Dear Academic Bluesky: my department is recruiting two associate professors. We are a diverse and multidisciplinary biochemistry department (with “biochemistry” defined in the widest possible sense). my.corehr.com/pls/uoxrecru...

Γιατί είναι σημαντικό το πρόσφατα δημοσιευμένο paper με τίτλο Fast evolutionary turnover and overlapping variances of sex-biased gene expression patterns defy a simple binary sex classification of somatic tissues 1/6 > elifesciences.org/articles/99602

Thomas Hunt Morgan was born OTD in 1866. If you're ever feeling that your work is uending and unedifying, remember that he once said this: "Two years work wasted, I have been breeding those flies for all that time and I've got nothing out of it." 🌱🐋🧪 #HistSTM

59 mutations that suppress neurodegeneration induced by dNmant depletion in a Drosophila screen, including the known pro-degenerative molecule dSarm. Lots of new potential anti-degeneration drug targets to explore here.

Cell death plays important roles in antiviral immunity across all kingdoms of life. Great panel discussion in @natsmb.nature.com from leading experts in the field highlight open mysteries in how and why cell death functions: www.nature.com/articles/s41...

A clever way to activate the immune system against cancer via the STING pathway www.nature.com/articles/s41...

Hands down the best record for 2025 yet.

Plus Max Roach’s music (very prominent in the soundtrack of the Soundtrack) is incredible!

Choano’s are cool!

Athens

Waning immunity to Japanese encephalitis virus was associated with increased severity of dengue disease in a cohort of patients from Nepal @stjohnlab.bsky.social www.science.org/doi/10.1126/...

One of my favourites from the beginning of the 90s: The magnificent Kristin Hersh and her band the Throwing Muses playing Athens yesterday.

'Early on in her life, Esther defied societal conventions by pursuing biochemistry, against recommendations from her teachers who believed that a career in science was too difficult for women' academic.oup.com/genetics/adv...

'Here, we identify the immunometabolic crosstalk that generates homocysitaconate, a metabolite formed by homocysteine & itaconate adduction catalyzed by S-adenosyl-L-homocysteine hydrolase. Homocysitaconate increases 152-fold during #inflammation and exhibits anti-inflammatory effects.' #Immunology

Home

A reminder you/your lab can support FlyBase at Cambridge through the following link. Every bit helps. Please share if you yourself can't donate. www.philanthropy.cam.ac.uk/give-to-camb...

Ανικανότητα για γερό στομάχι…Κονδύλια για «άριστη» έρευνα που προκηρύσσονται ένα χρόνο πριν τελειώσει η προθεσμία του Ταμείου Ανάκαμψης *για δίχρονα πρότζεκτ!* με αξιολογητές που ο καθένας (!) διαβάζει 100 προτάσεις σε 2 μήνες και πανομοιότυπες-AI chatbox αναφορές με ανεξήγητες βαθμολογίες.

Remembering Mark Stewart on his birthday. Here's a playlist of 20 tracks by Bristol's post-punk pioneer open.spotify.com/playlist/4au...

What a song. Devastating innocence personified. Somehow it was always hard to listen to this wonderful record from beginning to end without breaking down. Radio on!

I'm excited to announce our new biorxiv preprint, wherein we investigate the evolution of the weirdest genetic locus I've ever seen! Behold the tgr genes of the social amoeba, which mediate self/non-self discrimination during facultative multicellularity 🐅 🧵 1/ www.biorxiv.org/content/10.1...

One in 4 people carry one copy of the APOE4 allele, the strongest known genetic risk factor for Alzheimer's disease. We've just learned how that risk is mediated—the immune system erictopol.substack.com/p/our-braini...

The preeminence of the human brain-immune axis is emerging in some unforeseen ways, no less the dawn of an FDA-approved device treatment for autoimmune diseases. erictopol.substack.com/p/our-braini...

Happy birthday to Vini Reilly. Here are The Durutti Column performing a beautiful version of Royal Infirmary from Circuses and Bread on BBC2's The Review Show in 2011 youtu.be/ZzQe7bjnSrI

Πολύτιμο άρθρο του Ν. Ξυδάκη για την συνεχιζόμενη γενοκτονία στη Γάζα και πως ένα τραγούδι ταξιδεύει από τον αμερικάνικο νότο του ´30 στο σήμερα. Η εκτέλεση του 1959 (link) μνημονεύεται στην coda του κειμένου. youtu.be/-DGY9HvChXk?...

East/Jinx/…/Music #1 youtu.be/I1V84Dj3MVM?...

Your sleep pressure is powered by your mitochondria! Sleep, energy, and ageing are all connected through mitochondrial bioenergetics in neurons. Brilliant work from Gero Miesenböck’s lab, just out in Nature @nature.com www.nature.com/articles/s41...

so amazing www.youtube.com/watch?v=0fiL...

Dynamite!

A randomized trial (N>2,100 participants, multi-center) of structured vs self-guided lifestyle interventions in older adults shows the former improved cognitive function jamanetwork.com/journals/jam...

Very cool!

Are most diseases inflammatory?

'Eno' is a 1973 documentary short directed by Alfons Sinniger - made shortly after Brian Eno left Roxy Music, it features the recording sessions for Here Come the Warm Jets #video #stream #download ubu.com/media/video/...

New Order open their 5/9/83 Birmingham concert (with Love will Tear Us Apart). youtu.be/zqch8N82ewQ?...

Many components of human immunity evolved from ancient pathways in bacteria. A beautiful story from @audeber.bsky.social‬ @enzopoirier.bsky.social‬ leverages this evolutionary connection to discover SIRal as a signaling protein in animal TLR-mediated innate immunity. www.science.org/doi/10.1126/...

Psychiatric Genetics Beyond Heritability: Q&A with Michel Nivard ( @michelnivard.bsky.social ) “We look for genes as a means to an end—biology, epidemiology, and etiology of complex human outcomes.” www.psychiatrymargins.com/p/psychiatri...

Some important progress in vaccines 1. Cancer vaccine, potentially universal, to rev up immune system www.nature.com/articles/s41... 2. Lipid nanoparticle improvement for better safety and potency www.nature.com/articles/s41... 3. mRNA delivery by capsule www.statnews.com/2025/07/16/s...

The interesting case of glycan recognition: an evolutionary ancient innate immune mechanism, which primes for better survival to subsequent infections.

And a very good morning to you too. Despite being a huge fan, I didn’t know this B-side. A 7’ to hunt down if ever there was one.

One of the “major” (and damaging) claims in the field was that Lys-type peptidoglycan was recognised by and preferentially activated Toll whereas DAP-type recognised by and preferentially activated IMD. We have disproved that (Vaz et al 2019 Cell Reports), yet there’s no mention here. Why is that?

🚨 Join us tomorrow for this really exciting talk on the interplay between morphogen signalling and tissue organization! 🚨

Good one to listen to these days

Absolute masterpiece for compulsive listening

Evolutionary conservation of the c-Gas/Sting/NF-κB signalling axis in insects to fight off viral infections. Interestingly, mosquitoes that are vectors of human viral pathogens lack this pathway.

The tiger mosquito (Aedes albopictus) has already spread across much of mainland Europe and has been implicated in outbreaks of dengue, chikungunya & Zika viruses. Read our blog post about how we are monitoring these mosquitoes & ways to protect yourself: ukhsa.blog.gov.uk/2024/07/26/h...

Read Parasitology's latest Paper of the Month and discover how wild #monkeys in The Gambia are unlocking new insights into intestinal #parasites and find out why this could be important for human health: cup.org/3TiG8cC 🐒 @bspparasitology.bsky.social

The problem with T cell regeneration and cancer immunotherapy www.jci.org/articles/vie...

Καμπαγιαννης 👇

Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation of monocyte-derived inflammatory CCRL2+ macrophages: @cp-immunity.bsky.social www.cell.com/immunity/ful...

How children master language in early life is one of the central questions of human biology. My fab colleague & friend @carorowland.bsky.social has an important new framework paper, which she breaks down in this fascinating thread. Big implications for how we think about genetic contributions too.👇🧪