Dorothy Crowfoot Hodgkin, biochemist & trailblazer in crystallography, she established the biomolecular structures of insulin, vitamin B12, & penicillin winning the Nobel in Chemistry in 1964 #WomensHistoryMonth #WomenInStem #WomenInScience

Nikol Zografou Barredo, PhD Student (Medicinal Chemistry), Newcastle University #facesofscience #chemsky #sciencesky

What better way to join Bluesky than post our first professional team photo. We've been busy onboarding everyone over the last few months, so welcome to Giusy, Debakshi, Kako and Gonzalo who have joined James. We're looking forward to helping our users do great cryo-EM.

Here we unexpectedly find that the ribosomal protein S20/L26—identified at the dawn of ribosome research but later deemed a biochemical artifact—is indeed a genuine component of the large ribosomal subunit. More on this ribosome content variation is here: www.nature.com/articles/s41...

New cryo-EM/ET story - a brilliant collaboration with Sergey Melnikov's lab in Newcastle @sergeymelnikov.bsky.social and Stefan Pfeffer's lab in Heidelberg @pfeffercryolab.bsky.social. Great work in particular by Karla Helena-Bueno and @sophiekopetschke.bsky.social www.nature.com/articles/s41...

We are thrilled to announce the 2025 EMBO practical course in cryo-em image processing, Birkbeck College, London, 9-16 Sept 2025. More info & apply: meetings.embo.org/event/25-cry... Organisers Giulia Zanetti & Helen Saibil. Beautiful image from co-organizer @carolynmoores1.bsky.social lab.

**deadline Mar 30th** Passionate about #cryoEM? Interested in #PhD project on allosteric mechanism of a dynamic enzyme implicated in metabolic and neurological disorders? Join @allostericstate.bsky.social and me in NCL on a funded @mosmedcdt.bsky.social studentship. www.findaphd.com/phds/project...

🎉 Today we're celebrating as 12 of our subjects have been ranked within the world's top 100 in the latest QS World University Rankings by Subject. Congratulations to all our colleagues and teams involved in this fantastic achievement👏 #WeAreNCL #QS

"CACHE Challenge 2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13" is out now on ChemRxiv: dx.doi.org/10.26434/che... You can find a discussion of our workflow and designed compound in the preprint (WF1438), which was among 13 compounds confirmed to bind to Nsp13.

**Please repost**Interested in a #PhD project on #cryoEM & enzymatic mechanism? Join @allostericstate.bsky.social and me in Newcastle on a funded @mosmedcdt.bsky.social studentship. Choose project code mos2_04 in Thomas' link below. Or go to: www.findaphd.com/phds/project...

A story of fragment screening to initiate drug discovery

Very interesting to see the 50 new drugs that made it to FDA approval in 2024 in one place. A lot of really exciting small molecule chemistry with interesting functional groups, deuterations and covalent warheads. #chemsky #chembio www.linkedin.com/posts/chrisd...

Registration for the CCP-EM Spring Symposium 23-25th April 2025 open, see www.ccpem.ac.uk/training/spr...

Great discovery of a new gene involvement in vitamin B6 metabolism

Roughly 6,000 readers answered our poll, with many declaring that Bluesky was nicer, kinder and less antagonistic to science than X https://go.nature.com/42tH8Ai

Anyone ever have any problems with bacmid transpositions continuously not working? I have been struggling to get any positive white colonies using pFastbac plasmids from Twist and even for a plasmid from another lab for a while now.

You want to build an apparatus for time-resolved cryo-EM? Easy: bio-protocol.org/en/bpdetail?...

A blue sky day for my bluesky acct www.reddit.com/r/NewcastleU...

Time to look up your favourite (human) protein in the subcellular map.

Finally updated the lab website: www.medicinesfromthesea.com

Diagnose the diagnosable and don't miss the treatable. Did you know that approximately 1 in 5 IMDs (18%) are amenable to some form of treatment? Therefore it's imperative to make the diagnosis and keep abreast of developments in the therapy space. onlinelibrary.wiley.com/doi/full/10....

Every point so true. I go further to memorise the first 2-3 lines of every slide so I feel I'm in control of the storytelling and the flow

Let's make 2025 the "Year of the Mitochondria," to stimulate more research for mitochondrial and other diseases, incite curiosity and commitment from funders to invest in mitochondria as the heart of health and a key to solving resistant diseases and conditions. @MitoWorld.org / Image: Rehman Lab

This has been published for a while but thought it a neat workflow to study metabolic enzyme filaments in cells www.cell.com/cell/fulltex...

In case you missed it on the other site, we've written up some of our experiences from the CACHE2 hit finding challenge in this blog: cole-group.github.io/2024/09/10/c... Thanks to the organisers for a well-run challenge! @creechem.bsky.social @bieniekmat.bsky.social @nataliejtatum.bsky.social

Dear world: this is what a graphical abstract is supposed to look like.

Congrats Anna on the nice AChR work @annaliiiiiiii.bsky.social

A great primer for embarking on a #medchem journey in #drugdiscovery pubs.acs.org/doi/10.1021/...

📢 Apply now for the 'Wellcome-MRC Cryo-EM in Structural Biology 2025' 📅 Join us March 03-07 at eBIC, @diamondlightsource.bsky.social & ABSL, @universityofleeds.bsky.social for fundamentals in #CryoEM & #CryoET🦠 Apply by 19 Jan - limited spots! www.diamond.ac.uk/Instruments/...

Glad to see more fellow NCLers in bluesky! #WeAreNCL

Post #1: pleased to meet you here in bluesky. Do check out our lab page: www.staff.ncl.ac.uk/yuelab/