Pleased to share my latest review article with @tandfresearch.bsky.social, taking a deep dive into neuronal autophagy, how Huntingtin coordinates it, and how the process goes awry in Huntington’s disease. doi.org/10.1080/27694127.2025.2472450 #Neuroscience #Autophagy #HuntingtonsDisease

Always exciting when a dissertation chapter makes it to publication. Thrilled to share this work in Cell Death & Disease, exploring putative roles of GSK3β and ERK1 phosphorylation in Huntington’s disease. Full article: doi.org/10.1038/s414... Huge thanks to all co-authors & contributors! 🦾

Do you want to hear the latest and greatest about the neuronal cytoskeleton? Join us in Chile next April for #NeuroCyto2025, organized by @monicamsousa.bsky.social, Kassandra Ori-McKenney and Tomás Falzone! Registration is open until March 5: neurocytoskeleton.com/2025/

Exciting work! 🎉

Likely my final #FluorescenceFriday post of 2024! 🔬 Here’s a kinetic showcasing pkMito dynamics and the heterogeneity of axonal mitochondria I'm looking forward to all of the incredible microscopy from this community in 2025. Happy Holidays everyone! ☃️❄️

Some #MicroscopyMonday to kick off the week! 🔬⛄ I paired #lysosome and #mitochondria kinetics side-by-side to highlight their distinct axonal motility. I thought this nicely shows the need for organelle-specific metrics when designing high-throughput screening assays. #Neuroscience #CellBiology

The cell biology team at ALS Therapy Development Institute will be sharing some exciting work today at the 2024 International Symposium on ALS/MND. #endALS #Neuroscience #CellBiology If you're here in Montreal, come chat with us during theme05: human cell biology and pathology (details below): 🧵

Important article that challenges the classic view of axons as simple tubes. To what extent they fluctuate in diameter is up for debate - see some thoughts in this commentary piece in @science.org. Exciting time for axon scientists!

Axonal mRNA studies always catch my attention. Great preprint from the Redemann and Hermann labs: www.biorxiv.org/content/10.1... ". . . only very few studies have paid attention to the important roles of distinct mRNA expression profiles of the axon and soma . . ." #MoreAxonSeq #Neuroscience

Sharing #FluorescenceFriday early before the food coma hits this weekend! 🦃 Here are longitudinal kinetics showing dose-dependent degeneration from an exogenous stressor: part of an assay developed for drug screening with iPSC-derived neurons. 🔬 #Microscopy #Neuroscience #Bioimaging #CellBiology

I just created a Microscopy feed that tracks anything that has a cute 🔬 emoji on it as well as the simple #microscopy and #imaging tags. Enjoy! bsky.app/profile/did:...

Fall hikes 😌

Interested in microscopy and/or image analysis? Check out my newest starter pack of super folks.(which also links to the previous, 150-awesome-full one! Both also link to other imaging-y starter packs as I find them) go.bsky.app/MU8c2A2

ICYMI: The October FocalPlane features… webinar included talks from @helenajambor.bsky.social (‘How not to lie with image data’) and Kota Miura ('Reproducible bioimage analysis for ensuring #scientificintegrity'). Watch the recording at bit.ly/4fyB2SU #PublicationIntegrityWeek #COPE

My turn to create a starter pack for scientists using live imaging in their research! Of course, I’ve likely missed many—please let me know who else I should include. Thanks! go.bsky.app/KYYr7xc #liveimaging #livevellimaging #microscopy

Some highlights from optimizing AAV transduction efficiency of an FL-reporter in iPSC-derived motor neurons. Excited about striking a balance between sparse-labeling and 'painted' coverage. #Neuroscience #Microscopy #CellBiology #AAV #iPSC

Made a starter pack for microscopy and image analysis - please (self-)nominate additions! go.bsky.app/Nwa91pC

I feel the science-to-nonsense ratio is much better on this site: Enjoy these jittery mitochondria sifting through axons of patient-derived motor neurons thanks to the pkMito probe from @spirochrome.com #neuroscience #science #microscopy #bioimaging #mitochondria

I am excited to announce that the Journal of Cell Science will have a special issue on imaging cell architecture and dynamics, guest-edited by myself and Lucy Collinson. Consider this issue to publish your work. Find out more: journals.biologists.com/jcs/pages/im...

Fall is Elite 🍂😎 #EchoLake #MtCannon

Always a good feeling to find a positive hit in my axonal regeneration assay🔬 #neuroskyence

Once in a while, glia (cyan) migrate out of organoids and completely steal the show from neurons (green) and their axons (magenta) 🔬

Please send invites to everyone replying to this thread: twitter.com/iskander/sta... 🧪🧬🖥️⚕️

So... when will support for GIFs arrive? 😬

Only a few days before getting back to the lab grind, so we took a boat to the Westman Islands and hiked up the Eldfell volcano... I have no complaints about these views! 🌋😌🇮🇸

The Icelandic tundra is simply breathtaking 🏔️

The highlight of this photo is not the Strokkur geyser blasting off, no, it is the fact that we found a bit of sunshine 🇮🇸🌞

Stepped away from the microscope to explore Iceland. So far, I found just about all of the peace and beauty you could ask for 😌 🇮🇸

These liquid nitrogen-infused cereal bites (called "dragon breath puffs") that I came across near the beach are a must for future lab snacks 😎

I've been enjoying all of your introductory skeets, so here we go! I'm a neurobiologist who recently joined the ALS Therapy Development Institute after my postdoc to identify phenotypes and therapeutic targets (ie: organelle & cytoskeletal dynamics) via patient-derived neurons - such as these:

Hi "What's science"! I'm a neuronal cell biologist heading the NeuroCyto Lab in Marseille, France. We study how the nanoscale architecture of axons underlie their unique physiological functions. We image cells with advanced microscopes - these images can also be beautiful! 🧪 www.neurocytolab.org