Great work for psychedelic research to overcome RCT-based epistemic authoritarianism, led by @sdmuthu.bsky.social and @tehseennoorani.bsky.social 👏👏👏. Thankful for the invite to to collaborate, together with @trpwolff.bsky.social, @mattbagg.bsky.social and others. osf.io/preprints/ps... 🧪🧠💊

Yet another pointless (scientifically speaking) study of psychedelics. With no placebo response the design is clearly a mess. I guess you can juice your stock price but you’ll never see this get published … and if you don’t publish your participant information sheets then don’t bother ….

Please god. No more systematic reviews of psychedelics .... (at least for a while 😅)

This won’t be a popular view on the left but as a clinical trialist I am not sad to see the TPA go. The current clinical trial system works pretty well actually but the TPA had lots of uncertainty/undefined things in it - definitions that could have been really bad….

Always exciting to receive the investigational product for a new clinical trial. First time I’ve had one go through a ceremonial blessing process (karakia and waiata) though … (see below for details).

We’ve done this is humans. Paper in submission …

Interesting new study on "personality" change due to psilocybin administration. Lots in here, but just focusing on one element, they found that psilocybin in the lab reduced neuroticism, but not any other aspect of the Big 5. www.sciencedirect.com/science/arti... #psychedelicscience

Complexity in MEG/EEG. My prediction is that a good number of results are not actually showing changes in brain “complexity” but reflect spectral power changes - failing to use surrogate data properly. Some bright PhD/PostDoc should do this. Will make a great paper. I’m too time poor else I would…

I’m not a sociologist but was introduced to this fabulous paper - Becker (1953) “Becoming a marihuana user”. Sometimes the archives of academia are amazing! www.jstor.org/stable/2771989

Psychopharmacology gets lots of criticism from psychotherapy/adjacent folks. But if someone could send me therapy trials that 1. Are double-triple blind 2. Carefully document/report AEs 3. Pre-register an SAP with ITT I would appreciate. I will wait ….

I feel my initial post on the Dodo bird may have been completely side-tracked into a debate on the MAPS model (which at the end of the day doesn’t much interest me)…. But at least some discussion because honestly blue sky has been kind of dull so far …

Been reading quite a bit of psychotherapy research lately. If one accepts the Dodo Bird Verdict (which is not an unreasonable position) then it really doesn’t matter what type of therapy is used in PAT (as long as not harmful) even if that therapy is based on odd principles …

Re-posting this pre-print because a) New version b) Actually have followers on here now 😅 “Tū Wairua: Development of an Indigenous Rongoā Māori Approach to Healing with Psilocybin Containing Mushrooms” Check it out. IMHO a unique project and I have learnt a lot from it. osf.io/preprints/ps...

Klein (1996). “The bottom line is that if the FDA was responsible for the evaluation of psychotherapy then no current psychotherapy would be approvable”. Dude didn’t hold back !

Seen Māori protests/haka on social media? Seen panels complaining of indigenous exclusion in psychedelic science? Check out our new pre-print: “Tū Wairua: Development of an Indigenous Rongoā Māori Approach to Healing with Psilocybin Containing Mushrooms” osf.io/preprints/ps...

Keen to read but important to note his name was Albert, not Alfred, Hofmann...

After several years absence from social media I have returned. Perhaps only temporarily. We will see.