Excited to share our new paper in @chemistryeurope.bsky.social. We designed shape-shifting tetralactam macrocycles that switch from low- to high-affinity binding upon protonation, delivering >10⁵-fold enhancement for BrIBr⁻ recognition. bit.ly/4qdtGZR

Very much looking forward to our publishing workshop at Heinrich Heine University Düsseldorf on November 24. Big thank you to @sander1507.bsky.social and @daumannl.bsky.social for organizing this event!

Roman Renter, from Exciting Instruments, presenting their instrument - "Adding Dynamics to Structural Biology - Easy-to-Use Single-Molecule Tools to Bring Static Biomolecular Models to Life " #ChemBioPhys2025 #CBCCPC25 #ChemBioChem #ChemPhysChem #ChemistryEurope #Happy25

First talk of the afternoon, Sandrine Lévêquer-Fort is showing us her impressive developments in "Taking Advantage of Alternative Fluorescence Properties in Single Molecule Localization Microscopy" #ChemBioPhys2025 #CBCCPC25 #ChemBioChem #ChemPhysChem #ChemistryEurope #Happy25

"Unlocking the Secrets of Heart Muscle Structure", by Stefan Raunser #ChemBioPhys2025 #CBCCPC25 #ChemBioChem #ChemPhysChem #ChemistryEurope #Happy25

Final communication of this first afternoon session is given by Jan Götze, on FRET-Based Models Unveil Functional Roles of Photosynthetic Complexes, at #ChemBioPhys2025 #CBCCPC25 #ChemBioChem #ChemPhysChem #ChemistryEurope #Happy25

Claus Seidel, at #ChemBioPhys2025, presenting FRET Spectroscopy and Nanoscopy Resolve the Structure and Dynamics of Biomolecules at the Single-Molecule Level #CBCCPC25 #ChemBioChem #ChemPhysChem #ChemistryEurope #Happy25

Kathrin Lang is giving a fascinating closing Plenary Lecture on "Expanding the Genetic Code - New Tools for Biology" - What a conclusion for #ChemBioPhys2025 #CBCCPC25 -#ChemBioChem & #ChemPhysChem 25th anniversary - #ChemBioEurope #Happy25

Interesting talk by Claus Seidel at #ChemBioPhys2025. He talked about the use of Förster resonance energy transfer (FRET) to understand the dynamics and function of transient states in single enzyme molecules. www.nature.com/articles/s41...

#ChemBioPhys2025 comes to a close with an exciting lecture by @klanglab.bsky.social. Genetic code expansion to site-specifically study PTMs in cells. Great insights into hijacking an ABC transporter to increase uptake for many exciting amino acids. www.nature.com/articles/s41... #ChemSky #ChemBio

@rubenragg.bsky.social and Meghan Lucas close a great #ChemBioPhys2025 symposium and present the poster prizes. Congratulations to the winners. Very curious to see, what the next 25 years of ChemBioChem and ChemPhysChem of @chemistryeurope.bsky.social will bring. #ChemSky #ChemBio

I had an amazing time at the 25th anniversary symposium of ChemBioChem and ChemPhysChem #ChemBioPhys2025. We had two days of exciting science and important interactions. Thank you to the organizers from @chemistryeurope.bsky.social and especially to @rubenragg.bsky.social. #ChemSky #ChemBio

Interesting talk by Jan Götze at #ChemBioPhys2025. He gave exciting insights into his group's research into the importance of Förster resonance energy transfer (FRET) in the photosynthetic complexes. pubs.acs.org/doi/10.1021/...

The second day of #ChemBioPhys2025 is off to a great start with an exciting presentation by @gassergroup.bsky.social. He is telling us about the power of metal complexes for diagnostic and therapeutic applications. (1/4) #ChemBio #ChemSky #DrugDiscovery #diagnostics #metal

Great talk by Harald Schwalbe at #ChemBioPhys2025. He talked about the use of NMR to study the structure of #RNA on the example of #SARSCoV2. (1/3) academic.oup.com/nar/article/...

Interesting talk by @ezgikaraca.bsky.social at #ChemBioPhys2025. She talked about the use of AI for predictions of protein structures with a lot of exciting insights into the CASP competition and into the prediction of protein-protein interactions. www.biorxiv.org/content/10.1...

A truly inspiring talk by Stephen B. H. Kent at #ChemBioPhys2025. He talked about his group's many contributions to protein synthesis and crystallization. (1/5) #ChemBio #ChemSky #StructuralBiology

Interesting talk by Joseph Braymer at #ChemBioPhys2025. He talked about the huge importance of FeS clusters for biology and how he studies their biogenesis using EPR and Mössbauer spectroscopy. www.sciencedirect.com/science/arti... www.biorxiv.org/content/10.1...

Interesting talk by Hsuan-Ai Chen at #ChemBioPhys2025. She talked about the work in the Claudia Höbartner lab (@chlab.bsky.social) on the development of nucleic acid-alkylating ribozymes. (1/2) www.nature.com/articles/s41... #ChemSky #ChemBio #RNA #Ribozyme

Exciting lecture by @borisvauzeilles.bsky.social at #ChemBioPhys2025. He gave exciting insights into his group's work of using synthetic #OrganicChemistry to develop new tools to study #biology. (1/4)

In the final lecture of the morning session at #ChemBioPhys2025, @romanrenger.bsky.social from Exciting Instruments talked about, how they add dynamics to structural biology using smFRET and FCCS. academic.oup.com/nar/article/... #ChemSky #ChemBio #DrugDiscovery

After the lunch break, #ChemBioPhys2025 continues with an excellent lecture by Sandrine Lévêque-Fort (@slfort.bsky.social). She talked about exciting single-molecule microscopy technologies using modulated illumination with great 3D resolution. www.nature.com/articles/s41...

Exciting lecture by Stefan Raunser (@raunser-lab.bsky.social) at #ChemBioPhys2025. He talked about his group's amazing science to better understand actin filament disassembly to better understand muscle function. (1/2) www.cell.com/cell/fulltex... #ChemBio #ChemSky #cryoEM #muscles

Now on stage Ezgi Karaca, for a very interesting talk on "AI Revolution in the Structure Prediction of Biomolecular Complexes" #ChemBioPhys2025 #CBCCPC25 #ChemBioChem #ChemPhysChem #ChemistryEurope #Happy25

Facscinating talk by Stephen Kent on "Racemic and Quasi-racemic Protein X-ray Crystallography Enabled by Chemical Protein Synthesis" at #ChemBioPhys2025 #CBCCPC25 #ChemBioChem #ChemPhysChem #ChemistryEurope #Happy25

It was a huge pleasure to host the morning session of #ChemBioPhys2025. A huge thank you to the speakers @gassergroup.bsky.social, Harald Schwalbe, @ezgikaraca.bsky.social, Stephen Kent, Joseph Braymer, Hsuan-Ai Chen, @borisvauzeilles.bsky.social and @romanrenger.bsky.social. I learned a lot!

This morning session continued with an Oral communication by Joseph J. BRAYMER, showing how "Yeast [FeFe]-Hydrogenase-like Protein Nar1 Binds a [2Fe-2S] Cluster" #ChemBioPhys2025 #CBCCPC25 #ChemBioChem #ChemPhysChem #ChemistryEurope #Happy25

The next communication was given by Hsuan-Ai Chen on "Structure and Catalysis of the Alkyltransferase Ribozyme Samuri" #ChemBioPhys2025 #CBCCPC25 #ChemBioChem #ChemPhysChem #ChemistryEurope #Happy25

Today's morning session started with Gilles Gasser, presenting a stunning overview of "Radiometals in Nuclear Medicine" #ChemBioPhys2025 #CBCCPC25 #ChemBioChem #ChemPhysChem #ChemistryEurope #Happy25

A very inspiring talk by Harald Schwalbe: "Following 25 Years of ChemBioChem: Towards the Development of Low Molecular Weight Inhibitors Targeting Viral RNA - A Combined NMR/Med Chem Approach" #ChemBioPhys2025 #CBCCPC25 #ChemBioChem #ChemPhysChem #ChemistryEurope #Happy25

Very happy to be in Berlin to discuss about some of applied work on nuclear medicine. Many thanks to @rubenragg.bsky.social for the invitation.

@rubenragg.bsky.social opens the #ChemBioPhys2025 symposium in Berlin. Looking forward to two days of exciting science. #Chemistry #ChemSky #ChemBio #Biophysics #ChemBioChem #ChemPhysChem CC: @chemistryeurope.bsky.social

Deeply learning from fascinating Francesca Grisoni on "Exploring Chemical Space with Deep Learning in Low-Data Scenarios" at #CBCCPC25 #ChemBioChem #ChemPhysChem #ChemistryEurope #Happy25

"Design and Synthesis of New Glycerophospholipids Probes to Explore the Lipidomic", new and original probes by Sébastien Balieu at #CBCCPC25 #ChemBioChem #ChemPhysChem #ChemistryEurope #Happy25

Very informative talk on evolution of proteins, the last of this superb first day, by Lynn Kamerlin on "Harnessing Conformational Dynamics in Enzyme Engineering and Evolution" #CBCCPC25 #ChemBioChem #ChemPhysChem #ChemistryEurope #Happy25

Interesting talk by @fragrisoni.bsky.social at #ChemBioPhys2025. She talked about her group's exciting research into exploring the vast chemical space for #DrugDiscovery using #ArtificialIntelligence in low-data scenarios. www.nature.com/articles/s43... #ChemBio #ChemSky

The first day of #ChemBioPhys2025 comes to a close with an inspiring lecture by @lynnkamerlin.bsky.social. She talked about her group's research into the importance of conformational dynamics for enzyme engineering and #evolution. www.nature.com/articles/s41... #ChemSky #ChemBio

Great talk by @uendesfelder.bsky.social at #ChemBioPhys2025. She talked about her group's work on single molecule microscopy to study structure and dynamics in biological systems. Exciting insights into kinetochore structure and bacterial injectisome dynamics (T3SS). rupress.org/jcb/article/...

Amazing talk by Nobel laureate Stefan Hell @stefanhelllabs.bsky.social at #ChemBioPhys2025. He talked about the MINFLUX super-resolution microscopy technology. Exciting applications to measuring distances between fluorophores on the single-digit nm scale. (1/2) www.science.org/doi/10.1126/...

Ulrike Endesfelder presenting "Single-Molecule Microscopy as a Quantitative Tool for Biochemical and Cell Biological in Vivo Studies in (Micro)Biology - Yes, quantitative! #CBCCPC25 #ChemBioChem #ChemPhysChem #Happy25

Now on stage, Prof. Stefan Hell, recipient of the Nobel Prize in Chemistry in 2014, on "Molecule-Scale Resolution and Dynamics in Fluorescence Microscopy " - Fascinating use of a little demon to go beyond Abbe diffraction limit #CBCCPC25 #ChemBioChem #ChemPhysChem #ChemistryEurope #Happy25

Veronica Dodero on "Molecular Self-Assembly of Gluten Peptides into Nanostructures and their Interaction with Actin in Human Cell Models" at #CBCCPC25 #ChemBioChem #ChemPhysChem #ChemistryEurope #Happy25

Busra KAYA, "Targeting Lysosomes by Design: Novel N-Acridine Thiosemicarbazones that Enable Direct Detection of Intracellular Drug Localization and Overcome P-Glycoprotein (Pgp)-Mediated Resistance" at #CBCCPC25 #ChemBioChem #ChemPhysChem #ChemistryEurope #Happy25

Joan-Carles ESCOLANO from BRUKER NANO GMBH, on "Visualizing Molecular Dynamics with High-Speed Tip-Scanning Atomic Force Microscopy", at #CBCCPC25 #ChemBioChem #ChemPhysChem #ChemistryEurope #Happy25

Inspiring talk by Johannes Broichhagen at #ChemBioPhys2025. He talked about the power of organic chemistry to optimize fluorophores for biological applications. Exciting insights into the effects of fluorophore deuteration. pubs.rsc.org/en/content/a... pubs.rsc.org/en/content/a... #ChemSky #ChemBio

Johannes Broichhagen using "Organic Chemistry to Shine Light on Biology" at #CBCCPC25 in Berlin - What a brilliant start to this 25th anniversary symposium - Happy 25 #ChemBioChem and #ChemPhysChem #ChemistryEurope #Happy25

Teresa Carlomagno showing us what "integrative" really means in "Integrative Structural Biology" - "An Integrative Structural Biology Approach to Understand Functional Mechanisms I nBiological Complexes" - #CBCCPS25 #ChemBioChem #ChemPhysChem #ChemistryEurope

#ChemBioPhys2025 is off to a great start with a talk by Teresa Carlomagno. She talked about NMR to study the structure of proteins especially in cases, in which multiple conformation exist simultaneously. www.nature.com/articles/s41... #ChemSky #ChemBio #Biophysics #ChemBioChem #ChemPhysChem

Kicking off our ChemBioChem/ChemPhysChem 25th anniversary symposium with the talk by Teresa Carlomagno. Looking forward to two great days packed with amazing speakers!!! #ChemBioPhys25 @chemistryeurope.bsky.social

⚠️ Final program online now! Student registration has been reduced! ⚠️ Celebrate 25 Years of ChemBioChem & ChemPhysChem Advances in Structural Analysis of Biomolecules 📅 October 23–24, 2025 | Charité, Berlin, Germany www.cbc-cpc2025.org #ChemBioChem #ChemPhysChem #EFMC #ChemBio