Call for contributions/demos for programming 2026 in Munich, March. Ooh I'll have some serious shit cooking by then. 2026.programming-conference.org/home/substra...

Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.

New blog post: "Explorable explorable explanations" Building on Bret Victor's concept of "explorable explanations" for scientific publishing. blog.khinsen.net/posts/2025/1... 🧪 #MetaSci

AI hype letter remains open for more signatures tinyurl.com/Sign-Letter-...

Scientists and scholars in AI and its social impacts call on von der Leyen to retract #AIHype statement. @olivia.science @abeba.bsky.social @irisvanrooij.bsky.social @alexhanna.bsky.social @rocher.lc @danmcquillan.bsky.social @robin.berjon.com & many others have signed www.iccl.ie/press-releas...

Played with @khinsen.net's hypedoc today. Wow, really good. @tomasp.net u would like. ALT + CLICK on most elements to reveal the source code, all the source code elements are hyperlinked. So deep for exploration. hyperdoc.khinsen.net/94FE4-microg...

Had a fun meeting with @ronentk.me and we set a simple landing page for @atproto.science 🧪 Take a look at atproto.science

Finally transferring my mastodon book thread on Hasok Chang's Is Water H2O? Evidence, Realism and Pluralism over here. My notes are somewhat haphazard, just remarking on things I found interesting at first read. And the thread appears to end abruptly. Been a while; can't remember why.

Totally agree – we need peer review for research software. At least the “artisanal” stuff – those small, medium-size scripts, notebooks, workflows that drive much science. Reviewing them would make results clearer, more reliable, and way more trustworthy. #science #openscience #opensource

This is not an exaggeration. Everything — *everything* — is downstream of energy. Our technological prowess is downstream of the massive power subsidies we have been getting from fossil fuels.

«The input does not cause the output in an authorial sense, much like input to a library search engine does not cause relevant articles and books to be written (Guest, 2025). The respective authors wrote those, not the search query!» via @olivia.science via#2 @irisvanrooij.bsky.social - thank you

New publication: "Reviewing research software" Unlike experimental or theoretical methods, software is almost never peer reviewed. Maybe this should change. But is it possible at all? doi.org/10.1109/MCSE... Preprint: hal.science/hal-05274018 🧪 #openscience #metascience

We are thrilled to announce that our NEW Large Language Model will be released on 11.18.25.

I'm at #uist2025 presenting our new work with @jonathoda.bsky.social! 𝗗𝗲𝗻𝗶𝗰𝗲𝗸 is a computational substrate for end-user programming that makes it easy to implement programming experiences like programming by demonstration, collaborative editing and more! tomasp.net/academic/pap...

Question to Linux experts: Where does this weird pop-up come from that I get whenever pressing a deadkey on my keyboard? How can I disable it? I see this since I updated from Debian 12 to Debian 13. I see it only in a few programs, such as xterm and Emacs, where it often covers text I need to see.

In the early days of quantum chemistry, before we had computers to calculate the shapes of electron orbitals, one man invented a mechanical machine that simulated their shapes. My latest column for @chemistryworld.com www.chemistryworld.com/opinion/the-...

One thing that fascists understand well is that social and traditional media are both media and need to be controlled to undermine democracy. Meanwhile, in camp democracy no government seems to fathom this simple fact let alone act in consequence. We need more strategy less meekness.

"Epistemic oligarchies: capture and concentration through science reform", a new preprint by Sven Ulpts (not here), Sheena Bartscherer (also not here), @nicolecnelson.bsky.social and me. Read it here: zenodo.org/records/1713... 1/

LINK ROT: 38% webpages that existed in 2013 were no longer available 10 years later. Even among pages that existed in 2021, 22% no longer accessible just two years later. This is often because individual page was deleted or removed on otherwise functional website. Many implications for knowledge 🧪

Slides from my talk "Critical Architecture/Software Theory" at PPIG 2025 in Belgrade: tpetricek.github.io/Talks/2025/c... The talk has been a great excuse to organize some more ideas, on top of my earlier article on the topic: tomasp.net/architecture/

I'm still a bit shocked at the attention because I expected something, but this is immense. 11k views on zenodo!? What? Thank you all! (doi.org/10.5281/zeno...) Wondering if my new followers are into my research? Shall I do a thread of my work for you all? Do you like papers also like below? 🥰

Very cool postdoc opportunity (at intersection of physics, philosophy, and complex systems) ⬇️

Good scenario planning doesn’t predict. It… - Models systemic forces - Explores how they may collide to generate a wide range possibilities - Prepares multiple contingency plans Adaptation beats prediction in VUCA environments.

"The central axis of this geopolitical struggle will not be the 20th century’s struggle between liberalism and authoritarianism, but a clash over the metabolic basis of modern industrial society." foreignpolicy.com/2025/09/01/e... I think this piece is worth your time but I have quibbles & notes. 🧵

Our data stewards have started recommending that we no longer use US-based infrastructure for #openscience practices, given the risk of (near-future) censorship, from pre-print and data hosting to preregistration and more. That includes OSF.

At the last NGI Forum, when asked what I would like to have next to address the threats of tech authoritarianism, I answered that the first thing I wanted was a European Commissioner in charge of Tech Sovereignty. Was this too harsh? 🧵

Ah, so I discover on returning from holiday that @thenewworldmag.bsky.social has also published my piece on the current assault on truth. I intended it as a kind of taxonomy, to help make sense of the onslaught. www.thenewworld.co.uk/phillip-trum...

This is sort of part two to the far more enjoyable (to write and, hopefully, to read) essay "how to science a science with science". You might want to read that first. diagrammonkey.wordpress.com/2025/07/03/h...

Metathugs Science, metascience, metametascience, *critical* metascience, and how science's greatest strengths are its greatest weaknesses. Gloomier than usual and it's only Wednesday. diagrammonkey.wordpress.com/2025/08/13/m...

Metascience 2025 recordings are now available! #Metascience25 gathered researchers, funders, policymakers & more to explore how the research process can improve. The program included preconference symposia & plenary sessions on topics from policy change to AI in research. 🎥 cassyni.com/s/metasc...

@khinsen have you seen this survey on computational reproducibility in HPC: https://ec.europa.eu/eusurvey/runner/computationalReproducibility2025 Thought you might be interested if you hadn't seen it yet.

It’s Open Access!! If not available today, it should be by tomorrow - definitely don’t pay that money 😊

Just out /2: condensing years of thinking, my philosophical examination of “Environmental Intelligence” as framing for foundations of #AI is on @harvarddataverse.bsky.social ! Officially published with commentaries in October, but sneak preview here: hdsr.mitpress.mit.edu/pub/mx9vpa0b... #philsci 🧪

Just out / 1: “methods in philosophy of science”, #OA heroically assembled by Adrian Currie & Sophie Veigl. Comments welcome on mine & @Rachel Ankeny’s “Research design for philosophy of science in practice”, topic close to our hearts & constant source of questions! mitpress.mit.edu/978026255224...

Possible scenario: Step 1: AI arms race triggers massive buildout of solar and nuclear. Step 2: Architecture breakthrough reduces data and energy requirements by orders of magnitude. Step 3: clean energy transition accomplished.

Just listened to this episode. 🧪 Fascinating, impressive... and scary. "Novel entities" is one of the already transgressed planetary boundaries. Lee Cronin proposes to make it a lot easier to design and produce even more novel entities. With venture capital funding. What could possibly go wrong?

🆕 From now on, MetaROR can also include author responses on its submission pages. You will find them underneath the assessment & reviews. Have you already been reviewed on MetaROR & want to provide a response? Please contact your editor. 👇 Two of our submissions now include such a response [1/3]

“The saddest aspect of life right now is that science gathers knowledge faster than society gathers wisdom.” What is the role of human researchers in the age of AI? Great synthesis here, with many thought-provoking ideas that deserve broader discussion. Thoughts🧵 > cadmusjournal.org/article/volu...

I get this, but I'm not sure about the framing. Children around the globe are increasingly at risk because *we are warming the planet to insane levels*. THAT'S the problem here.

This essay by Nisheeth Vishnoi is a thoughtful meditation on the nature of science and a rebuttal to the notion that AI systems are going replace human scientists anytime soon. Worth reading. nisheethvishnoi.substack.com/p/what-count...

Why I'm more optimistic than others about metascience (or metaresearch) (I wanted to write up some thoughts on #metascience2025 but I just don't have the time so this thread will have to do.)

unix pipes still kinda feel like they’re from the future which is embarrassing because it suggests our programming paradigms are still stuck in the distant past

I got tired of the nonsense some AI leaders were coming out with, and so I wrote this for @newscientist.com www.newscientist.com/article/mg26...

I was interviewed by the journalist Jessica Nordell for her newsletter. We discussed some deep questions related to AI touching on humanities, politics, & dualistic assumptions underlying the conception of "intelligence" in AI. I hope you will read it! jessicanordell.substack.com/cp/166912581

It’s odd to see a discipline so firmly tethered to a pair of claims that any other perspective, question, or evaluation of the claims becomes a heretical side show. I briefly considered going to Metascience but lost interest when it seemed anyone’s work who didn’t endorse these claims is “critical”

New blog post: "Explaining software and computational methods" blog.khinsen.net/posts/2025/0... 🧪

It's interesting to watch just how fast Apple is enshittifying. Mobile OSs is a problem we need to solve because choosing between two shitty experiences from incompetent, uncaring oligarchies isn't long-term viable.

We really don't know what software we're running any more. Nor what hardware, to be honest.