With CONSULT now ending, we are delighted to share two reports that summarise our findings 1/n CONSULT aimed to support ethical inclusion in research of adults with impaired capacity to consent through series of studies & methodological interventions: 📆5 yrs 📝9 papers (+ 1 in review) 🗝️8 key findings

No.3 #BJGPTop10 Irritable bowel syndrome: Trying low-dose amitriptyline for IBS outweighed patients' concerns doi.org/10.3399/BJGP... @uos-primarycare.bsky.social @hazeleveritt.bsky.social @riddmj.bsky.social @amandafarrin.bsky.social#BJGPTop10#ATLANTISTrial #IBS #DigestiveHealth #PrimaryCare #BJGP #research

I'm doing a webinar in two weeks (15 Oct 1-2pm BST), part of NIHR Research Support Service's Methods Academy series, on the age-old question: should I do a stepped wedge trial? Free registration, details here: tinyurl.com/z6cjvce3 @nihr-rss.bsky.social @wiphcem.bsky.social @qmul-wiph.bsky.social

Great to have so many engaged people in the room! More workshops are planned for 2026. Follow us here and on LinkedIn find out about future training opportunities. www.linkedin.com/company/ukcrc-registered-ctu-network/ #UKCTUNetwork #HTBAGCI #ClinicalTrials

Fern Harvey’s fab poster presentation of her systematic review on process evaluations for complex intervention trials. Better reporting of context, mechanisms of action and fidelity would enable greater learning about successful interventions #ImpSci #EIE2025 @au-primarycareuol.bsky.social

A cluster randomised crossover design incorporates the principles of both cluster trials (where groups of individuals eg wards, schools etc are randomly assigned) and crossover trials where, in this case, the clusters cross over to different treatment/s for set time periods 2/7

At #CCR25, we saw some trials use a #CompositeOutcome (an endpoint that combines more than one outcome into a single measure) & also saw some of the problems these can throw up. I have discussed these before but thought it would be useful to revisit 1/9 #MethodologyMonday #120

🚀 Exciting News! 🚀 Interested in or leading a clinical trial? Want to be the best Chief Investigator you can be? This updated course is for you! tinyurl.com/HTBAGCI #ClinicalTrials #CITraining @leedsctru.bsky.social @amandafarrin.bsky.social

Phew: ResearchFish submitted again for another year ✅️

A common issue in trials is how to accommodate multiple important outcomes. Approaches include composite outcomes or using the win ratio method (I have posted on these before). A newer method is the #DOOR (Desirability of Outcome Ranking) approach 1/7  #MethodologyMonday #113

📢 Delighted our CHART trial is now OPEN to recruitment Massive effort from our @complexleedsctru.bsky.social trial team, @drandyclegg.bsky.social @vickigphysio.bsky.social & many others to get this complex study ready to go 🎉 🙏 @nihr.bsky.social for funding

Currently low response rates from CTU Directors (n=5), Programmers/Data Managers (n=0), & QA Managers (n=3) working in clinical trials. We need to know what these groups think the challenges are for greener trials. forms.office.com/e/fkeLD8HbMA Please complete &RT @ukctunetwork.bsky.social

Consider what to report about your rehabilitation intervention? Here's a newly published TIDieR Rehab checklist bmjopen.bmj.com/content/14/1...

Follow @freshstart-uk.bsky.social for all updates from our @leedsctru.bsky.social @nihr.bsky.social programme grant. We've just moved over to this platform 🙂

Another link to survey as initial link problematic for some - forms.office.com/e/fkeLD8HbMA

Do you work on clinical trials? We need your help to understand the challenges to designing & delivering greener trials. Only 30 responses so far but we can all have a say on this topic. Please take 10 minutes to tell us what you think tinyurl.com/GreenTrials Please share across your networks

Interesting historical principles of clinical trial conduct … Rule 5 “the medical statistician has to be competent” … sure hope we’ve got that one sorted!

An issue that often comes up is how to set a “non-inferiority margin” in a non-inferiority trial and how to ensure it is appropriate 1/8 #MethodologyMonday #109

Welcome to bluesky @complexleedsctru.bsky.social 🎉 Please do follow our Complex Interventions Division account for our news of our training opportunities, trial progress and results, as well as signposting to relevant resources for Complex Intervention trialists 👇

We've frustratingly allowed "real world" to become a deceptive synonym for "observations we happened haphazardly to make". I'd say half the studies that come to me now, the majority of which are useful but modest clinical audits, will have "real world" in the proposal title. It's magic!

I am not that surprised that more women quit academic publishing than men- this chimes with data showing fewer women get their papers published, grants funded if they lead them and that more women get pushed into support roles. We do need to do more to support and mentor female staff. 🧪

Snow day #Yorkshire #Langsett

Want to know how to report a cluster-crossover trial … the CONSORT extension reporting guidance is out 😊 www.bmj.com/content/388/...

We're running our annual online Masterclass in Complex Interventions Evaluations over 3 days in January and February. Come and learn from our expert team of complex interventions trialists at @leedsctru.bsky.social Register now to reserve your place. Deadline 24 Jan. Link below 👇

Just a wee bit of snow in Yorkshire 🥶❄️

🤢 horrifying piece of work, which we’ll see idiots quoting. For goodness sake @jclinepi.bsky.social

Happy New Year! May your 2025 be healthy, prosperous, and full of interesting research questions to explore!

Beautiful light from the late December sun in one of my favourite places today #PeakDistrict #LadyBower to #LostLad and back

Happy Boxing Day from a very sunny Yorkshire 😎🎄 Perfect temperature inversion around #EmleyMoorMast

With the approaching the start of the holidays please remember that HOW to ‘switch off’ is your thing. There’s no manual. Whatever suits you. Checking emails is not a crime during this time but it’s good practice -if you email back- to schedule sending for when the holiday is over.

Beautiful day for graduation 🎓 ceremony. So proud of Dr Sadia Ahmed: our 1st @mrcnihrtmrp.bsky.social PhD student to graduate from @leedsctru.bsky.social Grateful for my co-supervisors @suzrich.bsky.social & Andy Clegg And thank you for the beautiful flowers Sadia: but you did the hard work

I love PhD graduation ceremonies. It is a celebration of watching someone grow in skills and confidence. Congrstulations Dr Sadia Ahmed. @amandafarrin.bsky.social @drandyclegg.bsky.social

-ology = study of methodology = study of method trial methodology = study of the method of clinical trials, including scientific & operational aspects Importantly, a trial methodologist is not necessarily an expert in trial design and analysis

Interest in learning more about Multiphase Optimisation Strategy (MOST) framework & optimisation trials? New CPD course at University of Leeds on this topic, from 22nd to 24th Jan. The early bird registration deadline is 20th Dec. Read more: medicinehealth.leeds.ac.uk/dir-record/r...

Q what should people do in response to the new guidance? 1) be aware of it; 2) read it and consider how you might change what you do; 3) planned/ongoing engagement between WHO and national-level regulators...

Vasee Moorthy of WHO talks about the need for proportionate clinical trials training - and not being too led by ICH GCP in all settings/trial types given its origins in the world of drug development

Recording of our CONSULT training launch webinar now added to the website, alongside details about how to access the e-learning: 🔗https://capacityconsentresearch.com/training Many thanks to the panel @kerryhood.bsky.social @amymrussell.bsky.social @markjayes.bsky.social & others! #Inclusivity

📢Now live📢 CONSULT e-learning on trials involving adults with impaired capacity to consent - 4 core modules, case studies, links to resources, free to access, download a certificate on completion 🔗https://www.capacityconsentresearch.com/training @kerryhood.bsky.social @ukctunetwork.bsky.social

Innovative trials in stroke showcased by @amandafarrin.bsky.social today at #UKSF24

Promoting hybrid and remote de-centralised elements and outcome selection for platform trials

If you're interested in how to measure psychological problems after stroke, please consider filling out our quick survey linktr.ee/leeds_ctru?u... @leedsctru.bsky.social

Looking for people to join our stakeholder group to develop a core outcomes set for trials of interventions designed to treat/prevent psychological problems post-stroke! You may have spotted this slide in @amandafarrin.bsky.social's talk at #uksf24 this morning...

Prof Amanda Farrin on the future of trial design & need for platform designs; faster, cheaper, sooner evidence available for practice. Challenging design but very much needed across acute and life after stroke #uksf24 @amandafarrin.bsky.social

Come and do a Dunhill Medical Trust #PhD with me and @jufrost.bsky.social looking at #CGA for people with #heartfailure and #frailty as part of the @nihr.bsky.social funded CHART trial and #processevaluation www.exeter.ac.uk/study/fundin...

And we're off. @lisakidd22.bsky.social welcoming us all to #UKSF24. Looking forward to 2 days of all things stroke-related

On my way to #UKSF2024 🙂 @bethancopsey.bsky.social & I are hosting a Table in the Research World Cafe at 12 noon. Come and tell us about the opportunities & challenges for #ClinicalTrials & how the @thestrokeassoc.bsky.social research strategy can support more trials in the future #HaveYourSay

First up on my #uksf24 agenda for today is co-hosting a table @thestrokeassoc.bsky.social's Research World Cafe session! Come and join us - we'd love to hear your thoughts about recruitment and retention and how the Stroke Association might support it #ukstrokeforum2024 @auasresearch.bsky.social

PLEASE SHARE: Registration is now open for the next Introduction to Causal Inference Course for Health & Social Scientists (7-11 July 2025, Leeds, UK). See more info & register here: www.causal.training Note, we are not planning any other courses until 2027. #CausalIntroCourse #EpiSky #CausalSky

*Risk-proportionate* trial monitoring: a key element of trial integrity. Helpful 🧵from @marionkcampbell.bsky.social 👇