Brilliant paper by Visscher et al. Populations differ in traits/disease burden. Are these differences due to genetics? Comparing single variants or polygenic scores between populations is biased due to environmental confounders correlated with the variants. 1/3 www.medrxiv.org/content/10.1...

A few thoughts on Herasight, the new embryo selection company. First, their whitepaper (drive.google.com/file/d/1EpFi...) implies that competitors like Nucleus have been marketing and selling grossly erroneous risk estimates. This is shocking if true! 🧵

What's going on in psychiatric genetics? The @pgcgenetics.bsky.social have now published our latest progress review in @thelancetpsych.bsky.social, highlighting discovery, and laying out a map for moving forwards! www.thelancet.com/journals/lan...

You don’t need more ideas. You need a better question. A thread on clarity, chaos, & what a Nobel Prize winner, a mosquito net & a PhD meltdown taught me about writing (+ thinking) better. 🪨 Here’s my new Respect the Marble post: catherineeunicedevries.substack.com/p/you-dont-n... 🧵

Excited to share that the second paper from my PhD has just been published in @NatMentHealth!🧠🧵 We modelled depression symptom networks in >35k teenagers to derive their 'network temperature' and found evidence symptom stabilisation across adolescence... www.nature.com/articles/s44...

Dissertation by Dr Rachel Los not only includes acknowledgements, but also .. anti-acknowledgements. delta.tudelft.nl/en/article/a...

You've heard of DNA, but what about GNA? Very excited about this preprint with @jgthorp.bsky.social and others that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics as input. 1/2 www.medrxiv.org/content/10.1...

New large study (n ~ 6 million) in @JAMApsych tracking mental disorder trends in Denmark showing increases in mood disorders in recent birth cohorts tinyurl.com/c5nyfd8k

A fantastic week at #WCPG2024 in Singapore! Grateful to work and travel with many wonderful people 🔬🦀🇸🇬

The terrific @pgcgenetics.bsky.social Major Depressive Disorder Working Group in Singapore

Hello from Singapore #wcpg2024!🌏 I am presenting an update on the current results of the *Adolescent-Onset Depression GWAS* on Friday at 3pm in the symposium on Genomics and Life Course Data. Come and watch!

I’m presenting three different projects at these upcoming conferences over the next month! Looking forward to meeting fellow MH researchers 🌏 · World Congress of Psychiatric Genetics 🇸🇬 · International Congress of Neuropsychiatry 🇦🇺 · Society for Mental Health Research Conference 🇦🇺

🚨🌡️New pre-print on PsyArXiv! We conceptualise and investigate *network temperature* as a measure of longitudinal stability in depression symptom networks across adolescence. [Replication in 3 cohorts with >35k adolescents!] osf.io/preprints/ps...

Network Temperature as a Metric of Stability in Depression Symptoms Across Adolescence: http://osf.io/9zmge/

This is the recording of my June 2024 keynote at the DPK congress, entitled "Embracing complexity: studying mental health problems as systems, not syndromes". They made a nice recording & allowed me to share it. Thanks a ton, DPK organizers 🖤. 🧪 #stats #psychscisky www.youtube.com/watch?v=B1cR...

Missing data, longitudinal binary symptoms for multi-group Ising model estimation. HELP!!!! Impute? If so, how to pool estimates? Don't think it's right to avg. over networks? Use maximum likelihood estimator instead? 😵‍💫

I am delighted to announce my first first-author paper has just been published in @JAMAPsych! 🥳🧬📈 ‘Genetic Architectures of Adolescent Depression Trajectories in 2 Longitudinal Population Cohorts’. Link to paper: ja.ma/4bkGsPj and a 🧵 of our key findings below…

Great job students and faculty of the International Statistical Genetics Workshop 2024 in Boulder, what an amazing week it was, as always 🧬❤️🍻 Next year it's GWAS and sequence data analysis again, see you then: colorado.edu/ibg/workshop