Now online! Generation of antigen-specific paired-chain antibodies using large language models

I am excited to share our new preprint on the CAGE complex, a mysterious hollow protein complex that I first saw years ago while surveying Tetrahymena ciliary lysate www.biorxiv.org/content/10.1... #cilia #protistsonsky 🧬🧪

Our preprint, in collaboration with Rino Rappuoli & Emanuele Andreano, is out! Co-led by colleagues at TLS, my grad student Ling Zhou @lingzhou.bsky.social, and postdoc Emily Rundlet @cryoemily.bsky.social, we identified OPG153 as a poxvirus bnAb target via B cell isolation & AlphaFold3 prediction.

Latest preprint from the lab, many years in the making! By combining #cryoEM with #AlphaFold3 modelling, we propose that norovirus NS3 forms a transmembrane RNA translocase. This could have big implications for our understanding of viral replication & assembly (🧵) www.biorxiv.org/content/10.1...

Grateful to be a part of such a fun project led by my labmate @luqiang.bsky.social!

Check out our latest study, led by grad student Ryan McCool @rmccool.bsky.social‬, in collaboration with Vaccine Company. We were able to stabilize EBV gB in the prefusion conformation, determine its cryo-EM structure to 3.1 A, and assess its immunogenicity in mice. www.biorxiv.org/cgi/content/...

Happy to finally see this study published, a great collaboration between academic, government and industry labs! We show that CCHFV GP38 can induce vascular leak and that this can be prevented by protective but not virus-neutralizing antibodies! www.science.org/doi/10.1126/...

Wow! UT Austin’s Jason McLellan will be inducted into the National Inventors Hall of Fame for his work on structure-based vaccine design that led to development of vaccines to fight COVID-19 & RSV. @mclellanlab.bsky.social @utaustin.bsky.social #COVIDVaccine cns.utexas.edu/news/announc...

I’m super excited to see this work out from my lab/PhD-cohort-mate @elizabeth-mcfadden.bsky.social. By engineering and structurally analyzing a soluble gp38-Gn-Gc complex, she develops new insights for CCHFV and other type II viral fusion proteins alike. Definitely worth the read!

Congratulations Elizabeth! Great collaborative effort with our colleagues Kartik Chandran, Andrew Herbert, Stephanie Monticelli and more!

I'm happy to announce that our paper is now online in Cell! This study was the result of a highly collaborative effort from many scientists. Please read it here: www.cell.com/cell/fulltex... (1/3)