🫁 Just passing on what I thought was a very nice diagram from Med G for respiratory physical examination. Always nice to have some materials on-hand for learners. #medsky #IMsky

Jorge Castillo, MD, shares data on an all-oral, non-chemo, fixed-duration regimen for Waldenström macroglobulinemia using pirtobrutinib and venetoclax. The combination delivered rapid, profound and 100% overall responses with manageable side effects and high rate of deep responses. #ASH25

Wow!! 🔥🔥 CDK4/6 inhibition prevents selection of #ClonalHematopoiesis with DNA-damage repair mutations after chemotherapy! Awesome presentation from Irenaeus Chan from @kellybolton.bsky.social lab! #ASH25

#ASH25 let’s goooooo

📚 This T-cell NHL diagnostic slide has been circulating and provides a nice framework #medsky #hemesky #hemeonc #lymphoma #pathsky #hemepath #Tcells #cellmarkers #biology #hematology #medicine #pathology #oncology #oncsky #diagnostics #meded

Final CAPTIVATE Analysis Data Support Frontline Fixed-Duration Ibrutinib Plus Venetoclax in CLL/SLL #CLL #Hematology www.onclive.com/view/final-c...

All signed up for the 2025 ASH Annual Meeting. Looking forward to it! #hemesky #ASH25

🩸 ISTH DIC score (overt ≥ 5) Plt <50=2; 50–100=1 PT >6s=2; 3–6s=1 Fibrinogen <1.0g/L=1 D-dimer: >3× ULN=3; 1–3× ULN=2; none=0 #hemesky #medsky #coag #benignheme

Join us on October 25 for a packed day of thrombosis education for healthcare professionals. Register today at thrombosiscanada.ca/2025Conference

Mosunetuzumab/Polatuzumab Vedotin Is an Effective Off-the-Shelf Combo in R/R MCL @mdanderson.bsky.social @societyofhemonc.bsky.social #SOHO2025 #lymsm #hematology www.onclive.com/view/mosunet...

🩺 Differentiation Syndrome - complication that can occur during treatment of APL w/ ATRA+ATO Clinical: ⬆️ WBCs ⬆️ Fever ⬆️ edema/body weight/pulmonary infiltrates Mgmt: - high-dose steroids - cytoreduction - antipyretics / cxs / abx for FN - diuresis #hemesky #hemeonc #medsky #APL #APML #leukemia

Not hard to tell that I’m currently on thrombosis! Having a good experience with the team here at McMaster. #thrombosis #hemesky #hematology

"Updated definition and scoring of disseminated intravascular coagulation in 2025: communication from the ISTH SSC Subcommittee on Disseminated Intravascular Coagulation." Publié en juillet dans J Thromb Haemost. #MedSky #DIC www.sciencedirect.com/science/arti...

🩸📖 NEJM 2003: CLOT trial - 676 patients w/ cancer-associated thrombosis (CAT) - Dalteparin vs warfarin. Dalteparin dose: 200 IU/kg sc daily ×1/12 → 150 IU/kg daily ×5/12 (total 6 months). Outcome: ↓ recurrent VTE; no ↑ major bleed in the group who received dalteparin. #hemesky #thrombosis #medsky

🩸Cancer-associated Thrombosis Trials: LMWH more effective than VKAs CANTHANOX 2002: Enoxaparin vs VKA CLOT 2003: Dalteparin vs VKA ONCENOX 2006: Enoxaparin vs VKA LITE 2006: Tinzaparin vs VKA CATCH 2015: Tinzaparin vs VKA #thrombosis #clinicalTrials #hemesky #medsky #IMsky #oncology #hemeonc

CARAVAGGIO 2020 (1,170 pts): Apixaban vs dalteparin for cancer VTE. Recurrent VTE 5.6 % vs 7.9 % (non-inf). Major bleed 3.8 % vs 4.0 %; no extra GI bleed. Bottom line: apixaban noninferior to dalteparin without increase in major bleeding in cancer-associated VTE. #medsky #hemesky #thrombosis

Lesson from this past week: Isolated elevation of anticardiolipin IgM does not meet laboratory criteria for antiphospholipid syndrome! According to EULAR 2023 guidelines below. #medsky #IMsky #rheumsky #hemesky #antiphospholipid #thrombosis

Ven is effective (91% ORR) and well tolerated in octogenarians, but 43% hd treatment holds and 32% prolonged ramp-up. buff.ly/lNgBN1r #hemesky

Monoclonal Gammopathy: Paraneoplastic Neuropathy 🧠🩸 AL Amyloidosis: painful + length-dependent + sensory > motor POEMS: symmetric disabling demyelinating polyneuropathy DADS-M: distal loss of proprioception + demyelinating + coarse tremor + mild motor weakness #hemesky #myeloma #medsky #neurosky

Chronic myeloid leukemia is a myeloproliferative neoplasm. This Review summarizes the epidemiology, diagnosis, and management of chronic myeloid leukemia. https://ja.ma/4mlR6ez

Unveiling the enigma: circulating flowerlike large B-lymphoma cells in the context of angioimmunoblastic T-cell lymphoma buff.ly/bbBzTQG #hemesky #lymphoidneoplasia

🔬🩸Hemoglobin development (some fundamentals!) Embryo Hb Gower I = ζ2ε2 Hb Gower II = α2ε2 Hb Portland = ζ2γ2 Fetus HbF = α2γ2 Adult HbA = α2β2 ~97% HbA2 = α2δ2 ~2–3% HbF <1% #hemesky #medsky #IMsky #benignheme #hemoglobin #pediatrics

JAK Inhibitor–Based Combos and Mutation-Specific Regimens Comprise the Future of Myelofibrosis Management #MPNsm #hematology #oncology www.onclive.com/view/jak-inh...

Workin. CML in a 27 Year old. #haematology #hematology

💊 Abatacept Humanized protein construct from recombinant DNA (CTLA4 + IgG1 Fc) grown in hamster ovary cells. Selectively binds to CD80/86 on APCs, inhibiting CD80/86-CD28 costimulatory signal essential for full T-cell activation. #medsky #IMsky #rheumsky #biologics (Herrero-Beaumont et al., 2012)

Isatuximab Plus VRd Wins EU Approval for Newly Diagnosed, Transplant-Ineligible Multiple Myeloma #mmsm #Hematology www.onclive.com/view/isatuxi...

This recently published study highlights the prognostic significance of high-risk cytogenetic abnormalities in multiple myeloma. Genetic alterations like t(4;14), del(17p), and +1q are linked to poorer prognosis and shorter survival  #MM #hematology 👉https://bit.ly/3PzY1BT

🩸Large Granular Lymphocytic Leukemia Indolent clonal proliferation of mature cytotoxic T cells - Neutropenia/anemia - a/w autoimmunity - CD8+ T cells w/ NK cell markers - intrasinusoidal bone marrow/spleen/liver path ~50% STAT3 / STAT5b mutation #hemesky #pathsly #hemepath #IMsky #medsky #leukemia

💊 Lung Cancer FDA-approved medications in 2024 #oncsky #medsky

This episode was great! #hemesky #lymphoma #MCL

2024 approvals: Summary of 12 new 💊indications in heme malignancies by FDA: 1. #Zanubrutinib 2. #Ponatinib 3. #LisoCel x2 4. #Imetelstat 5. #Epcortimab 6. #Daratumuab 7. #Axatilimab 8. #Isatuximab 9. #Asciminib 10. #ObiCel 11. #Revumenib #HemeSky #OncSky #mmsm #leusm #MedSky #lymsm

Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1...

🩸CML Treatment #ASCO2024 1. Assess (🫀,🫁,GI,comorbs) 2. Risk strat (Sokal, Hasford, EUTOS) 3. Treatment - Low risk: Imatinib - Int/high risk: 2nd-gen TKIs 4. Monitor (bcr-abl PCR🧪) #hemesky #hemeonc #oncsky #CML #leukemia

Check out our recent feature article, which covers the late-breaking abstracts presented at #ASH24! Don't worry if you missed out - we've got you covered!📖🩸 👉https://buff.ly/3Bpau84 #LymSM #HemOnc #SickleCellDisease #MPNsm @ash-hematology.bsky.social #MedSky #BloodSky #HemeSky #HemeOnc

💊 Antiarrhythmics - Vaughan Williams Classification 🫀Class I (Ia, Ib, Ic) - Na+ Channel Blockers 🫀Class II - Beta Blockers 🫀Class III - K+ Channel Blockers 🫀Class IV - Ca2+ Channel Blockers 🫀Class V agents - Other #medsky #IMsky #internalmedicine #cardiosky

🩸AML Treatment (simplified) Here’s a nice general framework to treatment in AML! #hemesky #hemeonc #oncsky #medsky #AML #leukemia #ASCO24

🩸Anticoagulant Reversal Warfarin =🚫II,VII,IX,X Reverse = Vitamin K, 4-PCC (II,VII, IX, X) Heparin =🚫II,X Reverse = Protamine (binds heparin) Dabigatran =🚫II Reverse = Idacrucizumab (anti-dabigatran mAb) Xa inhibitors (Apixaban) Reverse = Andexanet alfa (Xa decoy & binds drug) #hemesky #medsky

Glofitamab Produces Durable Remissions in R/R Mantle Cell Lymphoma @lymphclinican.bsky.social @ash-hematology.bsky.social #ASH24 #lymsm #oncology www.onclive.com/view/glofita...

🩸 Febrile Non-Hemolytic (FNHTR): - Time: ≤ 4 hours - Cause: cytokines in donor blood - Prevention: H2 blockers, antipyretics, leukoreduction - Mgmt: stop infusion, antipyretrics, H2 blockers, meperidine (rigors), r/o other causes, notify blood bank #hemesky #medsky #IMsky #internalmedicine

At #ASH24, the IMMagine-1 trial presented promising results for anitocabtagene autoleucel (anti-BCMA CAR T-cell therapy) in relapsed/refractory multiple myeloma, showing high response rates in heavily pretreated patients. #MultipleMyeloma #CancerResearch

One thing I think about way too much is that after you die, your white blood cells keep living for up to three days pubmed.ncbi.nlm.nih.gov/8366783/. Just little security guards, wandering the apocalypse, loyal to the end, slowly realizing no one is left #Medsky #PharmSky #RxSky #hemesky #Skyence

💊 Chemotherapy: disrupting cancer cell cell growth and survival at multiple levels. This handy diagram summarizes chemotherapy classes and where they fit according to their mechanism of action ⚙️ #oncsky #hemeonc #hemesky #pharmsky #medsky #IMsky #cancer #chemo (Falzone et al., 2023. Cell)

💊 This diagram covers the ~broad spectrum~ of antibiotic activity. #medsky #IMsky #internalmedicine #IDsky #punsky #puns #emimcc

🩸Hematopoietic stem cell differentiation with cytokine regulation #hemesky #hemeonc #medsky #IMsky #internalmedicine #hemepath #pathsky #stemcells

Most viewed in the last 7 days from JAMA: Care guided by measurement of procalcitonin reduces antibiotic duration safely compared with standard care, but CRP does not. https://ja.ma/3ZDRElB

🩸Neutrophilic myelocyte Cytoplasm slightly basophilic to cream-coloured prominent red-purple azurophilic (primary) granules and numerous specific (secondary) granules nucleoli absent usually slightly indented nucleus w/ red blue and slightly condensed chromatin #hemeky #hemepath #pathsky #IMsky

🫀Cardiac tamponade vs constrictive pericarditis vs restrictive cardiomyopathy A big thanks to #IMR for this handy comparison table. Good for reference down the road or for someone like myself currently studying for the #InternalMedicine Royal College exam here in Canada. #cardiosky #medsky #IMsky

🌡️ Fever of Unknown Origin (FUO) = temp >38.3C multiple times x 3 weeks without obvious cause Infections: 20-40%. Connective tissue disorders: 20% Malignancy: 10-20% Undiagnosed: 20% Drugs (e.g., phenytoin): rare #medsky #IMsky #internalmedicine #IDsky #hemeonc #hemesky #oncsky #rheumsky

A nice handy slide from the FDA sessions at #ASH24 of CAR-T therapy approvals to date!