Somatotopic organization of brainstem analgesic circuitry | Science www.science.org/doi/10.1126/...

Once you’ve done that, there is also a link in the thread to contact the lawyers who are filing the lawsuit with your details and details of your work.

First party to prioritize getting rid of Teams and SharePoint over screwing with immigrants will coast to landslide victories in national and EU elections

Hi all, I’m going to be writing an article that looks at when in their careers scientists feel they do their most satisfying work… I’m sure it’ll vary hugely but if you’d like to help provide a starting point please fill in this survey - and please share! survey.alchemer.com/s3/8407348/C...

Our paper showing decreased KCC2 expression in the human spinal cord in people who died with a history of neuropathic pain is now published in PAIN: journals.lww.com/pain/abstrac... Great work from @oliviadavis.bsky.social and the teams of the De Koninck and Hildebrand labs. ❤️ 🇨🇦 collabs!

Happy birthday Brenda Milner! 🧠🎉 Today is her 107th birthday, she's a legend, a superhero.

And the office of Pain Policy and Planning was eliminated. That office has coordinated pain research across NIH for ages and played a key role in many important initiatives.

Sometimes the answer is an absinthe fountain. Saturday night at The Parlour with @skochlab.bsky.social working out what the question is.

Yes it’s three penguin kites on a beach in Le Touquet, what of it?

The world is your oyster, quite literally here in Le Touquet in Normandy. I do enjoy a challenge…

A much needed escape to the bucolic Kent countryside for some vintage motorcycle racing. The roar of ancient machines and the perfume of Castrol R in the air. Delicious!

Just thinking about how much time I spend applying for grants and how this dumb shit is gonna spend 20 million or something on this dumb nonsense and will publish it in cureus next to Vinay Prasads latest paper “why Arnold ventures should be allowed to buy people and execute them for sport”

🧠🐭📊🔬🧬BIG PREPRINT UPDATES: Mimicking opioid analgesia in cortical pain circuits We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with our synthetic opioid gene therapy www.biorxiv.org/content/10.1... 1/15

Fascinating new article from the Basbaum Lab! Elora Midavaine et al. show that regulatory T cells can curb pain via endogenous opioid signaling - but only in female mice. #PainResearch #Neuroimmunology #Tregs #SexDifferences #Enkephalin www.science.org/doi/10.1126/...

I may be tired and a little hoarse, but as I said again and again on the Senate floor, this is a moment where we cannot afford to be silent, when we must speak up.

How is the input of the different kinds of primary sensory neurons responding to heat and mechanical stimuli summarized in the spinal cord? Check out our recent study. www.nature.com/articles/s41...

Michael Gold, founding president of USASP, explains why industry can’t fill the gap in funding from cuts to NIH in letter to the editor of local paper (Pittsburgh Post Gazette)

It’s that time of the day

Happy St Patrick's Day! I shall be bathing in Guinness later, hopefully.

Halle-bloody-lujah!

An opportunty to jump at!

The Bordeaux Summer on pain circuits. Five days of talks and hands-on workshops of cutting edge techniques. A few places still available, deadline is the 31st of March. Its an amazing opportunity not to be missed! bss-neuropain.u-bordeaux.fr/en/

I’ve often wondered about this. Fascinating and thought-provoking

Once upon a time, in the late 1800s, people in Japan got really into breeding mice. Coloured mice. Patterned mice. Even mice that danced. They became known as Japanese Fancy Mice, and that caught the attention of researchers in Europe and America, who imported them for study. 2/n

A thingamajig (AKA a whatchamacallit) in ten different languages… 10. Chingadera (Mexican Spanish) 9. Zamazingo (Turkish) 8. Habbijabbi (Bengali) 7. Yoke (Hiberno English) 6. Shismoo (Arabic) 5. Haghawagha (Pashto) 4. Trucmuche (French) 3. Burungo (Sheng) 2. Intazinga (Zulu) 1. Dingsbums (German)

How does a neuron get its activity? 👀 Check out our latest preprint, where we tracked the activity of the same neurons throughout early postnatal development: www.biorxiv.org/content/10.1... see 🧵 (1/?)

It seems trivial to be posting a photo of a drink given the tales of woe here from our US friends and colleagues. However this one seems appropriate (and delicious!)from the ever reliable @anatomyofadrink.bsky.social The Guardian Angel

A pain summer school like no other!

Hot off the press: Our recent publication in British Medical Journal: Moments that matter: childhood pain treatment shapes pain for life-we can do better every time in every child bmcmedicine.biomedcentral.com/articles/10....

"I've got this opioid, great for any type of pain, honest. And I think people are going to love it..."

Wondering about the sorts of pain research questions we ask in the lab? See this short video by the Medical Research Foundation on work they generously funded. A reminder that we have a postdoctoral position opening up in the next month! @ucllifesciences.bsky.social @ucl-neurodomain.bsky.social

@liamdrew.bsky.social Rob Auton this evening, courtesy of Liam. I could blather on enthusiastically, as is only right and proper, but see if you like it. I do. www.robauton.co.uk/body

A little delicate after last night’s Burn’s Night. Here’s the wee beastie before and after cooking

Decreased KCC2 expression in the human spinal dorsal horn associated with chronic pain and long-term opioid use https://www.biorxiv.org/content/10.1101/2025.01.19.633733v1

Friday cocktail. A take on the Cameron’s Kick but with poitin and Laphroaig. A full head-on assault of moonshine and peat to welcome the weekend. I may need another.

It’s been an increasingly stressful first week back, and so to Charles Baker Jr’s ‘The Gentleman’s Companion Volume II, an Exotic Drinking Book’ for solace and advice. Never fails. Happy Friday!

Once more for reviewers in the back: sex differences in behavioral outcomes are very often NOT a product of the estrous cycle and demanding that scientists build estrous metrics into experimental design only shows your own biases about how females (but not males) are primarily hormone-driven.

A reminder: for genotypes to produce phenotypes, they have to go through development

1/ 🧠 Excited to share our new preprint: Convergent state-control of endogenous opioid analgesia We uncover how cognitive + contextual factors—like injury, fear, and placebo—modulate pain through dynamic opioid signaling in the periaqueductal gray (PAG) biorxiv.org/content/10.1...

Traditional New Year’s Day morning swim in the welcoming azure waters of the North Sea. Bracing!

It is the time of year for a corpse reviver, and where better to drink one than in the place of its invention; the American Bar at The Savoy. A fitting joint birthday celebration with @skochlab.bsky.social

When your ten year old can’t quite let go of the idea of Santa…

Christmas carol service in Canterbury cathedral. The ethereal sound of the choir reverberating in that 13th century vaulted space is other-worldly. Fortunately heavy on the singing, light on the god business.

A tour of the Christmas lights of London starts with a quick sharpener in Sketch. The Winter Solstice: reposado tequila, cactus pimento liqueur, maple syrup, lemongrass, ginger, orange, Mezcal.

Interested in potential sex differences in gene expression in adult mouse spinal cord neurons? Excitatory versus inhibitory dorsal horn neurons? Check out this online tool and technical report that enables you to dig deeper. 👇😊 onlinelibrary.wiley.com/doi/10.1002/...

It’s the time of the year we must give thanks to Jeffrey Morgenthaler and the life-affirming properties of eggnog. Cheers!

We have an exciting postdoc opportunity to study the spinal circuits involved in spatial restriction of pain. Please spread the word and get in touch if you’re interested in joining our team. Application details to follow! @uclnpp.bsky.social @ucllifesciences.bsky.social #painscience #neuroskyence

On this day in 1933 prohibition ended. Nothing could be more suitable to mark the occasion than the Scofflaw.