Pleased to have been awarded the ETH Medal this summer for my PhD thesis! Many thanks to all those who supported me through my journey, especially my PhD supervisor Prof. Bill Morandi.

Congrats to @fruepp.bsky.social, Vasily Grebennikov, Mykola Avramenko, Marc-Olivier Ebert "Kinetic, Spectroscopic, and Computational Investigation of Oxidative Aminative Alkene Cleavage Reveals an N-Iodonium-Iminoiodinane Pathway" now @chemrxiv.org - chemrxiv.org/engage/chemr...

We have two open PhD positions to start our new group at University of Geneva! If you are interested in organometallic chemistry, heterometallic complexes and mechanistic investigations, please contact me. Check more details here: jobs.unige.ch/www/wd_porta...

Blunt letter to the editor on ACS: "If ACS won’t stand up now, it should stand down." cen.acs.org/business/Rea... #chemsky 🧪⚗️

100 %. Very frustrating that EU institutions increase funding when they eye US researchers, but don't care about scientists in Europe who leave science for other careers in droves. Why endorse American exceptionalism? That is to say nothing of the intra EU inequality, a whole other can of worms.

Re-upping this post this morning: Big Pharma CEOs are finally starting to speak out about the Trump administration. Unfortunately, they’re smiling and clapping.

Biopharma companies and CEOs are keeping their heads down at their own peril. They should speak up about what’s happening to the NIH and other science agencies before it’s too late. Silence gives consent. And no one should consent to this.

When the federal government abandons important areas of funding and leaves a gaping hole in the advancement of science, any prudent funder would fill the hole, not follow suit. I don’t know the rationale here but seriously WTF? Disclosure: HHMI paid my way through graduate school.

Hey American PIs. If you have undergrad students who, for whatever personal reasons might find it...appropriate to not do grad school in the good ol' US of A for the next 4+ years, I (and my colleagues at UWindsor Chem) are open to applicants. They pay Canadian domestic rates at UWindsor.

And you WON'T BELIEVE the incentives the Canadian Government will give you to just do R&D in Canada. It's literally insane. Anyways, happy to talk and connect people if anyone is interested. Things might get rocky for a bit, and staff might be happier living somewhere that thinks they are humans.

How does one include all sources of error for a quantity of interest obtained by fitting a model e.g. rate constants from kinetics? Simulations give the answer: atigdnc.netlify.app/post/error_handling/ tldr; fit each dataset, propagate and combine errors (or random effects model). #chemsky

Wrapping up 2024 - quite the year! I defended my PhD, after more than 4 years at ETH. Here's hoping 2025 has something just as exciting in store!

Along similar lines, the results of the second protein binder design competition were announced and de novo design didn't do so well: www.adaptyvbio.com/blog/po103

I think that just like with protein prediction, the community should now only look at the results of competitions (à la CASP). The docking equivalent is: cache-challenge.org www.nature.com/articles/s41...

New radical cross-coupling using phosphonium salts and HMDS anion as the electron donor: www.nature.com/articles/s41... I watched Sven lead this work experimentally and computationally and was very impressed - very rare for someone to be so adept at both. Great to see his hard work pay off.

For trans day of remembrance, this is Ben Barres. Ben was a remarkable biologist who transformed our understanding of brain function. Born in 1954, he transitioned from female to male in the late 1990s.

My first FA of my PhD investigated the factors controlling the β-Η/β-Χ competition in Pd(II) alkyls: rdcu.be/cVqUz The eagle-eyed will notice that we did not address the relative metal electronics at T-shaped vs. square-planar Pd(II) (minor spoilers for upcoming research). #chemsky

An amazing thing to say. Whoever it was has a greatly inflated idea of what the Big Labs are able to think of and to cover.

A tool for predicting glycosylation based on structure: www.nature.com/articles/s41... Hopefully this is broadly generalizable, it would be invaluable.

Has anyone ever collected solution state NMR spectra on a protein immobilized on beads? #NMRchat

📯📯 Chemical Biology starter pack 📯📯 140 PIs & groups posting primary research in chemical biology. Please reskeet (?) & reply to this post if you want to be added! go.bsky.app/KLrTWoj Let's make ChemBioSky even greater again! #realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange

Joining #chemsky, I'll revisit some previous research, while I wait for review on the latest. In 2023, we reported scXRD of N-O OA of Ni(0) to isoxazoles (acs.organomet.2c00533), illustrating a long-proposed mode of catalyst poisoning. Contrary to the literature, we did not observe this for Pd(0).

Definitely a must read Amazing work from the @HartwigGroup out in @J_A_C_S Air stable Ir precat for C-H borylation with large scope and 1-pot Borylation-Suzuki, bromination or Chan-Lam Super paper and will be of high use in med chem #ChemSky