It seems the GRFP solicitation is FINALLY released (like 5 minutes ago)! Due dates have also been pushed back, thankfully! 🧪 🔭 www.nsf.gov/funding/oppo...

There seems to quite a few new faces lately, so if I haven’t already added you, but you’d like added please let me know and for anyone interested in following more microbial natural products folks, then our starter pack is now 100 strong go.bsky.app/72NeGsT

Lona Alkhalaf will speak about the discovery, structure, and mechanism of a cool new family of enzymes discovered by the group at the 29th Enzyme Mechanisms Conference. www.enzymemechanismsconference.org/speakers

Structural bioinformatics is incredibly powerful on its own or when paired with theory or experiment. One of the PDB's superpowers isn’t from one structure, but comparing many to uncover folds, binding sites, and subtle conformational shifts. chemrxiv.org/engage/chemr...

When I've had a few spare minutes for the past few weeks, I've spent it browsing the literature and writing emails to authors of enzymology papers who are not part of the EMC mailing list. www.enzymemechanismsconference.org Too many people who otherwise should don't know about this gem.

You'll laugh but... This is how I feel watching a Mets game when they have a big lead in the late innings and the TV pans across the diversity of fans at Citi Field:

BREAKING, from NY Playbook PM: New York Gov. Kathy Hochul will sign an executive order allowing pharmacists to prescribe and administer Covid vaccines to New Yorkers who request them.

The Trainees page at the Enzyme Mechanisms Conference website is updated. Students and Postdocs can submit a 3 minute flash talk "audition" for one of 10 slots to be presented before the poster sessions. www.enzymemechanismsconference.org/junior-inves... (1/2)

Yes, it was carefully hidden in the New England Journal of Medicine. Pfizer/BioNTech vaccine (www.nejm.org/doi/pdf/10.1... ) 1/2

🧪 And House appropriators say: no cuts to NIH budget! House subcommittee version just came out (link below). Holds NIH flat at $48 billion. To be clear: this is far from over. But a good sign that science still matters across both sides of aisle. YOUR VOICE MATTERS!!

Turns out it doesn't even matter if the sound goes out for an entire minute in the middle of a concert if you have the right audience. Great job, everyone at MGM Music Hall at Fenway! And thanks to #LuisConte for the percussion-eye view. youtu.be/NHcAFVxvuEE #JT #JamesTaylor #2025Tour

The Interlocking UB, loading in 3...2...1 ⏩ Welcome to the herd, Bulls! We're so glad to have you at #UBuffalo 💙 #UBTrueBlue 🤘🏾

Skidmore is hiring a TT position in Biology specializing in bioinformatics. 09/01 deadline for submitting an application. eodq.fa.us6.oraclecloud.com/hcmUI/Candid...

Here's how to predict binding of tens or hundreds of small molecules to protein assemblies using Boltz 2 in ChimeraX. Accuracy depends on how similar the ligands and binding pockets are to existing experimental structures. www.rbvi.ucsf.edu/chimerax/dat...

#AI for social good 🫱🏼‍🫲🏽 During his visit to #UBuffalo, SUNY chancellor John B. King saw demos from faculty and students showcasing how Empire AI is driving solutions that can improve lives across the globe. Learn more 🔽

No matter how hard you try, you simply cannot guess the journal withe the highest “impact factor” in organic chemistry last year. Really. Nor will you guess many of the other “winners”:

Damn, @theatlantic.com has been knocking it out of the park of late. Today, this is a good one to read. (gift article) www.theatlantic.com/magazine/arc...

BIOCHEMISTS! We are looking for a new post-doctoral colleague at BU who will be devoted to a combination of teaching Biochemistry and engaging in Research. Ask me anything! The deadline is short, but the job is awesome. #ChemJobs You can apply here: academicjobsonline.org/ajo/BU/CH/PA...

Another worthwhile read.

Whoa.

The NIH budget will INCREASE by $400 million — not slashed by 40%, as Trump proposed — according to a proposal by Senate appropriators, says Sen Murray. "Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.

UB Followers!

First copies of my book are here!! As a new faculty member, I realized that in addition to my research job, I also had a leadership job…and I wasn’t prepared for that. This book is the guide I wish I’d had then, with the goal of helping others now.   jenheemstra.com/book

Whoa.

Please register early and upload your abstracts. Looking forward to seeing many of you in Milwaukee in September!

I'm really proud of this work by Jae Kennemur and Yueming Long. #Enzymes rock, with some help from #directed evolution to do chemistry not known in nature (and really hard for humans, too). @caltechcce.bsky.social pubs.acs.org/doi/10.1021/...

No matter where you look, #UBuffalo shines through. 💙📸

NIH will only accept six applications per PI per calendar year. drugmonkey.wordpress.com/2025/07/17/n...

Come read about our thoughts on why cyanobacteria are underrepresented in drug discovery and how both synthetic biology and native hosts can help. This was fun to work on with a great group of people who include @dtdoering.bsky.social @danudwary.secondarymetabolism.com @eustaquiolab.bsky.social

You don‘t have to review or read all of them… but where-ever possible you should select a society publisher! www.theguardian.com/science/2025...

Agreed. I haven't made it all the way through this article but it contains some interesting and inspiring statistics

This is exactly what the internet is for.

Seed to sub-Å! We just solved crambin at 0.85Å with #MicroED straight from spontaneous nanocrystals, phased ab-initio from a 5-res helix. Video shows diffraction ➜ ugly start map ➜ beautiful spheres. Preprint: www.biorxiv.org/content/10.1... #StructuralBiology #CryoEM

A short Bluetorial about my early days as the Director of the National Institute of General Medical Sciences (NIGMS) at NIH. The importance of feeling responsibility and taking pride in doing the best job you can

Harness the powerful capabilities of RCSB PDB Search and Data API services through the new all-in-one Python toolkit, rcsb-api. pdb101.rcsb.org/news...

@jeremymberg.bsky.social to share to others - this is a forecasted NIGMS MIRA funding opportunity for established/new investigators as I know people have been asking (FOR-GM-27-002) - due date appears to be late Jan 2026: grants.gov/search-resul...

Fro the last few years, as part of a final assignment in my senior biophysical chem class I ask students to share a class-related memes, with ones they make themselves highly encouraged! For everyone's enjoyment, here are some of my favorites! #chemistry #biochemistry #sigfigs #units 🧪

Over half* of all grants, papers, and talks on natural products cite Newman and Cragg's reports that over half of all FDA-approved drugs are inspired by natural products. This Perspective from Moore and Newman may ultimately be cited even more. pubs.acs.org/doi/10.1021/... (*estimate)

Beloit, WI revitalized its waterfront and chose this way to celebrate it: by bringing to life Georges Seurat's "A Sunday Afternoon on the Island of La Grande Jatte."

i almost can’t read this it makes me so angry. delusional grifters with purity fetishes and eugenic worldviews have brought pain, suffering and death to children www.nytimes.com/2025/06/22/u...

A clever approach for identifying natural product BGCs on the basis of their regulatory networks by van Wezel and colleagues.

STAT story about the ruling www.statnews.com/2025/06/16/n... 1/n

Good morning, dorks!...Today's your chance to stand up with us and 23,380 other proud science stans by signing your name to our Open Letter in Support of the 300+ NIH heroes of the historic #BethesdaDeclaration. Be historic with us! zurl.co/Jdx4s#BethesdaDeclaration #StandUpForScience #NIHLoveLetter #GetInDorks

Extensive Propublica story about grant terminations Sharing specifics and putting faces on the research… Definitely worth a read projects.propublica.org/nih-cuts-res...

Professor Robertson makes some good points here about a career in science.

DYK the JGI has two podcasts? Genome Insider highlights the stories of our users whose research has been enabled by JGI support: jointgeno.me/GenomeInsider The Natural Prodcast, hosted by @danudwary.secondarymetabolism.com, is for all of you #secmet folks: jointgeno.me/NaturalProdcast 🖥️🧬🌱🦠🧪🍄

I urge others to similarly support our patriots at NIH who use their training and talents to improve human health and position the US as the world’s leader in biomedical discovery, innovation and technology development 🙏

Interestingly, I've largely abandoned X. However, I posted our recent siderophore article on both sites as I had a larger footprint in the #ChemBio, #siderophore, and #naturalproduct communities that I haven't quite reconstructed here. So, if you're into interested, go look for our latest.

(Longish thread. Apologies) I have met many inspiring colleagues over the past few months, many of whom are in academic institutions targeted by the current administration, and many others who are about to be (the analogy to the ‘eye of Sauron’ has been invoked many times; gallows humor). 1/

I'm really excited to share this new paper by Mercedes that describes the biosynthetic gene cluster for an unusual siderophore. Identification and Characterization of the Biosynthesis of the Hybrid NRPS-NIS Siderophore Nocardichelin | ACS Chemical Biology pubs.acs.org/doi/10.1021/...