One of Constable’s “six-footers” that earned him first prize at the Paris Salon in 1824.

'Visuals expose batch effects, hidden subpopulations, nonlinear behaviors, and experimental artifacts that often remain invisible to summary statistics alone. These insights directly shape which data can be trusted, which controls are needed, and which experiments should come next.'

Now on the GREAT SCIENCE SHARE: Reaching thousands of primary schools across the UK and far beyond talking about the importance of the fruit fly #Drosophila youtu.be/7Q1cOtzMcqk?...

Introducing The Structural History of Eukarya (SHE): The first proteome-scale phylogeny constructed entirely from 3D structure. We computed 300 trillion alignments across 1,542 species to map the tree of life. 🧵👇 (1/5)

Yesterday we came together to honour Professor Raymond Dwek through the naming of the Raymond Dwek Seminar Room. Raymond's family (pictured) joined the celebration and Raymond was visibly touched, saying: "Thank you for this amazing gesture. I'm humbled by it, but I will treasure it."

This is the stranger’s case, And this your mountainish inhumanity

Just discovered the wonderful covers of 'Genes to Cells', the journal of the Molecular Biology Society of Japan @mbsj-official.bsky.social – absolutely beautiful! here some examples inspired by mitosis, CRISPR, the DNA helix, and plant pigments

'to treat peer review as a throughput problem is to misunderstand what is at stake. Review is not simply a production stage in the research pipeline; it is one of the few remaining spaces where the scientific community talks to itself.' 1/3

👇Word

Grief stood like a sentinel in public. On the steps of the Public Theater, Peter Dinklage read Amanda Gorman's poem, "For Renee Nicole Good." No spectacle. Just a voice carrying loss out loud. Renee should be here. Saying her name matters. Remembrance is resistance.

Beautiful

Δυο κεφάλαια από αυτά τα βιβλία (11 και 14) μιλάνε για έλεγχο των ασθενειών όταν προκύπτουν. Δεν υπάρχει καμία ένδειξη ότι το εμβόλιο μεταδίδεται ως εξασθενημένος ιός ή ότι είναι υπόστρωμα για ανασυνδυασμό. Εννοείται ότι δεν φτάνει ο εμβολιασμός-πρέπει να γίνει και lockdown αλλά όχι θανατώσεις.

New paper from the lab published in Development. Where we discover that an innate immune pathway (Toll/NF-κB) is necessary and sufficient to promote intestinal stem cell mitosis while blocking diffetentiation. journals.biologists.com/dev/article-... @biologists.bsky.social

I’m thrilled to share our work on phage triggers of the bacterial immune system in its final form @natmicrobiol.nature.com www.nature.com/articles/s41...

How does ageing influence the way our bodies handle infection? go.nature.com/4sMZuqW

Beautiful write up for a beautiful, heavy, “out-there” record: King Crimson in the 80s pitchfork.com/reviews/albu...

Είναι απίστευτο. Ο τύπος δεν επιχειρεί να απαντήσει καν στο ερώτημα, αλλά αναμασά διάφορες βλακείες. Να το πούμε άλλη μια φορά: σε τοπικά ξεσπάσματα (local outbreaks) μολυσματικών ασθενειών (ζώων, ανθρώπων δεν έχει σημασία) ο εμβολιασμός είναι *τυφλοσούρτης*.

Δείτε την απάντηση του Μαρινάκη στη σχετική ερώτηση του @chris-avramidis.electricrequiem.com.ap.brid.gy.

This just in from Elena Urioste and Tom Poster 📣 Samuel Coleridge-Taylor's Ballade in C minor features in their Sunday morning concert this weekend, alongside works by Elgar, Schoenfield and Still 🎻 Tickets include a complimentary coffee, sherry or juice ☕️🍷🧃

Sci-fi author Kim Stanley Robinson, whose book inspired our special issue this week, talks about how the limits of human tolerance for extreme weather spurred him to write. Listen to the full interview on our podcast www.youtube.com/watch?v=2xCt... Or read ⬇️ www.bmj.com/content/392/...

With some trepidation, I'm putting this out into the world: gershmanlab.com/textbook.html It's a textbook called Computational Foundations of Cognitive Neuroscience, which I wrote for my class. My hope is that this will be a living document, continuously improved as I get feedback.

Almost certainly the best photograph I have ever taken from an Iron Age hillfort of the sun setting over an estuary as summer segues majestically into autumn.

One of my science heroes, Joan Brugge, talks about how science funding cuts are slowing their work on breast cancer prevention--share this widely www.facebook.com/60minutes/vi...

Review @natrevgastrohep.nature.com @i3suporto.bsky.social Mucosal glycans: key drivers of the development of inflammatory bowel disease and a potential new therapeutic target www.nature.com/articles/s41...

I've written an end of year substack post about tracking Trump, where we are ending the year and some implications for Europe and for me personally... christinapagel.substack.com/p/personal-r...

Όλα τα μπράβο του κόσμου στον Κοσμήτορα του Παν. Πελοποννήσου κ. Λεοντάρη για την απόφαση του αυτή και την τεκμηρίωση της. Ανθρωπος με κάκαλα που δεν κρύβεται πίσω από μια απλή υπογραφή σε ένα καταγγελτικό κείμενο.

Ειδικά για τη Βρετανία αυτό δεν ισχύει. Είναι μια σοβαρή περίοδος γρίπης που άρχισε 2-3 βδομάδες νωρίτερα αλλά η εξέλιξη ήταν προβλέψιμη και η κορύφωση έχει ήδη περάσει. Παρακάτω τα data μέχρι 30 Νοεμβρίου. www.kathimerini.gr/visual/infog...

It’s almost like those with vested interests in companies ruining the planet and harming working people don’t want a party in power who’ll hold them to account.

Frightening and very real: as CO2 levels rise, crops become less nutrient-dense, but more calorific and potentially more toxic due to increased lead (among other things) onlinelibrary.wiley.com/doi/10.1111/...

"The worm demonstrates that curiosity-driven science using a simple animal can not only illuminate biology but also help deliver medicines that change human lives (...) Discoveries from C. elegans research have impacted society beyond biomedical outcomes."

This is cool!

Was on Sky News this morning discussing Flu and whether this was a record bad year or not. Also discussed what we could do and the importance of vaccines, ventilation and wearing a mask if you're ill. youtu.be/_PZiU3R7jac

Best review in the field right now, an absolute must-read! Spoiler: This is the first article of a whole series dedicated to the role of public engagement in the control and prevention of infectious diseases @immunolcellbiol.bsky.social. Watch this space!

Nigel Farage is probably delighted today that Reform have the most members of a political party. It doesn't have to be this way. 180,000 and rising. Hope ready to overtake hate. Stand and be counted. Join.greenparty.org.uk

«Ο φραπές είναι ένα ελληνικής επινόησης […] ρόφημα καφέ που αποτελεί σύμβολο του ελληνικού χαλαρού τρόπου ζωής. Έτσι και ο «Φραπές» συμβολίζει με τον πιο αντιπροσωπευτικό τρόπο το παράλληλο σύστημα της χώρας και τη χαλαρή σχέση του με τη δημοκρατία και τη νομιμότητα.» www.lifo.gr/stiles/o-fra...

Absolutely seminal! It’s the Jinx!

🧵 Is it a super flu year? Who knows, but I think the current reporting is stupid. A pissed off thread using data. Firstly - here are today's headlines and some from the last 3 years... spot the difference. 1/10

Συγκλονιστική μαρτυρία. Να το ξαναπούμε: το ότι δεν εμβολίασαν δεν έχει καμία επιστημονική βάση. Σε κάθε ξαφνική (ή όχι και τόσο ξαφνική όπως αποδεικνύεται) μολυσματική επιδημία οι τοπικοί εμβολιασμοί είναι το πιο αποτελεσματικό μέτρο.

Surprisingly, one important “cold case” is not investigated: Lys-type peptidoglycan activates Toll while DAP-type peptidoglycan activates IMD. One of the most widespread claims in the field. And one that is wrong. See Vaz et al Cell Reports 2019 for a full rebuttal.

For those interested - here is an 8 minute discussion of what has happened in the sphere of immigration, nationalism & foriegn policy last week in the US that you might have missed. Will also be doing shorter clips over the week! youtu.be/8I4OoIfTUrU 1/2

From resilient prosecutors to unyielding lawmakers and provocative firebrands, here are 10 people to watch for a clearer view of what’s brewing in European politics @politico.eu Among them, Popi Papandreou EPPO delegated prosecutor www.politico.eu/list/10-to-w...

I got my tickets and I can’t wait to see them live on the 13th here in Oxford!

A great historical account of one of the most fascinating and important clusters of genes in animal evolution. The Master Regulators: The Hox. Despite knowing so much about them since the McGinnis 1984 Cell paper, they retain a core mystery that is difficult to explain. Namely: why clustering?

Important review from @virusesimmunity.bsky.social group, with @jannamoen.bsky.social and Christine Miller, just published: 'The lingering shadow of epidemics: post-acute sequelae across history', a highlight of post-acute infection syndromes (PAIS) through the centuries #LongCOVID

WIN! - a Norman World Exclusive copy of 'HAYWARDxDÄLEK' by HAYWARDxDÄLEK Like, share, and give our page a follow for the chance to win a copy of our limited exclusive of this class industrial hip-hop collab. @relapserecords.bsky.social www.normanrecords.com/records/2117...

Remarkable story of a Georgia high school team who used CRISPR to make a rapid diagnostic test strip for Lyme disease, speeding dx from 2 weeks to days www.cbsnews.com/news/teens-m...

“If the sadness of life makes you tired/and the failures of man make you sigh/You can look to the time soon arriving/When this noble experiment winds down and calls it a day.” “Noble experiment” closing one of the most beautiful records no one knows.

I’m proud to present the main work from my postdoc, 3+ years in making from scratch, my ultimate #MimulusPropaganda up till now: The Moment That Symmetry Breaks. #plantscience #development #imaging #microscopy 🧪🌸🔬 w. Captain Yaowu & @biancatash.bsky.social www.biorxiv.org/content/10.1...

Emergence of a bacterial immune mechanism by incorporating pre-existing cellular machinery. A lesson in the evolution of cell-autonomous defences. Fantastic work by the Bernheim/Patel labs.

Best #Nikolaus 🎅! Our paper on how the 🫁 microenvironment can shape #innate immunity against #viruses is out @sciimmunology.bsky.social This was a herculean effort brilliantly led by @pauljbaker.bsky.social who singlehandedly established the model in the lab during the pandemic. 🧪 #Immunosky 1/9