Sarah Heuer (@heuerwego.bsky.social)

Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons - Acta Neuropathologica Communications Optineurin (OPTN) is an autophagy adaptor protein involved in selective autophagy, including aggrephagy and mitophagy. Pathogenic mutations in OPTN have also been linked to amyotrophic lateral scleros... https://link.springer.com/article/10.1186/s40478-025-02103-y?utm_source=rct_congratemailt&utm_medium=email&utm_campaign=oa_20250902&utm_content=10.1186/s40478-025-02103-y