We are losing scientists from the government at an unprecedented rate - some were fired, but many more were forced out through trauma and fear. www.science.org/content/arti...

Zarr is great and so are you

Important website nowadays downloadmoreram.com/download.html

Excited to share our newest project using spatial transcriptomics with novel image analysis approaches to investigate the impact of biological risk factors for Alzheimer's disease (AD) - APOE haplotype, sex, and genomic ancestry - on molecular states in the locus coeruleus (LC 🔵) of the human 🧠.

“It’s hard to know if I should close down my existing projects and/or redouble my efforts writing new grant applications,” Joshua Jacobs, associate professor of biomedical engineering at Columbia University, told @thetransmitter.bsky.social. By Natalia Mesa www.thetransmitter.org/funding/nih-...

Woohoo! Go Ginny!

Can't wait to read this preprint from Misha Ahrens and team. Calcium imaging in larval zebrafish, in every cell in the body! Amazing. www.biorxiv.org/content/10.1...

Here's what this means: it's probably unlawful forPOTUS to stop NIH funds from going to medical research, but POTUS can stop that medical research for a lengthy period of time while the Court of Federal Claims hears lawsuits This, essentially, destroys the capacity for medical research in the US

The ideological cancellation of $800 million of scientific research grants because they supposedly focused on DEI was just backed by the Supreme Court. This is horrific on so many levels.

Yes! Sharing neural recordings improves reproducibility and transparency, and reduces the need for new experiments - we should value it. And reuse is really happening: @steinmetzneuro.bsky.social's datasets (highlighted) have over 80k downloads! 🔥 figshare.com/authors/Nick...

Reminder that we still have time to fight this! This bill is being crafted & debated in the coming days and weeks. Organize NOW to do outreach and get people in your neighborhood contacting their reps. @standupforscience.bsky.social has resources. Instructions for Postcards-for-Science are here:

Moving my awesome @pugetsystems.com machine with the help of the legendary @aoracingusa.bsky.social Rexy. Gonna be the fastest (and safest) move ever

tl;dr — this EO co-opts the language of open science to implement a system of political control wherein presidential appointees are given broad latitude to designate any number of reasonable scientific activities and inferences as scientific misconduct, and to penalize those involved accordingly.

1. It's Fustilarian Friday and today's drop is the "Restoring Gold Standard Science" executive order. My read is that this is designed to (1) protect far-fringe figures such as the antvaxxers now heading our health agencies, and (2) kneecap efforts to use scientific evidence in regulatory policy.

🧪 Federal science funding cuts directly threaten public services. Reduced operations at NOAA, CDC, and EPA mean compromised weather forecasts, disease surveillance, and environmental safeguards.

HHMI has paused consideration for a new round of its Hanna Gray postdoc fellowship Applicants feel it's the latest step in the academic pipeline contracting 🧪 www.statnews.com/2025/05/19/h...

🚨 Over 700 previously undisclosed #NIH grant terminations were released this week, totaling $1.7B and nearly doubling our count of terminations to >1500. Diversity supplements for research awards are a huge fraction, as well as service awards and training programs. grant-watch.us/posts/700-ne...

I have learned that graphics programming is literally a miracle and I don’t understand how the hell people do this for a living. Just getting displays to refresh at appropriate time points if they aren’t at the same frame rate was so hard man.

NEW: Whistleblower records show that the NIH axed research grants – even after a federal judge blocked the cuts with an injunction. www.propublica.org/article/trum... 🧵

The bill, which was approved today by the U.S. House of Representatives and heads next to a Senate vote, includes 20 percent less BRAIN Initiative funding than last year. By @avaskham.bsky.social www.thetransmitter.org/funding/u-s-...

It's hard to say this, but science (& research more generally) is just being **stopped** in the US right now. This is just one university, losing nearly a billion dollars in project funding pretty much overnight. That's people's jobs & the research that could save lives. www.wsj.com/health/healt...

"The Trump administration has terminated $800 million in grants to Johns Hopkins University, spurring the nation’s top spender on research and development to plan layoffs and cancel health projects, from breast-feeding support efforts in Baltimore to mosquito-net programs in Mozambique."

Johns Hopkins University President Ron Daniels is preparing the Baltimore campus for the possibility of major cuts to programs and staff after seismic changes to federal funding at universities announced last month.

List includes Harvard University, George Washington University, Johns Hopkins University, New York University, Northwestern University, the University of California, Los Angeles; the University of California, Berkeley, the University of Minnesota, and the University of Southern California.

Terrific how-to on communicating the value of basic research to the public in @thetransmitter.bsky.social by @tonyzador.bsky.social. You may be curious. But when you are communicating the value of what you do, it’s not about you. Point to discoveries. www.thetransmitter.org/outreach/how...

Hi New Yorkers! Consider reaching out to Congresswoman Malliotakis, who is introducing legislation to end federal funding of animal research: malliotakis.house.gov/media/press-...

While there's a lot on this that is to be seen—impacts of the chaotic smashing of govt are coming to light in bits and pieces—from my own corner, I would suggest academic associations holding conferences in the US consult with lawyers NOW and offer support/guidance for trans members. 1/2

As someone who has spent the last 25 years studying sex differences in brain function and behavior and the last 10 advocating (loudly) for SABV and working to help my colleagues implement the policy into their work, this is utterly heartbreaking.

Check out the scientific journey behind the newest FDA-approved pain medication! 💊 Learn how NIH-funded research played a crucial role—both directly and indirectly—in bringing this breakthrough to life. 🧪

This is absolutely correct. Convo I had last week that is part of why I resigned: Much more senior leader: no, we still can't post FRNs. Me: Doesn't that mean we can't proceed? MMSL: correct Me: doesn't that mean we're not in compliance with the TROs? MMSL: ...um...yea, in a way...

🤖A novel system developed by Postdoc Dhruv Zocchi, Sr. Group Leader @mishaahrens.bsky.social & collaborators that chases larval zebrafish around an arena with predator robots is enabling scientists to understand how these days-old fish quickly learn in the real world. 🐟 🔗 hhmi.news/4bcKcDu

My research group is well funded, and I'm terrified. All scientific labs run on slim margins, typically 12-24 months from running out of $. NIH is not reviewing proposals right now- the wave of labs shutting down is looming closer. All scientists are anticipating a major precipice. Options? 1/5

National Science Foundation fires roughly 10% of its workforce www.npr.org/2025/02/18/n...

I have been talking to the media, Time, Fortune, NBC, etc., to explain how the onslaught on science and NIH will impact the health of all Americans. Everyone knows someone who has cancer, heart disease, or depression. Spread the word about how cutting science impacts all. time.com/7216299/nih-...

I wrote about how Doge is involved in cutting cancer research www.vanityfair.com/news/story/d...

Johns Hopkins officials said the NIH funding cut puts at risk approximately 600 current and ongoing clinical trials at Hopkins, including open clinical trials in cancer, pediatrics and children’s health, heart and vascular studies and the aging brain. www.thebaltimorebanner.com/education/hi...

Ok this is extremely bad, like universities will have to close bad

WTF! So starting Monday NIH indirects to all universities moved to 15%. This would cripple schools. This is madness. grants.nih.gov/grants/guide...

6. The policy does not just affect funding going forward. All existing NIH grants will have their indirect rates cut to 15% as of today, the date of issuance. For a large university, this creates a sudden and catastrophic shortfall of hundreds of millions of dollars against already budgeted funds.

This is the end of science as we know it if it stands—15% IDCs for all NIH Grants. grants.nih.gov/grants/guide...

Important thread. Read to the end. “The goal is to destroy US universities. ⬇️

Executive wants to frame the NIH indirects cut as $4B in savings. But given that NIH returns $2.5 on every $1 investment, this would actually cost US economy a net $6 BILLION (per year!). Not to mention the human costs of wrecking education and research sectors and the communities they serve.

It looks like the massive indirect rate cut from NIH is not legal--and will face judicial challenges. But for scale, look at your state, and knock off about 25% to see the damage.

Ultimately, if this were to stand, there would be two major effects: 1: a ton of people will lose their jobs, and 2: we will cede being the world leader in scientific research. There is no amount of foundation or philanthropic money can replace this.

In California NIH FUNDING: $5.31 B JOBS SUPPORTED: 55,949 ECONOMIC ACTIVITY SUPPORTED: $13.55 B KEEP IT GOING

I wish this podcast we recorded several weeks ago about the NIH would stop being relevant www.changetechnically.fyi/2396236/epis...

The entire archive of all CDC datasets uploaded before January 28th, 2025 has been backed up on Internet Archive. Incredible work everyone. Science will never be silenced!

One of my friends has a grant from the #FDA to look at disparities in clinical trial research and just submitted a manuscript with the findings. She was told today by the collaborators from the #FDA to rescind it. #Censorhip has started, we are living in authoritarian government.