Tremendous resource paper from NCI-PSRC member Nina Steele on collating a single cell RNA SEQ dataset in #PancreaticCancer The dataset is now housed with the PSRC. aacrjournals.org/clincancerre...

The semi annual virtual meeting of the NCI PSRC is happening now. Here NCI highlights the top ten papers from the consortium thus far.

The incidence of #PancreaticCancer in women with a BRCA1 or BRCA2 mutation acsjournals.onlinelibrary.wiley.com/doi/10.1002/... The cumulative incidence from age 40 to 80 years was 2.2% for BRCA1 carriers and 2.7% for BRCA2 carriers. Most did not have a family history of the disease.

THE DEFINITIVE AGING ATLAS A panoramic view of cell population dynamics in mammalian aging www.science.org/doi/10.1126/... PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, sexes, and genotypes!

Follow the Associate Members of NCI-PSRC who are on 🦋 @benstanger01.bsky.social @tme-caf-ecm.bsky.social @marasherman.bsky.social @debvendramini.bsky.social @rafrancescone.bsky.social New associate members can be nominated by any of the primary investigators. www.nci-psrc.org/member.html

Recent Cancer Discovery paper by NCI-PSRC investigator @hccvpdac.bsky.social ROR2 Regulates Cellular Plasticity in Pancreatic Neoplasia and Adenocarcinoma aacrjournals.org/cancerdiscov... Important study on regulators of gastric metaplasia in early #PancreaticCancer & classical variant of PDAC.

Pancreatic cancer: Advances and challenges www.cell.com/cell/fulltex... By NCI-PSRC investigators @lyssiotislab.bsky.social @mpm-lab.bsky.social @anirbanmaitra.bsky.social

Multiple NCI-PSRC investigators co-authored this perspective in Cancer Research last month: #PancreaticCancer–Associated Fibroblasts: Where Do We Go from Here? aacrjournals.org/cancerres/ar... @kenolivelab.bsky.social @marasherman.bsky.social @debvendramini.bsky.social @tme-caf-ecm.bsky.social

Please see recent publication in Cancer Discovery from NCI-PSRC investigator Andy Aguirre at @danafarber.bsky.social Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer aacrjournals.org/cancerdiscov...

Multimodal single cell-resolved spatial proteomics reveal pancreatic tumor heterogeneity www.nature.com/articles/s41... The authors have developed Spatial and Cell-type Proteomics (SCPro), capturing the proteomes of #PancreaticCancer tumor microenvironment at single cell resolution.

Special issue of Carcinogenesis featuring a series of invited articles on advances and challenges in #PancreaticCancer research, honoring the memory of Dr. Perwez Hussein. academic.oup.com/carcin/issue

The #PancreaticCancer starter pack now has over 100 researchers, advocates and organizations engaged in pancreatic cancer research & advocacy. Please write to @anirbanmaitra.bsky.social if you need to be added. This account will maintain an updated feed of pancreatic cancer research moving forward.

Please follow the NCI #PancreaticCancer stromal reprogramming consortium on 🦋 Learn more about our program here: www.nci-psrc.org