Every so often I google something and the top hits are Reddit threads from 10-15 years ago - which doesn’t seem that long ago, but everything about the slang and typing style and general vibe feels like falling into a time warp.

Am I the only one who always feels like I have to praise the LLM whenever it does a good job? Who's a good boy? Is Claude a good boy?

This! And at the risk of going back to the messaging issue… resist the temptation to speak nonprofitese about it. Yes: “Free eggs from the Democrats” No: “Amplifying the voices of marginalized communities by expanding access to traditional foodways impacted by capitalist climate injustice”

I get wanting to reduce government inefficiency, but starting with foreign aid and biomedical research is crazy. The TSA is right there!

Have to admit I was expecting the “find out” phase of Trump 2.0 to start later than week 2.

Machine Learning in Drug Discovery Resources page updated for 2025. github.com/PatWalters/r...

I spent a long time building a dataset, finally started training a model on it, and was so relieved to see the loss go down. Maybe the data sucks, maybe the model will suck, but at least I didn’t scramble the labels or make unusable data mud.

If the worst thing that happens in Trump admin 2.0 is that he's super corrupt and scams some crypto bros, we will be getting off easy. In fact we should encourage him to spend as much of his time as possible on crypto.

I have a new blog devoted to medicinal chemistry in which I will mainly focus on classic papers. My first installment describes the design and discovery of the amazing atorvastatin: a triumph of simple modeling, dogged synthesis and leadership decisions medchemash.substack.com/p/classics-i...

I accidentally put a cat toy in the washing machine and now the whole laundry pile smells like I used catnip-scented detergent.

Going to a musty basement and turning those big cranks to move the stacks in the library Rewinding a cassette with a pencil Blowing on a video game cartridge even though you kind of suspected it was just a placebo

It's like Zuckerberg is doing a Buscemi "Hello fellow Trumpers" gif.

He’s getting divorced isn’t he

Fight! Fight! Fight! I'll have to take Elon's side on this one, despite Bannon's doubtlessly sincere DEI concerns.

Check out our work, where we discover how receptor GPCR senses pH! We solved a longstanding question by developing foundational GPCR DMS tech dev + structural bio! Led by brilliant PhD student @matthewkhoward.bsky.social and Nick Hoppe w/ @amanglik.bsky.social! www.cell.com/cell/fulltex...

Maybe the problems I give them are too easy, but whenever I ask an LLM to generate some code, the results are fine. No need for super elaborate custom prompts or a ton of back and forth.

I’m happy to see more outdoor markets in SF, but come on. If the hours are 3-7pm it is not a “night market”, even in Noe Valley.

Went to a yoga class slightly hungry. By the end I spent the entire shavasana thinking about the burrito I was going to get after class. Mmm, burrito meditation….

Here's a year-end update from #PLINDER. It's been really great working on this project and all the other projects that it has kickstarted - the gift that keeps on giving. Happy holidays everyone! www.plinder.sh/blog/updates

Good thing flight tracker sites exist so you can stress about how the plane assigned to your flight is late two legs before yours.

Just finding us here? Endpoints News has a starter pack with our journalists so you can follow the team! go.bsky.app/NzDRUhL

Both cats are in my lap at the same time. That’s 24.5 pounds of cat. That is so much cat.

Do any of the big LLMs do gift subscriptions? Seems like OpenAI is a no. I hope at least one of these companies thought of this before Christmas.

Protenix, the AF3 reproduction made by TikTok's parent company ByteDance, is now available for commercial use with an Apache 2.0 license

I updated from a super old android phone to a new iPhone and I’m perversely fascinated by how the mix of ads I get has completely changed. Apparently I’m a much higher value customer now, and also willing to pay more for stuff.

Everyone in the anti-aging/lifespan extension space talks about the value of sleep and advises getting more. As much as I enjoy sleeping, reducing sleep needs would get you so much more actual life in your existing lifespan.

Somewhere there's a bunch of silicon-based life forms talking about how carbon-based meatware is fine for eating and reproducing, but a few pounds of low-energy jello is inherently incapable of reasoning and can't possibly scale enough for consciousness no matter how interconnected it gets.

Spicy! Good points on benchmarks and splits. When I read it I thought, if you're going to be that spicy you need a figure 8 showing how "competently run" docking does on the hard set from figure 7.

I just tried this and it worked the first time with no setup fuss or dependency annoyances or anything, just did exactly what the docs said it would do. That's so rare I have to celebrate it!

Three BioML starter packs now! Pack 1: go.bsky.app/2VWBcCd Pack 2: go.bsky.app/Bw84Hmc Pack 3: go.bsky.app/NAKYUok DM if you want to be included (or nominate people who should be!)

Is apple intelligence good? I never hear anyone talk about it other than to post funny mistakes in summarizing someone's texts

New blogpost: The ABCs of Alphafold 3, Boltz and Chai-1 blog.booleanbiotech.com/alphafold3-b...

Proudly over one year (!!) under review. @chemrxiv.bsky.social preprint: "AIMNet2: A Neural Network Potential to Meet your Neutral, Charged, Organic, and Elemental-Organic Needs". Loooong time in the works...so excited to share this with #compchem #chemsky chemrxiv.org/engage/chemr...

It's a little3 hard to disagree with people who say the vibe is off around here when there's a parade of posts being performatively shocked that someone downloaded some public data from this website and put it on a different website.

My worst Thanksgiving take: I don't really like either pumpkin or pecan pie. Apple is the clearly superior fall pie.

I actually kind of like the look of the cybertruck (yes, I'm aware I have terrible taste) but seeing them try to do normal car things is so goofy. I'm watching one attempt to parallel park right now and doing my best to pretend I'm laughing at something on my phone and not this guy's parking job.

This should go chiral

One thing I think I missed about the whole Cassava story is why they had so many very online superfans. People inside getting mad about negative stories, OK, but most biotechs don't really have a fan club?

Two BioML starter packs now: Pack 1: go.bsky.app/2VWBcCd Pack 2: go.bsky.app/Bw84Hmc DM if you want to be included (or nominate people who should be!)

That cofactor deserves it.

I made a MD starter pack! Dm or reply to be added ☺️☺️ go.bsky.app/QQjPjbL

I liked grad school! What made it work: 1) Liked where I lived. Hard to beat spending your 20s in NYC 2) Had a well-paid real job first: time to figure out post-college adulting and save some money 3) Chose a program with minimal requirements (classes, TAing) 4) PI, lab, and project were great

I am not a synthetic chemist and I am SO bad at this

This is a good point. I've gotten into the habit of using twitter likes as bookmarks for things to read later, but maybe other people have similar bookmark tastes. On the other hand I don't like to follow people who retweet constantly and rarely contribute anything original.

A lot of the posts on bluesky are still posts *about* bluesky. Needs to get less meta if this is going to take off. Yes, I know I'm contributing to the problem!

I am excited to announce publication of our latest BindingDB update paper! academic.oup.com/nar/advance-... Please repost, as I am *just* getting started on BlueSky-- thanks!

I hate cofactors. Are you part of the receptor or are you a ligand? Make up your mind!

Starting to think this app needs a starter packs starter pack. Some good ones (COI: I am in them, so they must be good) AI in science: go.bsky.app/JeFdryY Drug development: go.bsky.app/B2pzQm2 Women in chem: go.bsky.app/LjumNEg

What do you call posting on this website, I'm not sure I can unironically say "skeets"