Not being in a cage makes mice less stressed, feels like one of those things that shouldn't take a massive experiment to verify, but here we are. I suspect this may lead, down the line, to requiring new lab standards to certin experiment with these animal models. 🧪 Link: www.cell.com/current-biol...

Kent

.... when injected at large doses in pregnant mice.

Oh to be a little Tardigrade walking across a microscopic slide. 🫧🐻🧪

Lab Christmas party enhanced by some disguised Morgenthaler Magic: tequila-sherry egg nog. If you have a crowd, this will please

That’s the Christmas tree sorted

That's me in the corner...

From January 1st 2026, the CNRS will cut access to one of the largest commercial bibliometric databases, Clarivate Analytics' Web of Science, along with the Core Collection and Journal Citation Reports.

"Come join us!!!" —member of academic search committee that will receive 200 applications for one role and may in fact hire zero people for it

Big new paper from us published yesterday: The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain www.science.org/doi/10.1126/... Led by @hajisciencebaji.bsky.social in my lab and a wonderful collaboration with Matthew Dalva's lab at Tulane

Very glad to share our newest paper published in Molecular Psychiatry: Investigating milk-derived extracellular vesicles as mediators of maternal stress and environmental intervention www.nature.com/articles/s41... fun collab w/ @jordanmarrocco.bsky.social. Please enjoy! #OpenAccess #MaternalHealth

A huge thanks to the fabulous Prof Deirdre Logan who has so expertly steered the helm of the Pediatric Pain Letter for the last 11 years. We are so thankful for your expert editorial work Deirdre. You can read Deirdre's outgoing Editorial letter here -

When people celebrate the individual genius of folks in science, they should also mourn the collective loss of genius of folks who were actively discouraged or disadvantaged from a career in science because of the same person(s)

Too much admin and students not engaged? Its nothing new!

Found a bar in London for game 6. It’s a Phillies bar, got to be a good omen.

Time to dust off this old thing #BlueJays

Prof Selina Wray will join us as our careers keynote, sharing her journey from a working class background and part time work through to a professorship, and Dr Carole Torsney, our research keynote, will tell us about her preclinical research on sex & gender disparities in pain.

Somatotopic organization of brainstem analgesic circuitry | Science www.science.org/doi/10.1126/...

Once you’ve done that, there is also a link in the thread to contact the lawyers who are filing the lawsuit with your details and details of your work.

First party to prioritize getting rid of Teams and SharePoint over screwing with immigrants will coast to landslide victories in national and EU elections

Hi all, I’m going to be writing an article that looks at when in their careers scientists feel they do their most satisfying work… I’m sure it’ll vary hugely but if you’d like to help provide a starting point please fill in this survey - and please share! survey.alchemer.com/s3/8407348/C...

Our paper showing decreased KCC2 expression in the human spinal cord in people who died with a history of neuropathic pain is now published in PAIN: journals.lww.com/pain/abstrac... Great work from @oliviadavis.bsky.social and the teams of the De Koninck and Hildebrand labs. ❤️ 🇨🇦 collabs!

Happy birthday Brenda Milner! 🧠🎉 Today is her 107th birthday, she's a legend, a superhero.

And the office of Pain Policy and Planning was eliminated. That office has coordinated pain research across NIH for ages and played a key role in many important initiatives.

Sometimes the answer is an absinthe fountain. Saturday night at The Parlour with @skochlab.bsky.social working out what the question is.

Yes it’s three penguin kites on a beach in Le Touquet, what of it?

The world is your oyster, quite literally here in Le Touquet in Normandy. I do enjoy a challenge…

A much needed escape to the bucolic Kent countryside for some vintage motorcycle racing. The roar of ancient machines and the perfume of Castrol R in the air. Delicious!

Just thinking about how much time I spend applying for grants and how this dumb shit is gonna spend 20 million or something on this dumb nonsense and will publish it in cureus next to Vinay Prasads latest paper “why Arnold ventures should be allowed to buy people and execute them for sport”

🧠🐭📊🔬🧬BIG PREPRINT UPDATES: Mimicking opioid analgesia in cortical pain circuits We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with our synthetic opioid gene therapy www.biorxiv.org/content/10.1... 1/15

Fascinating new article from the Basbaum Lab! Elora Midavaine et al. show that regulatory T cells can curb pain via endogenous opioid signaling - but only in female mice. #PainResearch #Neuroimmunology #Tregs #SexDifferences #Enkephalin www.science.org/doi/10.1126/...

I may be tired and a little hoarse, but as I said again and again on the Senate floor, this is a moment where we cannot afford to be silent, when we must speak up.

How is the input of the different kinds of primary sensory neurons responding to heat and mechanical stimuli summarized in the spinal cord? Check out our recent study. www.nature.com/articles/s41...

Michael Gold, founding president of USASP, explains why industry can’t fill the gap in funding from cuts to NIH in letter to the editor of local paper (Pittsburgh Post Gazette)

It’s that time of the day

Happy St Patrick's Day! I shall be bathing in Guinness later, hopefully.

Halle-bloody-lujah!

An opportunty to jump at!

The Bordeaux Summer on pain circuits. Five days of talks and hands-on workshops of cutting edge techniques. A few places still available, deadline is the 31st of March. Its an amazing opportunity not to be missed! bss-neuropain.u-bordeaux.fr/en/

I’ve often wondered about this. Fascinating and thought-provoking

Once upon a time, in the late 1800s, people in Japan got really into breeding mice. Coloured mice. Patterned mice. Even mice that danced. They became known as Japanese Fancy Mice, and that caught the attention of researchers in Europe and America, who imported them for study. 2/n

A thingamajig (AKA a whatchamacallit) in ten different languages… 10. Chingadera (Mexican Spanish) 9. Zamazingo (Turkish) 8. Habbijabbi (Bengali) 7. Yoke (Hiberno English) 6. Shismoo (Arabic) 5. Haghawagha (Pashto) 4. Trucmuche (French) 3. Burungo (Sheng) 2. Intazinga (Zulu) 1. Dingsbums (German)

How does a neuron get its activity? 👀 Check out our latest preprint, where we tracked the activity of the same neurons throughout early postnatal development: www.biorxiv.org/content/10.1... see 🧵 (1/?)

It seems trivial to be posting a photo of a drink given the tales of woe here from our US friends and colleagues. However this one seems appropriate (and delicious!)from the ever reliable @anatomyofadrink.bsky.social The Guardian Angel

A pain summer school like no other!

Hot off the press: Our recent publication in British Medical Journal: Moments that matter: childhood pain treatment shapes pain for life-we can do better every time in every child bmcmedicine.biomedcentral.com/articles/10....

"I've got this opioid, great for any type of pain, honest. And I think people are going to love it..."

Wondering about the sorts of pain research questions we ask in the lab? See this short video by the Medical Research Foundation on work they generously funded. A reminder that we have a postdoctoral position opening up in the next month! @ucllifesciences.bsky.social @ucl-neurodomain.bsky.social