Babis Galouzis
@babisgalouzis.bsky.social
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Biologist into evolution and development EMBO fellow at EMBL
This is so cool! It’s also nice to see how careful genetic dissection of loci is still at the forefront of discovery!
add a skeleton here at some point
about 2 months ago
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Check our latest with Yacine Kherdjemil and
@eileen-furlong.bsky.social
and our colleagues, where we show Chip (Ldb1) is essential only at a narrow window of embryogenesis overlapping ZGA. It functionally and physically bridges CBP to Zelda to regulate gene expression.
www.cell.com/molecular-ce...
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Chip (Ldb1) is a putative cofactor of Zelda forming a functional bridge to CBP during zygotic genome activation
Chip/Ldb1 is a crucial cofactor regulating enhancer function and chromatin interactions. Using optogenetics, Galouzis, Kherdjemil et al. show that Chip is only essential during zygotic genome activati...
https://www.cell.com/molecular-cell/fulltext/S1097-2765%2825%2900457-5
6 months ago
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