Adnan Halim
@handle.invalid
📤 168
📥 113
📝 13
reposted by
Adnan Halim
Chris Ashwood
4 months ago
Pleased to share our native glycomics workflow preserving O-acetylation, detecting this labile modification in rat (53%) and mouse (9%) serum N-glycans. Integrally, O-acetyls are invisible under standard reductive conditions. Now published at Molecular Omics. Link:
academic.oup.com/molecular-om...
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Native PGC-LC–MS profiling reveals distinct O-acetylation patterns of Sialylated N-glycans across mammalian sera
Abstract. O-acetylation of sialic acids represents an additional layer of structural diversity and biological complexity, occurring at various hydroxyl pos
https://academic.oup.com/molecular-omics/advance-article/doi/10.1093/molecular-omics/aaiag010/8509913?utm_source=authortollfreelink&utm_campaign=molecular-omics&utm_medium=email&guestAccessKey=27cd0a14-d70d-4111-b935-52669dc39477
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Came in to work early and was met by this sunrise over Copenhagen
5 months ago
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reposted by
Adnan Halim
Luke Gamon
8 months ago
Quick heads up - there will soon be a job posting for a Staff Scientist / Senior Staff Scientist in our lab in Copenhagen to support all our mass spec proteomics adventures! Great colleagues, lots of cool projects… and you’ll get to work with me 😅 Please DM if you’re interested!
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Looking forward to try this out for N- and O-glycans from
@protifi.bsky.social
8 months ago
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reposted by
Adnan Halim
Chris Ashwood
8 months ago
Big day for foundational glycoRNA research, with two preprints published in Nature EMM. Both urge greater analytical rigour in the field. 1. RNA-associated glycoconjugates highlight potential ambiguities in glycoRNA analysis 2. Proteins are a source of glycans found in preparations of glycoRNA
add a skeleton here at some point
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reposted by
Adnan Halim
Hiren Joshi
9 months ago
Come work with
@galn.ac
and
@manno.se
every day, and the
@glyco.me
as a whole!
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I (still) handle advanced mass spec instruments in the lab. Pack columns, optimize chromatography. Design and perform complicated experiments that span weeks, sometimes months. Yet, my wife doesn’t trust me with the washing machine 😣
11 months ago
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Together with
@glyco.me
,
@bandolab.bsky.social
and teams, we recently uncovered a link between pediatric brain tumors, POMT1/2 enzymes and KIAA1549 - full story in the preprint below:
www.biorxiv.org/content/10.1...
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O-mannosylation and protein maturation check-points represent therapeutic opportunities in BRAF fusion protein oncogenesis
Fusions between protein-coding genes are common oncogenic drivers across cancers, typically pairing a proto-oncogene with partner that does not independently drive cancer. In all therapeutically actio...
https://www.biorxiv.org/content/10.1101/2025.08.18.670743v1
11 months ago
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reposted by
Adnan Halim
Chris Ashwood
over 1 year ago
Recently came across this during lit review. A solid mechanistic study with a big performance improvement as a result.
www.sciencedirect.com/science/arti...
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Addressing NHS chemistry: Efficient quenching of excess TMT reagent and reversing TMT-over labelling in proteomic samples by methylamine
N-Hydroxysuccinimide (NHS) ester chemistry is used extensively across proteomics sample preparation. One of its increasingly prevalent applications is…
https://www.sciencedirect.com/science/article/pii/S1535947625000465
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The outfit is a subtle hint: O-Man, O-GalNAc with some GlcNAc 🟢🟨🟦
add a skeleton here at some point
over 1 year ago
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Impressive study from Heck lab
www.nature.com/articles/s41...
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In-depth plasma N-glycoproteome profiling using narrow-window data-independent acquisition on the Orbitrap Astral mass spectrometer - Nature Communications
While DIA has advanced standard proteomics, its application in glycoproteomics has remained limited. Here, the authors present an optimized narrow-window DIA method for N-glycopeptides, nGlycoDIA, ena...
https://www.nature.com/articles/s41467-025-57916-1
over 1 year ago
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reposted by
Adnan Halim
Gene Chong
over 1 year ago
It’s
#glycotime
Fucosyltransferases FUT10 and FUT11 are protein O-fucosyltransferases (POFUTs) modifying proteins with elastin microfibril interface (EMI) domains. Curious to know the function(s) of O-fucosylating EMI domains
www.nature.com/articles/s41...
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FUT10 and FUT11 are protein O-fucosyltransferases that modify protein EMI domains - Nature Chemical Biology
FUT10 and FUT11, originally annotated as α1,3-fucosyltransferases, are actually protein O-fucosyltransferases participating in a non-canonical ER quality control pathway for EMI domain-containing prot...
https://www.nature.com/articles/s41589-024-01815-x
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Check out the cool handle
@manno.se
that
@glyco.me
set up for me. Thx Hiren, we all know 🟢🟢🟢 is the coolest sugar 😁
over 1 year ago
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reposted by
Adnan Halim
Anne Imberty
over 1 year ago
Still time to register to awsome Glycobiology Gordon Research Conference 2025. We have a fantastic line of speakers and this will be top
#glycotime
in Tuscany !! Register at
www.grc.org/glycobiology...
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reposted by
Adnan Halim
Hiren Joshi
over 1 year ago
New bit of work from CCG, with our newest cellular framework - GlycoCarrier
www.nature.com/articles/s41...
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Mammalian cell-based production of glycans, glycopeptides and glycomodules - Nature Communications
Access to defined human glycans is crucial for biomedical research. Here, authors report Glycocarriers, a mammalian cell-based method for the sustainable and scalable production of O-, N-glycans, and ...
https://www.nature.com/articles/s41467-024-53738-9
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