Lynne Postovit
@drpostovit.bsky.social
📤 27
📥 27
📝 3
check out our newest preprint showing that
#dedifferentiation
in certain types of
#endometrialcancers
may be due to transcriptional chaos rather than cellular reprogramming
add a skeleton here at some point
2 months ago
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www.biorxiv.org/content/10.6...
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Cell State Chaos Underpins the Evolution of SMARCA4-Deficient Dedifferentiated Endometrial Cancer
Dedifferentiated endometrial carcinoma (DDEC) is a histologically unique cancer type, wherein well-differentiated regions lie adjacent to morphologically distinct, high-grade lesions that are histolog...
https://www.biorxiv.org/content/10.64898/2025.12.01.690470v1
2 months ago
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reposted by
Lynne Postovit
Nature Cell Biology
3 months ago
☕Watt, Dauber, Szkop et al find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.
@kwattever.bsky.social
@drpostovit.bsky.social
@ki.se
@queensuhealth.bsky.social
bit.ly/47IXjvX
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Epigenetic alterations facilitate transcriptional and translational programs in hypoxia - Nature Cell Biology
Watt, Dauber, Szkop and colleagues find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.
https://bit.ly/47IXjvX
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Our newest paper is out. Here we show that hypoxia induces epigenomic alterations that change where transcripts start. This changes the 5'UTR sequences which then regulate translational efficiency. We think that this is an important regulator of the hypoxic proteome
www.nature.com/articles/s41...
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Epigenetic alterations facilitate transcriptional and translational programs in hypoxia - Nature Cell Biology
Watt, Dauber, Szkop and colleagues find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms.
https://www.nature.com/articles/s41556-025-01786-8
4 months ago
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