Very happy to see our paper “Cancer-associated USP28 missense mutations disrupt 53BP1 interaction and p53 stabilization” featured in the Nature Communications Editors’ Highlights (Cancer). Many thanks to the editors for highlighting our work. www.nature.com/ncomms/edito...

New in @natcomms.nature.com, OIST researchers describe how cancer cells lose their sense of time to evade stress responses – revealing new insights that could shape anti-cancer treatments. www.oist.jp/news-center/... Or read the full paper at www.doi.org/10.1038/s41467-025-66341-3

Missense mutations in the C-terminus region of USP28 discovered to disrupt 53BP1 interaction and p53 stabilization @meitinger.bsky.social doi.org/10.1038/s414...

Our study on the mitotic stopwatch has been published. We demonstrate that USP28 interacts with 53BP1 to stabilize p53 and show that cancer cells frequently harbor mutations that impair stopwatch assembly, thereby suppressing the mitotic stress response. rdcu.be/eTPU2

Congratulations to Hamzah for receiving the EMBO Molecular Medicine Poster Prize at #MBSJ2026. Well deserved! www.aeplan.jp/mbsj2025/en-...

We’re recruiting a Postdoctoral Researcher at OIST (Okinawa, Japan) to explore how mitotic stress shapes aging. If you’re excited about cell biology, aging, and mechanistic discovery, we’d love to hear from you. More info: www.oist.jp/careers/post... Website: www.oist.jp/research/res...

The mitotic stopwatch synergizes with mild p53 activation to halt cell proliferation https://www.biorxiv.org/content/10.64898/2025.12.02.691971v1

If you’re interested in aneuploidy, mark your calendar! The FASEB SRC on the Consequences of Aneuploidy will be held Sept 28 - Oct 1, 2026 in Melbourne, Florida. Many speaking slots are reserved for early-career researchers. Please help spread the word! events.faseb.org/event/Aneupl...

Join us for the #CellDivision2026 meeting in Okinawa. Abstract Submission Deadline: Nov 3. www.oist.jp/conference/c...

Join us for the Cell Division Meeting in the Pacific Island setting of Okinawa. Hosted at OIST, this symposium brings together leading researchers to explore emerging roles of the cell cycle in development, cancer, and aging. Registration now open: www.oist.jp/conference/c...

The OIST Graduate School has opened a Special PhD Admissions Portal for students currently enrolled in, or accepted to, universities in the U.S. #PhDprogram www.oist.jp/admissions/s...

Excited to share our new preprint on @biorxivpreprint! We show that USP28 mutations found in cancer block its interaction with 53BP1, disrupting p53 stabilization. Check out the full story... @Midori_RuruOta www.biorxiv.org/content/10.1...

Check out our review on "PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential". Everything you need to know about centriole duplication, mitotic stopwatch and TRIM37-mediated cancer-specific vulnerabilities. onlinelibrary.wiley.com/doi/10.1002/...

We wish you Happy Holidays from Okinawa!

A prolonged mitosis is characteristic of defects that drive genome instability. What are the underlying causes and broader implications of prolonged mitosis? Check out our review... authors.elsevier.com/sd/article/S...

Interested in Base Editing and Genetic Screening? Check out our method chapter: link.springer.com/protocol/10.... Esther Ng did an excellent job developing these methods in our lab. The constructs will soon be available on @addgene.bsky.social Many thanks to OIST for supporting open access!

@MBSJ 2024 in Fukuoka