📣 Save the date! 🗓️ October 28, 12pm EST Join us for a Space on Tropical AKI, Part 2 🎧 Set your reminder twitter.com/i/spaces/1gq... 🧠 Before the session, test your knowledge! Take the quiz 👉 theisn.outgrow.us/Tropical_AKI Let’s see how much you know about Tropical AKI before the experts dive in! 💪🌴

✅Mayo MGRS Prediction Tool has good performance in finding the risk of MGRS in kidney biopsy in patients with MG 🔆Happy to contribute in this #videoabstract 🎉Thank you @theisn.org and @dilushiwijay.bsky.social for the opportunity @myadla.bsky.social @arvindcanchi.bsky.social

🔥🫀ARNI showed superior cardioprotective effects. May have renoprotective effects as per their molecular mechanism, but the evidence to date applies only to heart failure. Future studies in CKD are needed, perhaps? 🤔

🔥SGLT2 Inhibitors: Game-changers! They reduce HF hospitalisations, preserve GFR, slow CKD progression and improve outcomes in CRS. 🔹 Trials: DAPA-HF, EMPA-KIDNEY show mortality & renal benefits. Do check out the link for the new SGLT2i toolkit there: theisn.org/initiatives/...

See here an Evidence Table of RCTs Comparing Pharmacological Therapy for Fluid Overload and UF in Pts With Acute Decompensated HF doi.org/10.1161/CIRC...

Decongestion Therapy 🔹 Loop diuretics = cornerstone 🔹 Use high doses for diuretic resistance; consider thiazides for synergy. 🔹 UF for refractory cases, but monitor renal function closely. 🔹 Aggressive diuresis improves outcomes even with transient ↑ creatinine.

Key Principles in Rx 1️⃣ Decongestion (diuretics/ultrafiltration). 2️⃣ Neurohormonal modulation (RAASI, SGLT2i). 3️⃣ Volume assessment (CVP, intrarenal Doppler). 4️⃣ Treat underlying systemic disease (e.g., sepsis). 5️⃣ Multidisciplinary care doi.org/10.3390/hear...

What about management? CRS management is about balance. It’s a tightrope walk between relieving congestion & preserving renal function. Let’s talk strategies. Here is the strategy for acute cases, doi.org/10.3390/hear...

Different imaging tech can also provide an overview of tissue damage and the overall function of the heart and kidneys doi.org/10.3390/jpm1...

🔬 Biomarkers of cardiac and kidney injury may provide important information when and can serve to indicate early cardiac or renal injury, the repair process, and long-term sequelae doi.org/10.1161/CIR.... Here is a list

How do we diagnose it? doi.org/10.1161/CIRC... We look at: Biomarkers: NT-proBNP, cystatin C, NGAL, KIM-1 Imaging: Echo (CVP, LVEF), renal US (exclude obstruction) Volume status: Clinical exam + POCUS

Congestion vs Perfusion For years, we thought hypoperfusion drove CRS. 🔥Turns out, congestion is the bigger villain. High venous pressure, intra-abdominal pressure (IAP), and renal compression all hurt GFR. doi.org/10.3389/fphy...

🫀🔥Now, the million-dollar question: Why does this happen? —it’s a cocktail of mechanisms: 🩺 Central players: Congestion → ↓ Renal perfusion RAAS & SNS activation → Maladaptive changes Inflammation & oxidative stress → Organ damage doi.org/10.1161/CIR....

🔑What is CRS? nature.com/articles/nrn... Types of CRS: 1️⃣ Type I: Acute HF → AKI 2️⃣ Type II: Chronic HF → CKD 3️⃣ Type III: AKI → Acute HF 4️⃣ Type IV: CKD → Chronic HF 5️⃣ Type V: Systemic diseases (e.g., sepsis) → Combined dysfunction

🚨 Cardiorenal Syndrome (CRS): A Deadly Duo 🚨 Did you know the heart & kidneys are so intertwined that dysfunction in one can wreak havoc on the other? Let's dive into CRS today. A lucid read for every nephrology & cardiology fellow 🫀🩺 #MedTwitter #ISNTweetorial

🌍 Today is #IgANAwarenessDay! Join the ISN in raising awareness of IgA Nephropathy (#IgAN), a rare but impactful kidney disease. 📚 Explore the ISN's dedicated IgAN resources, all available through the Rare Kidney Diseases Toolkit: www.theisn.org/initiatives/...

As WHA78 unites global health leaders, kidney care must stay a priority. 🗳️ We urge Member States to back the kidney health resolution. Explore the ISN-GKHA Map for key insights. 🔗 http://lite.spr.ly/6... #ISNGKHA #WHA78 #KidneyHealthMatters #UHC

𝗦𝗔𝗩𝗘 𝗧𝗛𝗘 𝗗𝗔𝗧𝗘 for our next @theisn.org Space for #WorldHypertensionDay: "Hypertension and the Kidneys." #Nephpearls #NephSky 🗓️ May 22 🕑 3:00 pm CEST 👉🏼 twitter.com/i/spaces/1jM...

Great meeting with the @ISNEducation social media team; lots of exciting projects on the horizon! We're looking forward to what’s coming next, so stay tuned!

📖 This weekend don't miss our @kidneyint.bsky.social #ISNFridaySelection: Pathological findings of immunotherapy-induced nephrotoxicity in a humanized immune system mouse model www.kidney-internati...

𝗜𝗦𝗡 𝗩𝗜𝗗𝗘𝗢 𝗔𝗕𝗦𝗧𝗥𝗔𝗖𝗧 𝗦𝗘𝗥𝗜𝗘𝗦: The effects of plasma exchange and glucocorticoids on early kidney function among patients with ANCA-associated vasculitis in the PEXIVAS trial. 2025 from @kidneyint.bsky.social www.kidney-internati... #VideoAbstract by @drsumanbehera.bsky.social

#1 Today is World HTN Day! 🧑‍🤝‍🧑1.3 billion people live with HTN, but only 1 in 5 meet BP goals. ⚠️HTN silently drives stroke, heart & kidney failure—and 57% of global deaths. Check this beautiful Infographic by @gabyneph.bsky.social #ISNTweetorial #WorldHypertensionDay

ISN Quiz alert!! 📌HTN remains the leading global contributor to reno cardiovascular death and disability. 📌Take this evidence-based quiz from ISN SoMe team members to assess your knowledge and improve patient care. Here’s the link for the quiz: theisn.outgrow.us/HTN_2025

🎉 20 Years of #WorldKidneyDay! 🎉 Since its launch, World Kidney Day has raised global awareness of kidney health. The 2025 campaign #AreYourKidneysOK highlights the importance of #EarlyDetection in preventing and managing kidney disease. 🔗 Learn more: www.worldkidneyday.o...#WorldKidneyDay!#AreYourKidneysOK#EarlyDetection#KidneyHealthMatters

🌎Are your kidneys OK? Get them checked! And spread kidney awareness! #WorldKidneyDay #NephSky #MedSky @theisn.org @sandhyasuresh.bsky.social @raphapalma.bsky.social

This #InternationalWomensDay, let’s highlight the impact of kidney disease on women. Women with CKD face challenges in fertility, pregnancy, and postpartum care. With rising cases & limited guidance, building obstetric nephrology expertise is critical. #AccelerateAction #IWD2025 @unwomen.bsky.social

11/n #ECNeph @myadla.bsky.social @arunkumarnephro.bsky.social Clue : Zebra Share your experience on "Zebra bodies in LN " @raphapalma.bsky.social @stephanietr612.bsky.social

11/n #ECNeph @arunkumarnephro.bsky.social @myadla.bsky.social Zebra bodies in LN can be due to DIP due to HCQ Here we go ...the causes of Zebra bodies on HPE