whaaaaat how unexpected!

This analysis remains undefeated.

hi science bluesky 🧪 i have a question. has anyone shown if sgRNAs are susceptible to degradation by RNases when they're bound to the Cas9 protein? I know they're very unstable when unbound, but I can't seem to find evidence of their stability in the RNP complex. any help is appreciated!!

Hey remember when the CDC dropped 6 of the 8 foodborne illnesses from the nationwide monitoring system in July and one of them was listeria? Mentioning for no particular reason www.nbcnews.com/health/healt...

An unprecedented violation of our civic and Constitutional traditions. Calling every military leader in the world back to the U.S. to hear a wildly inappropriate partisan campaign speech followed by a fascist call to use the military against Americans.

This is the official communication from the FDA to physicians on acetaminophen use in pregnancy. - They acknowledge the lack of a causal link with autism - Essentially tell physicians to keep doing what we've been doing anyway It's very different from the press conference. Pass it on.

Reminder: a large (2.5M+) sibling control study found "no evidence of increased risk of autism, ADHD, or intellectual disability associated with acetaminophen use". Precisely the kind of data that requires serious consideration before declaring mission accomplished. jamanetwork.com/journals/jam...

made this

Universities. Rural hospitals. Tech companies. Several sectors are going to be profoundly hurt by this. Not to mention the chaos of the moment as current H1-B owners scramble to get back to the U.S., cancel travel, etc. due to the uncertainty. An absolute mess. As intended.

the epistemic breakdown of factual reality in this political media environment has been so harmful when facts genuinely favor the left, the right will simply deny the facts or call the messenger biased, without any refutation reality will always be biased against a movement detached from reality

We're witnessing the most aggressive, fanatical crackdown on free speech in my lifetime. The speed and breadth of government censorship and private sector and nonprofit capitulation has been astonishing. As has the lack of urgency/silence from people who've long claimed to care about this stuff.

Political violence is abhorrent. I have not celebrated Kirk's death. But Newsom calling for his followers to "continue Charlie Kirk's work," someone who praised stoning gay people as "god's perfect law," who called for men to "take care of" trans people like they did in the 50s and 60s, is not it.

Glenn Beck’s media outlet The Blaze just gave an interview last month to the person who killed the politicians in Minnesota

political violence is a terrible scourge that has claimed victims from both parties the way some people are just itching to treat this as a reichstag fire moment to enable a dictatorship is extremely scary and a good reminder that political violence is a threat to the very core of liberal democracy

Hot off the press: We can provide for the first time a systematic attribution of recent #heatwaves to the emissions of #carbon_majors. Essential new #Nature article coordinated by @yannquilcaille.bsky.social at @ethz.ch, with numerous contributors @usyseth.bsky.social: www.nature.com/articles/s41...

Here is a word cloud of the words that were missing from the noncompetitive renewal awards but had been present in the parent award. 3/4

i remember seeing this chart in high school as a fun lesson"both sides are extreme, trust the center" and looking back now i grow weary

one of the great conservative moves over the past decade has been to make themselves so unpleasant that their own family members are forced to cut them off, and then use that fact to argue that *liberals* are too uncivil

if you'd rather save face than run a successful country, you're not cut out for politics

I will remind folks those images of Nazi book burnings aren't burning just any books. They're burning the library of Magnus Hirschfeld; a gay, Jewish doctor who created an institute dedicated to LGBTQ sex education and healthcare. And a man who pioneered gender affirming care surgeries.

i don't think gavin newsom is our only choice in resisting fascism. he's just the one making the biggest spectacle of gesturing in that direction

Excited to share our pre-print examining microbial activity and carbon utilization in the serpentinizing subsurface! Tl;dr: Serpentinite-hosted microbes are notably active, thriving on DIC despite alkalinity. Implications for #astrobiology, #carboncapture, and #GeoH2! www.biorxiv.org/content/10.1...

Japan Post just announced they will no longer deliver mail to the United States, joining Germany, Austria, Denmark, Italy, France, and Sweden.

She was never apolitical, she just took aim at fat people, which people thought was acceptable and therefore they misinterpreted her as apolitical.

At the first Nazi-run faculty meeting at the first university they took over (the nation’s most liberal and most illustrious), everyone expected the most liberal professor to stand up. But just asked the Nazi position on funding in his area.

refusing to accept this isn’t just about “purity” or whatever, it’s about effective politics. someone who thinks it’s practical to cave on trans rights misunderstands how politics works, they don’t recognize that public opinion is forged by perseverance

Today, I would like to honor the memory of Roger Y. Tsien, who died on August 24, 2016. His legacy lives with all who use his technologies, including calcium sensors, fluorescent proteins, the acetoxymethyl (AM) ester, & many more! #FluorescenceFriday www.nature.com/articles/nme...

Deeply divided Supreme Court lets NIH grant terminations continue arstechnica.com/science/2025...

Nature: Cancelling mRNA studies is the highest irresponsibility go.nature.com/3HDx4wD cc Jay Bhattacharya

this is the job openings page for ICE

Several people have suggested that I compile my emails to Bhattacharya and I am delighted to do so. Announcing the first cut of "Fifty Shades of 'Jay' jeremymberg.github.io/jeremyberg.g... This contains just the first few exchanges. I will be adding more as time permits.

White supremacist tropes and ironic viral jokes illustrate the administration's project of redefining who belongs in the United States.

As folks are watching Fit For TV, the documentary about The Biggest Loser, a few reflection questions: How did The Biggest Loser teach you to think about people who are fatter than you? How did it teach you to treat them? Where have you unlearned those lessons? Where can you do more unlearning?

Newsom has backstabbed trans people and homeless people repeatedly, but you’re fine with that because you’re not affected. People like you demand one-way coalitions. Morally and strategically bankrupt.

Music to my ears. This is brilliant. Either 90% of us can claim to be better musicians than Beethoven or… maybe just maybe polygenic scores aren’t perfect?

this is just straight-up dictatorship and it’s repulsive and pathetic our newspapers and TV stations still won’t say so. there is no emergency. there is no precedent for this in US history. Trump is establishing military and paramilitary control of the capital

made these

"Kennedy conveniently neglects to mention that he and nearly everyone he chose for leadership roles at HHS were responsible for the erosion of trust." He must go.

One of the destabilizing things about this moment is how clear it is that the folks who are actively destroying democracy and public health while openly celebrating racist/fascist ideologies and embodying truly debased values seem to have absolutely no fear of any future reckoning.

new post on my newsletter sellish.ghost.io/glazing-and-...

1. "'Trusting the experts is not a feature of either a science or democracy," Kennedy said." It's literally a vital feature of both science and of representative democracy. I've written a fair bit about trust in expertise as a vital mechanism in the collective epistemology of science.

Phang: The Constitution says representatives shall be determined by adding to the whole number of free persons. It doesn’t say you’re only supposed to count U.S. citizens. Trump says you’ve got to redo the census but can’t include “illegals”? Tough shit—the Constitution says otherwise.

I spent this morning talking to the CDC shooting suspect's neighbors. They said he was polite, helpful and OBSESSED with vaccine conspiracy theories. www.nytimes.com/2025/08/09/u...

Man Who Thought He'd Lost All Hope Loses Last Additional Bit Of Hope He Didn't Even Know He Still Had theonion.com/man-who...

This is literally some of the craziest shit I have ever read. And that's saying a lot. www.whitehouse.gov/presidential...

broke: AI for determining the species of birds based on their calls woke: beep learning model

anyone else?

biotech tradeschool when

A study in Nature Human Behaviour finds that four-day work weeks without a reduction in income boost workers’ job satisfaction and physical and mental health, driven by enhanced work performance, lower levels of fatigue and fewer sleep problems. go.nature.com/3Um75MP #econsky 🧪