIGMS processes from my time. 1/8
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One week deadline to abstract submission for the
#Enzyme
mechanisms Conference. Dec 1, 2025
www.enzymemechanismsconference.org/abstract-sub...
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Abstracts | emc2026
https://www.enzymemechanismsconference.org/abstract-submission
about 1 month ago
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Happy 100th, structural biology
pubs.aip.org/aca/sdy/arti...
Delightful perspective by George Phillips and Ed Lattman. Have a piece of cake everyone.
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Happy 100th, structural biology
About 100 years ago, the field of structural biology was born, led by James B. Sumner who recognized that enzymes were molecules with specific functions. In its
https://pubs.aip.org/aca/sdy/article-lookup/doi/10.1063/4.0000788
about 1 month ago
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Andrew Gulick
Royal Society of Chemistry
about 2 months ago
Oral abstract submission is now open for Directing Biosynthesis VIII, an event that has been connecting
#Biosynthesis
researchers for over a decade. Network and discuss the latest research, get all the details and submit: rsc.li/dbviii
#DBVIII
#ChemSky
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Andrew Gulick
Drug Monkey
about 2 months ago
Notes on NIH matters as the government opens up again
drugmonkey.wordpress.com/2025/11/14/n...
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Notes on NIH matters as the government opens up again
A tweet from someone apparently positioned to know claimed the damage totals from the government shutdown amounted to 379 study sections postponed, within which 24,380 NIH grant applications were s…
https://drugmonkey.wordpress.com/2025/11/14/notes-on-nih-matters-as-the-government-opens-up-again/
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Andrew Gulick
Klebsiella Papers
about 2 months ago
Protein Engineering of Biosynthetic Enzymes Unlocks Libraries of Bioactive Tilimycin Analogs
https://doi.org/10.1021/acscatal.5c05921
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Andrew Gulick
Janice Tullock
about 2 months ago
No no no begs every archivist. You are never going to be able to find anything. Please don’t start using emojis in file names. Who asked for this? What fresh hell is next?
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As email filters make it hard to let people know about upcoming deadlines, I want to remind everyone here that the Enzyme Mechanisms Conference is fast approaching. The program is up on the website and the list of posters (not yet posted) looks amazing.
www.enzymemechanismsconference.org
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EMC2026 29th Enzyme Mechanisms Conference
Since their inception in 1969, Enzyme Mechanisms Conferences have brought together academic and industrial scientists to discuss new ideas at the forefront of mechanistic enzymology. EMC2024 will take...
https://www.enzymemechanismsconference.org/
about 2 months ago
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Andrew Gulick
getacrystal
about 2 months ago
The National Crystallization Center is hiring for two positions: a research scientist position focused on progressing our crystallization optimization projects, and a research support specialist to support operations of the Crystallization Center!
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Andrew Gulick
Jeremy Berg
about 2 months ago
A New Thread on NIH Forward Funding I recently posted an analysis of forward funding of NIH grants from 2015-25. This analysis was flawed and should be ignored. I apologize for the misleading information I present an analysis of my error and a revised analysis which I am confident is right. 1/25
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Andrew Gulick
Science Magazine
2 months ago
"For me, success in retirement has involved mapping out a realistic plan that is both enjoyable and academically fulfilling."
#ScienceWorkingLife
https://scim.ag/47iicOq
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Last post about Flash Talk Deadline for the Enzyme Mechanisms Conference! Deadline is tomorrow (Saturday 11/1). See guidance on the website.
www.enzymemechanismsconference.org/junior-inves...
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Junior Investigators | emc2026
https://www.enzymemechanismsconference.org/junior-investigators
2 months ago
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Andrew Gulick
Masschelein Lab
2 months ago
Polyunsaturated fatty acid (PUFA) synthase enzymes turn out to be far more versatile than we ever imagined! In our new preprint, we reveal a largely untapped biosynthetic space where they team up with PKSs and NRPSs to create new types of bioactive amphiphilic metabolites. 👉http://bit.ly/4hzUUak
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Charting the biosynthetic landscape of hybrid polyketide-nonribosomal peptide-specialized lipids
Polyunsaturated fatty acid (PUFA) synthase-like enzymes are best known for their role in membrane lipid biosynthesis in marine bacteria, but have also been repurposed for the assembly of specialized l...
http://bit.ly/4hzUUak
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reposted by
Andrew Gulick
AZ Faust
2 months ago
I have seen too many junior-to-mid career people making this mistake so I need to get this message out there: Once you get your first big award (R01, CAREER, standard NSF, BL2 DoD), your most important task is to publish papers that cite that grant for support.
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#EnzymologySky
: There are still a few slots left. The deadline for the trainee opportunities at EMC2026 has been extended to November 1.
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2 months ago
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reposted by
Andrew Gulick
3 months ago
📢 New preprint: Experiment-guided AlphaFold3 resolves accurate protein ensembles.
doi.org/10.1101/2025...
AlphaFold3 is incredible, but has crucial limitations: it typically collapses to a single conformation, ignoring the inherent dynamics of proteins. And it can be wrong. Here's a solution. 🧵👇
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Andrew Gulick
Jeremy Berg
3 months ago
I actually had heard the the potential NIEHS appointment 2 days ago and broke the news about it at the STAT Summit. I did not share any details since I did not have confirmation. Eric Green shared his views about the importance of process and applicant quality. 1/5
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Morning re-post...
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3 months ago
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Ever true.
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3 months ago
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Deadline is coming up for Trainee opportunities to present your poster via a Flash Talk at the Enzyme Mechanisms Conference (and compete for the Founders Award!)
www.enzymemechanismsconference.org/junior-inves...
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Junior Investigators | emc2026
https://www.enzymemechanismsconference.org/junior-investigators
3 months ago
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Happy to report our latest. Here, Monica used structure-guided mutants of the tilimycin/tilivalline NRPS to produce analogs from alternate building blocks. Several analogs of the pyrrolobenzodiazepine tilimycin were isolated and may show higher activity.
pubs.acs.org/doi/10.1021/...
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Protein Engineering of Biosynthetic Enzymes Unlocks Libraries of Bioactive Tilimycin Analogs
Natural products continue to inspire therapeutic innovation due to their structural complexity and biological potency. Pyrrolobenzodiazepines (PBDs), known for antitumor activity, function by covalently binding to guanine bases in DNA, a mechanism that is inherently species-agnostic. However, their potential as antibiotics remains underexplored as modest antibiotic activity is commonly seen with this class of compounds. Here, we produce analogs of tilimycin and tilivalline, two PBDs produced by the gut microbe Klebsiella oxytoca. We mutated NpsA, the nonribosomal peptide synthetase (NRPS) pathway protein responsible for initiating biosynthesis through adenylation of 3-hydroxyanthranilic acid on the pathway to form tilimycin and tilivalline, to enhance promiscuity with substrate analogs. Using structure and informatics-guided mutagenesis, we developed a rapid screening method to identify compatible enzyme-building block combinations to generate a panel of tilimycin and tilivalline analogs. We identified compounds that possess the ability to inhibit DNA polymerase and that show growth inhibitor activity with a DNA-repair mutant of E. coli. This work demonstrates the feasibility of NRPS reprogramming to use biocatalytic approaches to access non-natural derivatives with antibiotic potential and highlights tilimycin analogs as candidates for Gram-negative antibacterial development.
https://pubs.acs.org/doi/10.1021/acscatal.5c05921
3 months ago
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Andrew Gulick
Mark Peifer (He, him)
3 months ago
I'm very excited to announce that UNC Biology has 6 faculty positions open this year! The first is for an Asst Professor who studies organismal resilience using an integrative approach 1/n
unc.peopleadmin.com/postings/307...
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Andrew Gulick
🐸SayItToMyFace🚫👑
3 months ago
Love this! So talented and creative. It’s the soundtrack to the scientific apocalypse we are living in! I follow
@ellecordova.bsky.social
here but this wasn’t posted. This was from TikTok! Enjoy!
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reposted by
Andrew Gulick
3 months ago
A rapid combinatorial assembly method for gene cluster characterisation illuminates glidobactin biosynthesis
https://pubmed.ncbi.nlm.nih.gov/41050206/
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correction: "directing PIs to put all their eggs in one basket."
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3 months ago
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I too strongly endorse this essay.
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3 months ago
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Whoa.
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3 months ago
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reposted by
Andrew Gulick
dr℮w
3 months ago
It seems the GRFP solicitation is FINALLY released (like 5 minutes ago)! Due dates have also been pushed back, thankfully! 🧪 🔭
www.nsf.gov/funding/oppo...
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NSF Graduate Research Fellowship Program (GRFP)
https://www.nsf.gov/funding/opportunities/grfp-nsf-graduate-research-fellowship-program/nsf25-547/solicitation
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Andrew Gulick
Dr Katherine Duncan
3 months ago
There seems to quite a few new faces lately, so if I haven’t already added you, but you’d like added please let me know and for anyone interested in following more microbial natural products folks, then our starter pack is now 100 strong
go.bsky.app/72NeGsT
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Andrew Gulick
Challis-Alkhalaf Group
4 months ago
Lona Alkhalaf will speak about the discovery, structure, and mechanism of a cool new family of enzymes discovered by the group at the 29th Enzyme Mechanisms Conference.
www.enzymemechanismsconference.org/speakers
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Speakers | emc2026
https://www.enzymemechanismsconference.org/speakers
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Andrew Gulick
Stephanie Wankowicz
4 months ago
Structural bioinformatics is incredibly powerful on its own or when paired with theory or experiment. One of the PDB's superpowers isn’t from one structure, but comparing many to uncover folds, binding sites, and subtle conformational shifts.
chemrxiv.org/engage/chemr...
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10 Rules for a Structural Bioinformatic Analysis
The Protein Data Bank (PDB) is one of the richest open‑source repositories in biology, housing over 277,000 macromolecular structural models alongside much of the experimental data that underpins thes...
https://chemrxiv.org/engage/chemrxiv/article-details/68bf31c823be8e43d6c8660e
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When I've had a few spare minutes for the past few weeks, I've spent it browsing the literature and writing emails to authors of enzymology papers who are not part of the EMC mailing list.
www.enzymemechanismsconference.org
Too many people who otherwise should don't know about this gem.
4 months ago
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You'll laugh but... This is how I feel watching a Mets game when they have a big lead in the late innings and the TV pans across the diversity of fans at Citi Field:
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4 months ago
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reposted by
Andrew Gulick
Maya Kaufman
4 months ago
BREAKING, from NY Playbook PM: New York Gov. Kathy Hochul will sign an executive order allowing pharmacists to prescribe and administer Covid vaccines to New Yorkers who request them.
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The Trainees page at the Enzyme Mechanisms Conference website is updated. Students and Postdocs can submit a 3 minute flash talk "audition" for one of 10 slots to be presented before the poster sessions.
www.enzymemechanismsconference.org/junior-inves...
(1/2)
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Junior Investigators | emc2026
https://www.enzymemechanismsconference.org/junior-investigators
4 months ago
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Andrew Gulick
Jeremy Berg
4 months ago
Yes, it was carefully hidden in the New England Journal of Medicine. Pfizer/BioNTech vaccine (
www.nejm.org/doi/pdf/10.1...
) 1/2
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Andrew Gulick
Dr. David Miller 🏳️🌈
4 months ago
🧪 And House appropriators say: no cuts to NIH budget! House subcommittee version just came out (link below). Holds NIH flat at $48 billion. To be clear: this is far from over. But a good sign that science still matters across both sides of aisle. YOUR VOICE MATTERS!!
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Andrew Gulick
James Taylor
4 months ago
Turns out it doesn't even matter if the sound goes out for an entire minute in the middle of a concert if you have the right audience. Great job, everyone at MGM Music Hall at Fenway! And thanks to
#LuisConte
for the percussion-eye view.
youtu.be/NHcAFVxvuEE
#JT
#JamesTaylor
#2025Tour
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Sound Loss at MGM Music Hall - James Taylor
YouTube video by James Taylor
https://youtu.be/NHcAFVxvuEE
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Andrew Gulick
University at Buffalo
4 months ago
The Interlocking UB, loading in 3...2...1 ⏩ Welcome to the herd, Bulls! We're so glad to have you at
#UBuffalo
💙
#UBTrueBlue
🤘🏾
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Andrew Gulick
Kelly Sheppard (he/him/his)
5 months ago
Skidmore is hiring a TT position in Biology specializing in bioinformatics. 09/01 deadline for submitting an application.
eodq.fa.us6.oraclecloud.com/hcmUI/Candid...
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Assistant Professor, Biology
Assistant Professor in Biology specializing in Bioinformatics, including functional genomics, meta genomics, transcriptomics, proteomics and/or metabolomics. Start in Fall 2026.
https://eodq.fa.us6.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX/job/2743/?utm_medium=jobshare&utm_source=External+Job+Share
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Andrew Gulick
ChimeraX
5 months ago
Here's how to predict binding of tens or hundreds of small molecules to protein assemblies using Boltz 2 in ChimeraX. Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures.
www.rbvi.ucsf.edu/chimerax/dat...
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Andrew Gulick
University at Buffalo
5 months ago
#AI
for social good 🫱🏼🫲🏽 During his visit to
#UBuffalo
, SUNY chancellor John B. King saw demos from faculty and students showcasing how Empire AI is driving solutions that can improve lives across the globe. Learn more 🔽
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King marvels at speed of Empire AI
SUNY Chancellor John B. King Jr. received an update on UB's Empire AI-supported work during a visit to campus.
https://www.buffalo.edu/ubnow/stories/2025/08/chancellor-visit-empire-ai.html
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Andrew Gulick
Derek Lowe
5 months ago
No matter how hard you try, you simply cannot guess the journal withe the highest “impact factor” in organic chemistry last year. Really. Nor will you guess many of the other “winners”:
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Journal Impact Nonsense
https://www.science.org/content/blog-post/journal-impact-nonsense
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Damn,
@theatlantic.com
has been knocking it out of the park of late. Today, this is a good one to read. (gift article)
www.theatlantic.com/magazine/arc...
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The Making of Kurt Vonnegut’s ‘Cat’s Cradle’
How the novelist turned the violence and randomness of war into a cosmic joke
https://www.theatlantic.com/magazine/archive/2025/08/kurt-vonnegut-cats-cradle-hiroshima/683255/?gift=pQQV6Hkf4Xdy7i13EluIK1Y7slCDSfI8xI8jexD4PHw&utm_source=copy-link&utm_medium=social&utm_campaign=share
5 months ago
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