Maximilian Frosch
@mfrosch.bsky.social
📤 38
📥 75
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Neuropathology | Neuroimmunology | @PrinzLab | @University Clinic Freiburg
pinned post!
Our brains rely on microglia—they deliver the lysosomal enzyme β-hexosaminidase to neurons to clear toxic GM2 buildup. And transplanted microglia-like cells can rescue neurodegeneration. Just published in Nature! 🧠 🔗
www.nature.com/articles/s41...
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Microglia–neuron crosstalk via Hex–GM2–MGL2 maintains brain homeostasis - Nature
Nature - Microglia–neuron crosstalk via Hex–GM2–MGL2 maintains brain homeostasis
https://www.nature.com/articles/s41586-025-09477-y
6 months ago
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Maximilian Frosch
Journal of Experimental Medicine
2 months ago
Chatterjee, Zeiser et al. report that microbiota depletion exacerbates acute graft-versus-host disease in the central nervous system, driven by microglial activation and T cell infiltration.
rupress.org/jem/article/...
📘 In our
#Neuroscience
collection:
rupress.org/jem/collecti...
#SfN25
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Maximilian Frosch
3 months ago
🎉 Join the International Symposium of CRC1160! We are excited to announce the upcoming International Symposium of the Collaborative Research Center 1160! 📅 October 8-10, 2026 📍 Freiburg, Germany 🔬 Theme: Impaired Immunity: from Immunopathology to Immune Reconstitution
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Maximilian Frosch
Immunity
3 months ago
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Sensory neurons shape local macrophage identity via TGF-β signaling
Specialized macrophages are known to persist within tissue niches, but the molecular mechanisms guiding their sustained functional adaptation remain unclear. Kolter and Döring et al. show that local interactions between sensory nerves and macrophages activate TGF-β, which imprints and maintains nerve-associated macrophages that contribute to regeneration after tissue injury.
http://dlvr.it/TNhqhM
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Maximilian Frosch
CIBSS – Centre for Integrative Biological Signalling Studies
3 months ago
🎬 Great feature from Baden TV Süd on
@uni-freiburg.de
's efforts & successes in its
#ExcellenceStrategy
! 🌍 The
#ExcellenceClusters
#CIBSS
and
#FutureForests
play a vital role in driving interdisciplinary research and innovative applications for real-world impact. ➡️ Watch here:
kurzlinks.de/w7wj
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Ein Jahr vor der Entscheidung: So will die Uni Freiburg wieder Exzellenz-Universität werden
Ein Jahr vor der Entscheidung: So will die Uni Freiburg wieder Exzellenz-Universität werden | Die Uni Freiburg war eine der ersten deutschen Exzellenz-Universitäten seit 2007, verbunden mit hohem inte...
https://kurzlinks.de/w7wj
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Great recap of the story and the breakthroughs behind the 2025
#NobelPrize
in Physiology or Medicine! 🏅🏅🏅
add a skeleton here at some point
4 months ago
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reposted by
Maximilian Frosch
Michael Platten, MD
4 months ago
The immunology of brain tumors | Science Immunology
www.science.org/doi/10.1126/...
Happy to share this review article by
@lukasbunse.bsky.social
, Theresa Bunse and I
@platten-lab.bsky.social
, Michael Kilian, Fran Quintana
@quintanalabhms.bsky.social
.
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The immunology of brain tumors
The cellular and molecular determinants of the antigenicity of brain tumors and the immunosuppressive brain tumor microenvironment are reviewed.
https://www.science.org/doi/10.1126/sciimmunol.ads0449
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🙏🏻
add a skeleton here at some point
4 months ago
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Maximilian Frosch
Science Magazine
4 months ago
“This is an immensely exciting development for the Huntington’s field.”
https://scim.ag/4nnW62z
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In a first, a gene therapy seems to slow Huntington disease
Small study suggests uniQure drug could be first successful treatment for devastating brain disorder
https://scim.ag/4nSAwmF?utm_campaign=Science%20Magazine&utm_source=bluesky&utm_medium=ownedSocial
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reposted by
Maximilian Frosch
Cell - a Cell Press journal
5 months ago
And a Review on interferons in health and disease
www.cell.com/cell/fulltex...
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Interferons in health and disease
The cytokine messenger proteins known as interferons are central to protective immune responses against infections, but they are also involved in inflammatory and autoimmune diseases. This review maps...
https://www.cell.com/cell/fulltext/S0092-8674(25)00746-9
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Maximilian Frosch
Universität Freiburg
5 months ago
Die
#UniversitätFreiburg
hat im renommierten
#ShanghaiRanking
den 5. Platz von 51 deutschen Institutionen erreicht und gehört weiterhin zu den Top 101–150 Universitäten weltweit. ➡️ Mehr dazu:
ufr.link/shanghai-2025
#Ranking
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Maximilian Frosch
Nature
5 months ago
Nature research paper: Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1
go.nature.com/4oF4v2G
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Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1 - Nature
Microglia-derived IGF1 promotes the proliferation of GABAergic progenitors and neuroblasts in the human medial ganglionic eminence, contributing to the extended production of GABAergic neurons and an expanded cognitive capacity in the human brain.
https://go.nature.com/4oF4v2G
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Our brains rely on microglia—they deliver the lysosomal enzyme β-hexosaminidase to neurons to clear toxic GM2 buildup. And transplanted microglia-like cells can rescue neurodegeneration. Just published in Nature! 🧠 🔗
www.nature.com/articles/s41...
loading . . .
Microglia–neuron crosstalk via Hex–GM2–MGL2 maintains brain homeostasis - Nature
Nature - Microglia–neuron crosstalk via Hex–GM2–MGL2 maintains brain homeostasis
https://www.nature.com/articles/s41586-025-09477-y
6 months ago
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reposted by
Maximilian Frosch
Dominic Grün
6 months ago
Join our "Advances in Single-Cell Technologies" meeting in December in Freiburg, co-organised with Marco Prinz and
@katrinkierdorf.bsky.social
. Excellent line-up of speakers covering spatial technologies, lineage tracing, computational methods, and more.
www.uniklinik-freiburg.de/single-cell-...
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Maximilian Frosch
Nature Neuroscience
6 months ago
Characterizing plaque-associated
#microglia
(PAM) and non-plaque-associated microglia (non-PAM) in a mouse model of Alzheimer's disease; non-PAM modulate cell population expansion in response to amyloid deposition and rapidly respond to environmental cues
www.nature.com/articles/s41...
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Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease - Nature Neuroscience
The dynamics of microglia states adjacent to or far from amyloid-beta plaques are unclear. Here the authors show that non-plaque-associated microglia modulate the cell population expansion in response...
https://www.nature.com/articles/s41593-025-02006-0?utm_source=bluesky&utm_medium=social&utm_campaign=neuro
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