Ben Nicolet
@bnicolet.bsky.social
📤 792
📥 676
📝 15
Postdoc @ Schumacher lab, immunology, ML, TCR, Amsterdam
Can you boost the protein expression in specific cell types? That is what we asked in our study published a week ago in @scienceadvances We used machine learning (AI) to learn the code for protein expression in immune cells.
www.science.org/doi/10.1126/...
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Learning the sequence code of protein expression in human immune cells
SONAR informs the design of cell type–specific protein expression in human cells.
https://www.science.org/doi/10.1126/sciadv.ads0510
3 months ago
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reposted by
Ben Nicolet
Monika Wolkers
4 months ago
it is finally out! 👇 our
#ML
pipeline SONAR, which can predict the protein abundance in
#immune
cells. Using sequence features present in the
#RNA
. With
@bnicolet.bsky.social
Supported by the
@erc.europa.eu
[email protected]
www.science.org/doi/epdf/10....
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Learning the sequence code of protein expression in human immune cells
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https://www.science.org/doi/epdf/10.1126/sciadv.ads0510
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reposted by
Ben Nicolet
Schumacher Lab
6 months ago
It's not the models, it's the data! We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models.
www.biorxiv.org/content/10.1...
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A functionally validated TCR-pMHC database for TCR specificity model development
Accurate prediction of TCR specificity forms a holy grail in immunology and large language models and computational structure predictions provide a path to achieve this. Importantly, current TCR-pMHC ...
https://www.biorxiv.org/content/10.1101/2025.04.28.651095v2
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Getting inspired at the EMBL sustainability event!
7 months ago
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Super grateful and happy to be part of MATCHMAKERS team of
@cancergrand.bsky.social
:
bit.ly/4iN1dY9
(And thanks to CGC for the opportunity to talk about my work!)
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Tackling one of immunology’s greatest questions
Future Leaders Spotlight: Meet MATCHMAKERS with Benoit Nicolet.
https://bit.ly/4iN1dY9
10 months ago
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Super grateful and happy to be part of MATCHMAKERS team of
@cancergrand.bsky.social
:
bit.ly/4iN1dY9
(And thanks to CGC for the oppressed to talk about my work!)
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Tackling one of immunology’s greatest questions
Future Leaders Spotlight: Meet MATCHMAKERS with Benoit Nicolet.
https://bit.ly/4iN1dY9
10 months ago
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reposted by
Ben Nicolet
Monika Wolkers
11 months ago
add a skeleton here at some point
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(Repost from EMBO on x) Rethinking
#sustainability
in
#science
: read about three projects on consumption and waste of shortlisted candidates for the EMBO Lab Sustainability Award
embo.org/people/rethink…
@CanigovaNikol
a @bnicolet.bsky.soci
al @SELS_Network
11 months ago
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reposted by
Ben Nicolet
Itai Yanai
11 months ago
genomebiology.biomedcentral.com/articles/10....
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A hypothesis is a liability - Genome Biology
https://genomebiology.biomedcentral.com/articles/10.1186/s13059-020-02133-w
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Looking forward to attend this great meeting!
add a skeleton here at some point
12 months ago
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reposted by
Ben Nicolet
Evelina Tutucci
12 months ago
New preprint 📣📣 Together with Monika Wolker's lab @sanquin Amsterdam, we optimized a smFISH protocol for T cells. We measured cytokines IFNG/TNF expression and localization during T cell activation and optimized an imaging pipeline for quantification.
www.biorxiv.org/content/10.1...
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Single molecule imaging of transcription dynamics, RNA localization and fate in T cells
T cells are critical effector cells against infections and malignancies. To achieve this, they produce pro-inflammatory cytokines, including IFN-gamma and TNF. Cytokine production is a tightly regulat...
https://www.biorxiv.org/content/10.1101/2024.11.11.622939v1
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www.embo.org/people/inspi...
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Inspired by nature – People – EMBO
Insights into projects from the shortlist for the EMBO Lab Sustainability Award and the candidates’ motivation
https://www.embo.org/people/inspired-by-nature/
12 months ago
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reposted by
Ben Nicolet
Rod Rahimi
12 months ago
Wonderful to see the
#immunology
community growing here. The first starter pack is full (they cap at 150), so I created a second one. Let me know if you'd like to be added
go.bsky.app/PY5tCas
go.bsky.app/FmERUoD
add a skeleton here at some point
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Fascinating!
www.pnas.org/doi/full/10....
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PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
https://www.pnas.org/doi/full/10.1073/pnas.2308511120
about 2 years ago
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