We make molecules!
@wemakemolecules.bsky.social
📤 94
📥 120
📝 16
The Yeast Natural Products lab, we love fungi and chemistry.
Dr. Kevin Yin and the
@keaslinglab.bsky.social
team engineered polyketide synthases to produce designer polycyclopropanated fuels with improved freezing points and energy density
www.nature.com/articles/s41...
🚀🧬
#SyntheticBiology
#Biofuels
#MetabolicEngineering
#AviationFuel
loading . . .
Polyketide synthase-based controlled synthesis of polycyclopropanated fuel molecules - Nature Communications
To be practically useful, sustainable aviation fuels need a suitable energy density and freezing point. Here the authors explore an iterative polyketide synthase family, leading to engineered biosynth...
https://www.nature.com/articles/s41467-026-73172-3
about 2 months ago
0
0
0
reposted by
We make molecules!
Science X / Phys.org
2 months ago
Genetic analysis of Hypocreales fungi has uncovered thousands of previously unknown natural compounds, highlighting new possibilities for sustainable, eco-friendly crop protection.
doi.org/hb2vsw
loading . . .
Scientists unlock fungi's secret chemistry, offering a greener path to crop protection
Pesky pests can wreak havoc on plants by chewing leaves, boring into stems, and sucking sap from trees. Beyond the direct damage, they also spread harmful bacteria, viruses, and fungi that can infect and ultimately kill the crops.
https://phys.org/news/2026-05-scientists-fungi-secret-chemistry-greener.html?utm_source=bsky.app&utm_medium=social&utm_campaign=v2
0
5
3
Looking for new biopesticides? or active ingredients for pest control? Check out this research briefing on our recent paper on Hypocreales and their chemistry
www.nature.com/articles/s41...
loading . . .
Surveying hypocrealean fungi to identify biocontrol agents - Nature Chemical Biology
Hypocrealean fungi are the most important source of fungal and insect pest biocontrol agents. By integrating phylogenomics, metabolomics and synthetic biology, we surveyed the biosynthetic capabilitie...
https://www.nature.com/articles/s41589-026-02202-4
3 months ago
0
0
0
reposted by
We make molecules!
Nature Chemical Biology
3 months ago
Hypocrealean fungi form symbiotic relationships with plants while antagonizing pests. A survey of 5221 of their biosynthetic gene clusters reveals that ~80% encode unknown products, which could have potential for pest control
www.nature.com/articles/s41...
loading . . .
A biosynthetic survey of hypocrealean biocontrol fungi - Nature Chemical Biology
Crop losses from pests threaten global food security. Here, the authors survey the biosynthetic repertoire of hypocrealean fungi, identifying over 5,200 biosynthetic gene clusters, most encoding unkno...
https://www.nature.com/articles/s41589-026-02201-5?utm_source=bluesky&utm_medium=social&utm_campaign=nchembio
0
3
1
We lose up to 40% of crops to pests. Fungal-based crop protection can help. The challenge? We barely know the chemicals fungi use to protect plants. Check out our paper on their biosynthetic potential. Led by Dr Ana Calheiros de Carvalho of YNP Lab + BRIGHT Biofoundry
www.nature.com/articles/s41...
loading . . .
A biosynthetic survey of hypocrealean biocontrol fungi - Nature Chemical Biology
Crop losses from pests threaten global food security. Here, the authors survey the biosynthetic repertoire of hypocrealean fungi, identifying over 5,200 biosynthetic gene clusters, most encoding unkno...
https://www.nature.com/articles/s41589-026-02201-5
3 months ago
0
2
0
reposted by
We make molecules!
Natural Product Reports
4 months ago
🔓Take a look at this
#OpenAccess
Highlight article from Pablo Cruz-Morales & co.
@wemakemolecules.bsky.social
discussing synthetic biology for heterologous expression and engineering of fungal polyketide synthases
#secmet
#natprod
📍
@dtu.dk
loading . . .
Synthetic biology for heterologous expression and engineering of fungal polyketide synthases
Covering: up to 2025Polyketide synthases (PKSs) are essential enzymatic systems that produce a wide range of natural products. Their biosynthetic features offer significant opportunities to create a…
https://pubs.rsc.org/en/content/articlelanding/2026/np/d5np00020c
0
3
2
reposted by
We make molecules!
Nature Microbiology
11 months ago
Read the associated news and views: Microbial chocolatiers of fine flavour 🍫 by Pablo Cruz-Morales
www.nature.com/articles/s41...
add a skeleton here at some point
0
12
7
Climate change is stressing our forests, fungal allies may turn into pathogens. Are we ready for this? Don’t miss this call to action for new model organisms & functional studies in forest pathogens. By Anne Oostlander and col. at TU Braunschweig and FABI
nph.onlinelibrary.wiley.com/doi/full/10....
about 1 year ago
1
3
2
Our biosynthetic survey of biocontrol fungi is out now!
lnkd.in/dJbyis5f
Dr. Ana Calheiros de Carvalho combined analytical chemistry, post-genomics and Synbio to catalog and discover lots of natural products. Data release in the next few days: Check our preprint for details ⚗️ 🍄 🥰 🌽
over 1 year ago
1
1
1
Our PhD student Adrian Gadar López and the Black Yeast Natural Products team made fungal PKS Heterologous Expression easy! Check out the preprint.
www.researchsquare.com/article/rs-6...
#wemakemolecules
#blackyeast
#NNF_BRIGHT
loading . . .
Black yeasts are efficient heterologous hosts of a wide range of fungal polyketides
Fungal natural products, including polyketides, are a rich source of bioactive molecules. Their biosynthetic enzymes are encoded within biosynthetic gene clusters, which are often activated by specifi...
https://www.researchsquare.com/article/rs-6001933/v1
over 1 year ago
0
4
3
reposted by
We make molecules!
Thom Booth
over 1 year ago
getphylo is finally official! Build phylogenetic trees directly from genbank files - at breakneck speed! I'd like to thank everyone who provided feedback and encourage you to continue. Improving getphylo doesn't stop now the paper is out! 1/5 🧪
bmcbioinformatics.biomedcentral.com/articles/10....
loading . . .
getphylo: rapid and automatic generation of multi-locus phylogenetic trees - BMC Bioinformatics
Background The increasing amount of genomic data calls for tools that can create genome-scale phylogenies quickly and efficiently. Existing tools rely on large reference databases or require lengthy d...
https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-025-06035-1
2
28
13
reposted by
We make molecules!
Tilmann Weber
over 1 year ago
Have a look at our latest study on large-scale
#Streptomyces
BGC mining / pangenome analysis:
genomebiology.biomedcentral.com/articles/10....
add a skeleton here at some point
1
23
9
Feeding 9 billion people will take lots of creativity and the best scientists. Check how Dr. Loes van Dam is working on new fungal foods are DTU biosustain.
#DTU_BRIGHT
www.euronews.com/health/2025/...
loading . . .
Fungi oysters: Inside the Danish lab producing next alternative food
At a Technical University of Denmark lab, researchers are exploring the potential for fungi to be used as meat and seafood replacements.
https://www.euronews.com/health/2025/01/06/mushroom-mycelium-as-sustainable-protein-inside-europes-leading-alternative-protein-resear
over 1 year ago
0
2
3
reposted by
We make molecules!
Tilmann Weber
over 1 year ago
Are you working with
#streptomycetes
? Then you may be interested in trying our new
#StreptoCAD
platform: StreptoCAD is an open-source software toolbox automating genome engineering workflows in streptomycetes.
www.biorxiv.org/content/10.1...
loading . . .
StreptoCAD: An open-source software toolbox automating genome engineering workflows in streptomycetes
Streptomycetes hold immense potential for discovering novel bioactive molecules for applications in medicine or sustainable agriculture. However, high-throughput exploration is hampered by the current...
https://www.biorxiv.org/content/10.1101/2024.12.19.629370v1
1
19
15
Diplodia sapinea a pine endophyte lives a harmless life until the tree is dying... Climate change is stressing trees and turning harmless fungi into pathogens. How? It is not clear, new tools to study them are needed, check work by Anne Oostlander of TU Braunschweig
journals.plos.org/plosone/arti...
loading . . .
Development of a molecular genetics and cell biology toolbox for the filamentous fungus Diplodia sapinea
Diplodia sapinea (Fr.) Fuckel is a widespread fungal pathogen affecting conifers worldwide. Infections can lead to severe symptoms, such as shoot blight, canker, tree death, or blue stain in harvested...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0308794
over 1 year ago
0
3
1
The perfect molecule doesn't exist... Until Dr Ana Calheiros de Carvalho find it with her metabologenomics workflow for biocontrol molecules! Check it out poster #81
#NP2025
San Diego
#DTU_BRIGHT
over 1 year ago
1
6
1
N.R.P.S. will stand for No Resistant Pest will Stand after Dr Carolina Cano-Prieto engineer them with her SynBio tools. Poster 38
#NP2025
#DTU_BRIGHT
#sustainableagriculture
over 1 year ago
0
5
1
Saccharomyces Fans are scared of this black yeast! Check out how our PhD student Adrian Gadar-Lopez and his black yeast makes bioproducts like gangbusters. Poster #37
#NP2025
#DTU_BRIGHT
#clickbait
over 1 year ago
0
8
3
Do you dream of making polyketides advanced materials with polyketide synthases? Check our PhD student Sidharth Jayachandran's poster at
#NP2025
San Diego
#OMG
#DTU_BRIGHT
over 1 year ago
0
9
1
reposted by
We make molecules!
Kai Blin
over 1 year ago
The
#antiSMASH
beta is now live on the website. There’s some minor updates and maybe a bug fix out two separating us from what will be in the final release. Please let up know if you run into any bugs. Thanks to all the contributors for getting us past 100 detection rules and all the other updates
1
13
5
reposted by
We make molecules!
bioRxiv Synthetic Biology
over 1 year ago
StreptoCAD: An open-source software toolbox automating genome engineering workflows in streptomycetes
https://www.biorxiv.org/content/10.1101/2024.12.19.629370v1
0
1
2
reposted by
We make molecules!
Tilmann Weber
over 1 year ago
This time a little different story from our lab
@dtu.dk
: here we present
#ActinoMation
, a literate programming workflow to automate
#Streptomyces
conjugation on Opentron robots.
www.biorxiv.org/content/10.1...
loading . . .
ActinoMation: a literate programming approach for medium-throughput robotic conjugation of Streptomyces spp.
The genus Streptomyces are valuable producers of antibiotics and other pharmaceutically important bioactive compounds. Advances in molecular engineering tools, such as CRISPR, has provided some access...
https://www.biorxiv.org/content/10.1101/2024.12.05.622625v1
1
12
5
Check out this fantastic work on how Drosophila comensal bacteria evolved host-specific adhesins to hang to their gut. by Dr. Karina GUTierrez. Of Carnegie @karinagtzga by the power of functional genomics and live imaging!
www.science.org/doi/10.1126/...
#f
loading . . .
A conserved bacterial genetic basis for commensal-host specificity
Animals selectively acquire specific symbiotic gut bacteria from their environments that aid host fitness. To colonize, a symbiont must locate its niche and sustain growth within the gut. Adhesins are...
https://www.science.org/doi/10.1126/science.adp7748
over 1 year ago
0
1
0
Today was a great day at YNP, DTU biosustain. we hosted a seminar by Dr. Manu Villalobos our winter guest. He showed us his systems biology tools for filamentous fungi and speed the Trichoderma gospel!
#fungi
#biocontrol
#sustainabity
over 1 year ago
0
7
1
you reached the end!!
feeds!
log in
