Happy to share our latest work in collaboration with Sihan Wu and James Chen labs. We found ecDNA is not only a vehicle, but can drive oncogene super expressors that induce a unique stromal niche by AREG secretion. This rapidly leads to myCAF expansion and T cell exclusion.

Our paper online now, CAF molecular phenotypes are more conserved than we thought across organs. Plus we now know more details about apCAFs. Please check it out 👉 Cancer Cell www.cell.com/cancer-cell/...

Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify Sign the Petition: chng.it/kK2HMP5pGk "Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."

Happy to share our new #NIHfunded study! Led by Kath Oñate + crew of #WomenInSTEM 💪🏽💪🏻💪, we ID potential of normal mesenchyme to restrain #inflammation, epithelial identity, & #pancreaticcancer via KITL, a cue lost in transition to a CAF state. Now at Cancer Discovery aacrjournals.org/cancerdiscov...

🚨 2024 is coming to a close but #research on #fibroblast #functions in #cancer it’s far from done ✅. If you want to know more, have a read at our latest #review now in press @trendscancer. 👇🏼👇🏼 Fantastic job by Priscilla and Marta 🌟👏🏻. And happy 2025 to all 🫶 www.sciencedirect.com/science/arti...

Now in #Science #Immunology: Ziang Zhu, Tuoqi Wu, Chen Yao et al at UT Southwestern show that #NRF2 suppression mediated by the #redox sensor #KEAP1 is required for optimal expansion of #CD8 #TCells during chronic antigen exposure!

Multiple NCI-PSRC investigators co-authored this perspective in Cancer Research last month: #PancreaticCancer–Associated Fibroblasts: Where Do We Go from Here? aacrjournals.org/cancerres/ar... @kenolivelab.bsky.social @marasherman.bsky.social @debvendramini.bsky.social @tme-caf-ecm.bsky.social

#PancreaticCancer research starter pack. 65 of 150. Room for 85 more on this 1st starter pack. Who did I miss? go.bsky.app/FDafAW

Thank you @gabriellebrewer.bsky.social for highlighting our work in Nature Reviews Cancer, led by grad student @justeng95.bsky.social. Check out the original paper in Cell here: www.cell.com/cell/fulltex... Here's a summary thread from "the other site": x.com/PeterLyLab/s...

Single-cell resolution spatial analysis of antigen-presenting cancer-associated fibroblast niches https://www.biorxiv.org/content/10.1101/2024.11.15.623232v1

Thanks Deb! Happy to share our work on pan-cancer analysis of apCAF at an unprecedented resolution. Through this study we have a much better idea about this CAF subtype!