☕Watt, Dauber, Szkop et al find that H3K4me3 remodels 5′UTR selection in hypoxia and that this process is independent of HIF-1 transcriptional mechanisms. @kwattever.bsky.social @drpostovit.bsky.social @ki.se @queensuhealth.bsky.social bit.ly/47IXjvX

Our newest paper is out. Here we show that hypoxia induces epigenomic alterations that change where transcripts start. This changes the 5'UTR sequences which then regulate translational efficiency. We think that this is an important regulator of the hypoxic proteome www.nature.com/articles/s41...