I havent read such a banger of an essay in a very long time. This is so well-written!

IF this can scale (and have ridiculously efficient turnover), then...maybe? But scientifically, this is incredible.

A PhD is not about accomplishing "a research." It is about learning how to solve problems that you have never seen before. Turning to Bullshit Machines for this (except in big data analysis) is the opposite of the skillset a PhD is all about. Thank you for coming to my TED talk.

This is a really disingenuous headline @economist.com. I used to read you all the time as a rock solid middle of the road NEWS magazine (early 2000s). But it's become reactionary slop. Poorly funded universal childcare is bad. Well funded is good. Higher taxes, better funding, and it is AMAZING.

I would put more money on continuing to harvest infinite energy from the sun over assuming that forcing everyone to use The Machine The Lies To You is the steady basis of an entire economy

I have seen many ambitious and non feasible things in my life. I've written some of them. This is pretty high on the list. 10^84 ish t cell receptor possibilities. Good luck with that. The immune system is hard. Really hard. The only sufficiently complex model is an immune system.

We’re relaunching The Matter Blotter — our Substack newsletter where the Matter Lab members will be writing about their research in greater detail, going beyond what’s possible on social media (and way past the Bluesky character limit!). Subscribe here: aspuru.substack.com

If #Budget2025 is supposed to be one that is "generational," it is a shame that investing in those who are already here and contributing to Canada's future have been completely overlooked. /fin

Nice to know Fascism remains popular with only about 40% of the electorate in the USA. I can sleep easy for the next few years on that basis. Rather shocked that the elections were held fairly though. Was sure there were going to be shenanigans.

It is exhausting realizing that the best way to get solid, stable funding in Canada as an academic would be to leave, and then come back. Because apparently, we have no talent in this country, and we need to go out and get it. We have oodles of talent. It's tiring.

Yup. AI is useless if the data is useless. Here's the secret: the data is useless. Storytime (short one. I'm sick).

Who else is excited about a new Matthew Good EP? Anyone? Anyone? k.

Academics in Assyria in the 7th c BC complain that admin is preventing them from doing research and teaching

I love Baseball. I have a large collection of cards, '88-92 or so. Lots of moustaches, lots of different physiques. All sports used to be like that. But baseball still is. These guys all look like they came straight out of 1985. And Kirk, being a world-class catcher shows my physique is elite.

Canadian researchers should be aware the there is a motion before the Parliamentary Standing Committee on Science and Research to force Tricouncils to hand over disaggregated peer review data on all applications: Applicant names, profiles, demographics Reviewers names, profiles, comments, and scores

At this critical moment Canada is making poor decisions when it comes to funding for science and higher education. Austerity in this sector at this point in time will decimate the knowledge economy in all of North America. Funding a couple of high profile chairs is not going to solve the problem.

My 3.5 year old daughter who loves playing with balls is wearing pants made for 6 year olds. We are now opening the bidding for her NCAA basketball school. It starts at 2.7 million and a cookie. Chocolate chip.

Adobe's AI's brilliant synopsis of: "Mechanism of the Schiff Base Forming Fructose-1,6-bisphosphate Aldolase: Structural Analysis of Reaction Intermediates" (It's a banger) is...

When people learn with ChatGPT instead of following their own searches, they end up knowing less, caring less, and producing worse advice, even when the facts are the same. Friction is an essential ingredient for learning! Convenience makes us shallow. academic.oup.com/pnasnexus/ar...

So, want to shout out one of the best undergrads to EVER come through my team (we've had about 200 now and some are STUPID good who are going to blow me away. Good. They deserve to.) But this one WILL be much better than me. Teagan Kukhta...you heard it here first doi.org/10.1021/acs....

For those who like this work: There are still 2 weeks left to apply for the PhD position in my group! www.chemzymes.com

5, and its probably going to stay that way for a long while now.

I stand with Alberta teachers

I like the "ladies who dig science" implied below. Or rather not implied below, but clearly should be.

Maple is a spring flavour if it has a season at all, you Philistines. Next you are going to be talking about cappuccinos after dinner aren't you?

That's no MALDI! That's a SPACE STATION! cue Imperial March. But, really, its a really cool paper.

AI Industry: AI IS GOING TO TAKE OVER THE WORLD! AI: "This document outlines a copyright transfer agreement between the American Chemical Society and the American Chemical Society. The agreement ensures fair and non-confidential research submission and allows for adaptation to new technologies."

I'm not on any "side". I just spin from one side to the other and am generally in favour of mixing it up

Writing a paper. Had this as an endnote, but, moved it to a footnote to make sure I leave it in on purpose: "The degree of the [scientific] tragedy can be measured by the duration of loud wailing or quiet sobbing starting when the student learned that a synthesis failed.

Renowned cryptologist Robert Langdon waited by his phone. Surely, the French authorities would call him, a renowned cryptologist, to solve this mystery he thought in italics.

The incredible @shufflersunite.bsky.social and i are rather accomplished academics. But, tonight, instead of being asked to cure cancer or understand the human experience we were tasked with something truly hard. "Want to draw a monster?" Id love to say these were the baby's efforts.

I am looking for a PhD student interested in enzymes! For the full annoucement: www.chemzymes.com

Steve Withers demonstrating once again how fundamental science leads to breakthroughs that can change lives. #chemsky

Won't somebody think of the poor billionaires??

Removing t1 noise from homonuclear 2D NMR data - video tutorial. youtu.be/XhmzjxkPouo?... #nmr #nmrchat #chemsky

Happy Real Thanksgiving everyone!

This is a hockey skeet. Bleat? You win some, you shit-the-bed-some. #GoSensGo

Sensfans, the Sens Signal has been lit. A citizen calls upon us, not to remember Some Guys, but to discuss the very essence of hockey Guyness. Like one of Plato’s dialogues, together, we can find the ideal!

As Anna notes...I don't think people who write newspaper articles actually understand what thinking is. The prize is for the IDEA that was executed right. The science needed to be done, but that was done by 100s of people. Much more deserving than the instruments they used.

This is huge: “A drug that provides near-perfect protection against H.I.V. with shots just twice a year will be made available at $40 per patient annually in low- and middle-income countries, offering new hope… making lenacapavir a realistic choice in countries with constrained resources.”

I'm at that point in a big grant where I can see the end and I'm happy with what I've written. Actually excited to spend the day (morning) writing...of course my inner voice tells me the excitement will abate but I'm enjoying it for now!

H5N1 is a huge threat. An H5N1 pandemic would make COVID look like a walk in the park. It keeps me up at night. H5N1 is a much more dangerous virus than SARS2. It will wreck agriculture as well as killing people. A deadlier pandemic, w/ added starvation & ecological devastation.

No, but due to delayed maintenance and zealous fanatical lowest-bidderism-damn-the-quality, our entire campus is antediluvian as biblical floods are inevitable inside the buildings if we get a light rain.

#GoSensGo.

Asking Nick Clegg for permission to take all his money out of his bank account would kill my "Take all Nick Clegg's money out of his bank account" business. Look, I'm willing to diversify to "Take all billionaires money and transfer it as block grants to developing nations."

As a well established MOF-hater...congrats to the laureates. It's well deserved. And certainly chemistry for those in the cheap seats. I'll go back to hating MOFs tomorrow (nothing against em, I just hate trendiness in science and think it harmful).

The baby, accomplishing absolutely nothing except frustrating all of us: "I did it! Great Job!" Any university need a good VP of...well...anything? On top of the $300k salary, her expense account is mostly goldfish crackers and cookies, and she won't actually make anything worse.

We need to remind ourselves of the small victories. If you have successfully used a toilet today, Good Job!

Technically, I think one needs to be cautious about company logos in pictures entered into the scientific literature. But, sometimes something sneaks through on a coffee mug. pubs.acs.org/doi/10.1021/... #GoSensGo