Very excited to share our latest preprint describing the isolation and characterization of neutralizing HCoV-229E-directed antibodies from a human donor! Great collaboration between DHVI and the Baric and Sheahan (@timothysheahan.bsky.social) labs at UNC. www.biorxiv.org/content/10.1...

Check out our latest study, led by grad student Ryan McCool @rmccool.bsky.social‬, in collaboration with Vaccine Company. We were able to stabilize EBV gB in the prefusion conformation, determine its cryo-EM structure to 3.1 A, and assess its immunogenicity in mice. www.biorxiv.org/cgi/content/...

I’m super excited to see this work out from my lab/PhD-cohort-mate @elizabeth-mcfadden.bsky.social. By engineering and structurally analyzing a soluble gp38-Gn-Gc complex, she develops new insights for CCHFV and other type II viral fusion proteins alike. Definitely worth the read!