📚 This T-cell NHL diagnostic slide has been circulating and provides a nice framework #medsky #hemesky #hemeonc #lymphoma #pathsky #hemepath #Tcells #cellmarkers #biology #hematology #medicine #pathology #oncology #oncsky #diagnostics #meded

Final CAPTIVATE Analysis Data Support Frontline Fixed-Duration Ibrutinib Plus Venetoclax in CLL/SLL #CLL #Hematology www.onclive.com/view/final-c...

All signed up for the 2025 ASH Annual Meeting. Looking forward to it! #hemesky #ASH25

🩸 ISTH DIC score (overt ≥ 5) Plt <50=2; 50–100=1 PT >6s=2; 3–6s=1 Fibrinogen <1.0g/L=1 D-dimer: >3× ULN=3; 1–3× ULN=2; none=0 #hemesky #medsky #coag #benignheme

Join us on October 25 for a packed day of thrombosis education for healthcare professionals. Register today at thrombosiscanada.ca/2025Conference

Mosunetuzumab/Polatuzumab Vedotin Is an Effective Off-the-Shelf Combo in R/R MCL @mdanderson.bsky.social @societyofhemonc.bsky.social #SOHO2025 #lymsm #hematology www.onclive.com/view/mosunet...

🩺 Differentiation Syndrome - complication that can occur during treatment of APL w/ ATRA+ATO Clinical: ⬆️ WBCs ⬆️ Fever ⬆️ edema/body weight/pulmonary infiltrates Mgmt: - high-dose steroids - cytoreduction - antipyretics / cxs / abx for FN - diuresis #hemesky #hemeonc #medsky #APL #APML #leukemia

Not hard to tell that I’m currently on thrombosis! Having a good experience with the team here at McMaster. #thrombosis #hemesky #hematology

"Updated definition and scoring of disseminated intravascular coagulation in 2025: communication from the ISTH SSC Subcommittee on Disseminated Intravascular Coagulation." Publié en juillet dans J Thromb Haemost. #MedSky #DIC www.sciencedirect.com/science/arti...

🩸📖 NEJM 2003: CLOT trial - 676 patients w/ cancer-associated thrombosis (CAT) - Dalteparin vs warfarin. Dalteparin dose: 200 IU/kg sc daily ×1/12 → 150 IU/kg daily ×5/12 (total 6 months). Outcome: ↓ recurrent VTE; no ↑ major bleed in the group who received dalteparin. #hemesky #thrombosis #medsky

🩸Cancer-associated Thrombosis Trials: LMWH more effective than VKAs CANTHANOX 2002: Enoxaparin vs VKA CLOT 2003: Dalteparin vs VKA ONCENOX 2006: Enoxaparin vs VKA LITE 2006: Tinzaparin vs VKA CATCH 2015: Tinzaparin vs VKA #thrombosis #clinicalTrials #hemesky #medsky #IMsky #oncology #hemeonc

CARAVAGGIO 2020 (1,170 pts): Apixaban vs dalteparin for cancer VTE. Recurrent VTE 5.6 % vs 7.9 % (non-inf). Major bleed 3.8 % vs 4.0 %; no extra GI bleed. Bottom line: apixaban noninferior to dalteparin without increase in major bleeding in cancer-associated VTE. #medsky #hemesky #thrombosis

Lesson from this past week: Isolated elevation of anticardiolipin IgM does not meet laboratory criteria for antiphospholipid syndrome! According to EULAR 2023 guidelines below. #medsky #IMsky #rheumsky #hemesky #antiphospholipid #thrombosis

Ven is effective (91% ORR) and well tolerated in octogenarians, but 43% hd treatment holds and 32% prolonged ramp-up. buff.ly/lNgBN1r #hemesky

Monoclonal Gammopathy: Paraneoplastic Neuropathy 🧠🩸 AL Amyloidosis: painful + length-dependent + sensory > motor POEMS: symmetric disabling demyelinating polyneuropathy DADS-M: distal loss of proprioception + demyelinating + coarse tremor + mild motor weakness #hemesky #myeloma #medsky #neurosky

Chronic myeloid leukemia is a myeloproliferative neoplasm. This Review summarizes the epidemiology, diagnosis, and management of chronic myeloid leukemia. https://ja.ma/4mlR6ez

Unveiling the enigma: circulating flowerlike large B-lymphoma cells in the context of angioimmunoblastic T-cell lymphoma buff.ly/bbBzTQG #hemesky #lymphoidneoplasia

🔬🩸Hemoglobin development (some fundamentals!) Embryo Hb Gower I = ζ2ε2 Hb Gower II = α2ε2 Hb Portland = ζ2γ2 Fetus HbF = α2γ2 Adult HbA = α2β2 ~97% HbA2 = α2δ2 ~2–3% HbF <1% #hemesky #medsky #IMsky #benignheme #hemoglobin #pediatrics

JAK Inhibitor–Based Combos and Mutation-Specific Regimens Comprise the Future of Myelofibrosis Management #MPNsm #hematology #oncology www.onclive.com/view/jak-inh...

Workin. CML in a 27 Year old. #haematology #hematology

💊 Abatacept Humanized protein construct from recombinant DNA (CTLA4 + IgG1 Fc) grown in hamster ovary cells. Selectively binds to CD80/86 on APCs, inhibiting CD80/86-CD28 costimulatory signal essential for full T-cell activation. #medsky #IMsky #rheumsky #biologics (Herrero-Beaumont et al., 2012)

Isatuximab Plus VRd Wins EU Approval for Newly Diagnosed, Transplant-Ineligible Multiple Myeloma #mmsm #Hematology www.onclive.com/view/isatuxi...

This recently published study highlights the prognostic significance of high-risk cytogenetic abnormalities in multiple myeloma. Genetic alterations like t(4;14), del(17p), and +1q are linked to poorer prognosis and shorter survival  #MM #hematology 👉https://bit.ly/3PzY1BT

🩸Large Granular Lymphocytic Leukemia Indolent clonal proliferation of mature cytotoxic T cells - Neutropenia/anemia - a/w autoimmunity - CD8+ T cells w/ NK cell markers - intrasinusoidal bone marrow/spleen/liver path ~50% STAT3 / STAT5b mutation #hemesky #pathsly #hemepath #IMsky #medsky #leukemia

💊 Lung Cancer FDA-approved medications in 2024 #oncsky #medsky

This episode was great! #hemesky #lymphoma #MCL

2024 approvals: Summary of 12 new 💊indications in heme malignancies by FDA: 1. #Zanubrutinib 2. #Ponatinib 3. #LisoCel x2 4. #Imetelstat 5. #Epcortimab 6. #Daratumuab 7. #Axatilimab 8. #Isatuximab 9. #Asciminib 10. #ObiCel 11. #Revumenib #HemeSky #OncSky #mmsm #leusm #MedSky #lymsm

Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1...

🩸CML Treatment #ASCO2024 1. Assess (🫀,🫁,GI,comorbs) 2. Risk strat (Sokal, Hasford, EUTOS) 3. Treatment - Low risk: Imatinib - Int/high risk: 2nd-gen TKIs 4. Monitor (bcr-abl PCR🧪) #hemesky #hemeonc #oncsky #CML #leukemia

Check out our recent feature article, which covers the late-breaking abstracts presented at #ASH24! Don't worry if you missed out - we've got you covered!📖🩸 👉https://buff.ly/3Bpau84 #LymSM #HemOnc #SickleCellDisease #MPNsm @ash-hematology.bsky.social #MedSky #BloodSky #HemeSky #HemeOnc

💊 Antiarrhythmics - Vaughan Williams Classification 🫀Class I (Ia, Ib, Ic) - Na+ Channel Blockers 🫀Class II - Beta Blockers 🫀Class III - K+ Channel Blockers 🫀Class IV - Ca2+ Channel Blockers 🫀Class V agents - Other #medsky #IMsky #internalmedicine #cardiosky

🩸AML Treatment (simplified) Here’s a nice general framework to treatment in AML! #hemesky #hemeonc #oncsky #medsky #AML #leukemia #ASCO24

🩸Anticoagulant Reversal Warfarin =🚫II,VII,IX,X Reverse = Vitamin K, 4-PCC (II,VII, IX, X) Heparin =🚫II,X Reverse = Protamine (binds heparin) Dabigatran =🚫II Reverse = Idacrucizumab (anti-dabigatran mAb) Xa inhibitors (Apixaban) Reverse = Andexanet alfa (Xa decoy & binds drug) #hemesky #medsky

Glofitamab Produces Durable Remissions in R/R Mantle Cell Lymphoma @lymphclinican.bsky.social @ash-hematology.bsky.social #ASH24 #lymsm #oncology www.onclive.com/view/glofita...

🩸 Febrile Non-Hemolytic (FNHTR): - Time: ≤ 4 hours - Cause: cytokines in donor blood - Prevention: H2 blockers, antipyretics, leukoreduction - Mgmt: stop infusion, antipyretrics, H2 blockers, meperidine (rigors), r/o other causes, notify blood bank #hemesky #medsky #IMsky #internalmedicine

At #ASH24, the IMMagine-1 trial presented promising results for anitocabtagene autoleucel (anti-BCMA CAR T-cell therapy) in relapsed/refractory multiple myeloma, showing high response rates in heavily pretreated patients. #MultipleMyeloma #CancerResearch

One thing I think about way too much is that after you die, your white blood cells keep living for up to three days pubmed.ncbi.nlm.nih.gov/8366783/. Just little security guards, wandering the apocalypse, loyal to the end, slowly realizing no one is left #Medsky #PharmSky #RxSky #hemesky #Skyence

💊 Chemotherapy: disrupting cancer cell cell growth and survival at multiple levels. This handy diagram summarizes chemotherapy classes and where they fit according to their mechanism of action ⚙️ #oncsky #hemeonc #hemesky #pharmsky #medsky #IMsky #cancer #chemo (Falzone et al., 2023. Cell)

💊 This diagram covers the ~broad spectrum~ of antibiotic activity. #medsky #IMsky #internalmedicine #IDsky #punsky #puns #emimcc

🩸Hematopoietic stem cell differentiation with cytokine regulation #hemesky #hemeonc #medsky #IMsky #internalmedicine #hemepath #pathsky #stemcells

Most viewed in the last 7 days from JAMA: Care guided by measurement of procalcitonin reduces antibiotic duration safely compared with standard care, but CRP does not. https://ja.ma/3ZDRElB

🩸Neutrophilic myelocyte Cytoplasm slightly basophilic to cream-coloured prominent red-purple azurophilic (primary) granules and numerous specific (secondary) granules nucleoli absent usually slightly indented nucleus w/ red blue and slightly condensed chromatin #hemeky #hemepath #pathsky #IMsky

🫀Cardiac tamponade vs constrictive pericarditis vs restrictive cardiomyopathy A big thanks to #IMR for this handy comparison table. Good for reference down the road or for someone like myself currently studying for the #InternalMedicine Royal College exam here in Canada. #cardiosky #medsky #IMsky

🌡️ Fever of Unknown Origin (FUO) = temp >38.3C multiple times x 3 weeks without obvious cause Infections: 20-40%. Connective tissue disorders: 20% Malignancy: 10-20% Undiagnosed: 20% Drugs (e.g., phenytoin): rare #medsky #IMsky #internalmedicine #IDsky #hemeonc #hemesky #oncsky #rheumsky

A nice handy slide from the FDA sessions at #ASH24 of CAR-T therapy approvals to date!

🫀 Mitral valve prolapse (MVP) ✨dynamic examination✨ ⬆️ preload (squatting) > murmur soft + click late ⬇️ preload (standing) > murmur loud + click early ⬆️ afterload (handgrips) > murmur loud + click late ⬇️ afterload (initial Valsalva) > murmur soft + click early #cardiosky #medsky #IMsky #emimcc

Bank of Canada reduces policy rate ntv.ca/bank-of-cana...

Canadian Prime Minister Justin Trudeau: “In just a few days, essential items will be tax-free in Canada.   Takeout for dinner. Your morning coffee. Diapers and winter snow pants for your kids. All tax-free for the next two months.    That’s going to make life cost a little less.”

5th person to be cured of HIV “Today, researchers announced the Dusseldorf patient still has no detectable virus in his body, even after stopping his HIV medication four years ago.”