Finished this last night.Never read any Le Carré before and now I have lots to read. Such a great book. Think in my head I'd lumped him in with the Dick Francis type popular novels of my childhood. Well, I was an idiot.

Have ideas for your own, independent research program in Theoretical Biology? Then come and join us as a Group Leader at the @mpi-evolbio.bsky.social in Plön, Germany!

1/3 🚨New Perspective🚨 (@genetics-gsa.bsky.social) "When evolvability meets constraint: reflections on empirical fitness landscapes after Weinreich et al. (2006)" 20 years after a seminal study, I discuss the forces that both constrain evolution + make it possible academic.oup.com/genetics/adv...

I really value: the dynamics of community assembly on 2 contrasting C sources. Daily sampling of communities derived from compost & maintained over 8 wks. No difference in diversity maintained on simple or complex C. AmaZinG. 🙏 all enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...

🌾 Rice feeds more than half the world. This review shows how Prime editing can overcome key limits of other #GenomeEditing approaches, with applications such as improved grain quality, stress resilience and disease resistance. www.frontiersin.org/journals/pla...

The latest in my “what has four billion years of evolution taught us” series. Always free. Always about evolution. Take a look. open.substack.com/pub/profmcin...

Striking charts in this week's Briefing on AI models' values www.economist.com/briefing/202...

A short interview on research assessment and academic reform was published today by Forschung & Lehre. The article is in German, but with an English translation. This forms part of a broader initiative on Academic Renewal that can be found on Substack. www.forschung-und-lehre.de/management/w...

There's a persistent rumor that Python's genomics plots are ugly. It was a real pleasure working on the practical for our Python genomics visualization course and showing that simply isn't true. Follow the repo and stay tuned as we finalize the agenda 👇 github.com/loukesio/dat...

#Python is also a powerful tool for creating stunning scientific visualizations! 🚀 We are exploring how to analyse genomic data and transform complex results into beautiful, publication-ready figures with @bioinformatician.bsky.social 🧬🐍 www.physalia-courses.org/courses-work... #DataVisualisation

If you're still wondering about the slick new functions in dplyr 1.2.0, join me for a "Working smarter with dplyr 1.2.0" redux with R-Ladies Abuja! 📅 Wednesday, 24 June 2026 🕐️ 6pm WAT 🔗 www.meetup.com/rladies-abuj... See you there! ⚒️ #RStats

What does the new EU framework on #NGTs mean for us at KWS? ➡️ After yesterday’s approval in the European Parliament, a two-year phase starts to prepare implementation. 🌱 Then: faster development of more resource-efficient, climate-tolerant crop varieties. ow.ly/ipG150Ze5UV

10 tips for getting better R code from your AI coding agent www.infoworld.com/article/4184... #Rstats

Public money should not flow automatically to journals that fail to meet acceptable standards of editorial quality, transparency and accountability. In this post I ask what a journal accreditation system might look like & how it could work. academicrenewal.substack.com/p/building-a...

LifeSciBench: Evaluating Language Models on Realistic, Expert-Level Tasks in the Life Sciences (PDF): cdn.openai.com/pdf/b4299379... Blog post: openai.com/index/introd...

Multi-omic characterization of nasopharyngeal carcinoma delineates the subtype-specific landscape of response to induction chemotherapy www.nature.com/articles/s4...

This is great (h/t @owenwntr.bsky.social). Incidentally, I wonder if "slop-free" will be the online equivalent of "organic" or "unprocessed food" umap.openstreetmap.fr/en/map/birth...

I want to publicly thank @jcheng5.bsky.social for being willing to write this post, laying out how our AI tooling has evolved (including those eyebrow-raising product names)! 😅 opensource.posit.co/blog/2026-06...

Its going to be fun! Apart from traditional #dataviz we will also learn how to build your own #dataviz agend. Looking forward seeing you there

Join us next week and learn how to turn complex genomic data into clear, publication-ready figures using Python. From exploratory plots to advanced visual analytics with @bioinformatician.bsky.social www.physalia-courses.org/courses-work...

🌾 Speed matters in plant breeding! Developing a new variety takes about 10–12 years. To respond faster to disease pressure and the changing climate, one of the tools we use to speed up breeding is double‑haploid production. Watch how it works 👇 youtu.be/goFaLR_GMVg?...

Dear network ⚽ 𝗧𝗵𝗶𝘀 𝗶𝘀 𝗺𝘆 𝗽𝗿𝗲𝗱𝗶𝗰𝘁𝗼𝗿 𝗳𝗼𝗿 𝘁𝗵𝗲 𝗙𝗜𝗙𝗔 𝗪𝗼𝗿𝗹𝗱 𝗖𝘂𝗽 𝟮𝟬𝟮𝟲, 𝗯𝘂𝗶𝗹𝘁 𝘄𝗶𝘁𝗵 𝘁𝗵𝗲 𝗵𝗲𝗹𝗽 𝗼𝗳 𝗖𝗹𝗮𝘂𝗱𝗲. loukesio.github.io/WorldCup_2026/ I decided to go with a Monte Carlo simulation: instead of predicting a single outcome. #FIFA #ML #AI #WorldCup #dataviz

ETIs are usually framed as mergers among already-existing Darwinian entities. I suggest another route: lineages that generate, from within, a component that becomes part of a higher-level individual. Transmissible cancers reveal the boundary. Human–AI systems may test it. doi.org/10.5802/crbi...

🧠✨Course announcement: AI-Assisted Coding for Bioinformatics with Python 📅 1–2 July - Online In this hands-on course, we’ll explore how to integrate AI into Python-based research in a practical and reproducible way. www.physalia-courses.org/courses-work... #Python #AI

New book "A Primer for Experimental Evolution" with coauthors Michael Rose, Margarida Matos, and Joe Graves. www.worldscientific.com/worldscibook... A compact primer for students and colleagues interested in planning and designing experiments to address questions in evolutionary biology.

Pleased to see this beautiful paper out. Kudos to @jeroenmeijer.bsky.social who took @stevenquistad.bsky.social data and dug deep, revealing a new phage that erupts to astonishing abundance. As theory predicts, the life of SGEs is fuelled by encounters with new hosts www.science.org/doi/10.1126/...

Thrilled that our paper "Eco-evolutionary dynamics of massive, parallel bacteriophage outbreaks in compost communities" is out! 🎉🦠🧬 www.science.org/doi/10.1126/... w/ @paulbrainey.bsky.social, Petros Skiadas, Paulien Hogeweg, @bedutilh.bsky.social

Anthropic has a bunch of (free) online courses covering Claude, Claude Code, the API, MCP, agent skills, and subagents, plus AI fluency tracks for educators, students, and nonprofits doi.org/10.59350/wsh...

I like understanding how ideas for charts come about and it’s interesting to read @owenwntr.bsky.social’s explainer on that local election chart I saw everywhere. #rstats #dataviz

Samples returned from the asteroid Ryugu contain all five canonical nucleobases (A, G, C, T, U). Their presence in Ryugu and Bennu supports the hypothesis that carbonaceous asteroids contributed to the prebiotic chemical inventory of early Earth. http://dlvr.it/TRWtVp ☄️

How to Design Antibodies A step-by-step guide to making de novo binders. www.asimov.press/p/antibody-...

Nice to see this published at @PLoS Comp Bio. Big improvements after peer review and important input from @gsherloc.bsky.social! Hopefully, this tool will be helpful for those interested in using barcodes for detecting new beneficial mutations. journals.plos.org/ploscompbiol...

#ggtree has a relatively steep learning curve. But after looking at a few Python alternatives eg., toytree, ETE, Bio.Phylo it's hard to match its layout versatility. 21 tree variants with just a few lines of code. #rstats #phylogenetics #bioinformatics

Definitely not the biggest problem in the world right now, but constantly installing new versions of RStudio, R and R packages is getting old fast. 😤 #RStats #DataScience

I hope you've found this post helpful. Follow me for more. Subscribe to my FREE newsletter chatomics to learn bioinformatics divingintogeneticsandgenomics.ck.page/profile

Study finds ChatGPT Health did not recommend a hospital visit when medically necessary in more than half of cases. www.theguardian.com/technology/2...

Want to master genomics data visualization with Python? Join our online course with @bioinformatician.bsky.social (15–17 June ) and learn to create publication-quality plots—from volcano and Manhattan plots to phylogenetic trees—using top Python libraries. www.physalia-courses.org/courses-work...

5/ How standard tools behave depends on depth. DESeq2, edgeR, limma-voom with size-factor or TMM normalization handle moderate depth differences fine. But artifacts explode when depth is very low or tightly confounded with condition.

1. phantompeakqualtools still works github.com/kundajelab/... 2. I optimized ROSE for super-enhancer identification. now it finishes within 10mins! It was 12 hours! github.com/crazyhottom... now install via pip!

TSniffer: unbiased de novo identification of RNA editing sites and quantification of editing activity in RNA-seq data link.springer.com/article/10....

Austria's newly famous tool-using cow - maybe it should have been a co-author? "Flexible use of a multi-purpose tool by a cow" - www.cell.com/current-biol...

Nature Genetics: Engineering AI co-scientists for statistical genetics applications www.nature.com/articles/s41... 🧬💻🧪 read free: rdcu.be/eZ2wR

"The changing roles of Escherichia coli" -- a short essay by yours truly. rdcu.be/eVtXT

All you want for christmas is.... transposon mutagenesis! Our new work at @cultivarium.bsky.social screening lots of transposon vectors in lots of bacteria, from @charliegilbert.bsky.social and team. Transposon and promoter modular parts available on Addgene (pooled library will be there soon too)

𝗢𝘂𝗿 𝗔𝗻𝗻𝘂𝗮𝗹 𝗚𝗲𝗻𝗼𝗺𝗶𝗰𝘀 𝗩𝗶𝘀𝘂𝗮𝗹𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗖𝗼𝘂𝗿𝘀𝗲 𝘄𝗶𝘁𝗵 Physalia courses 𝗵𝗮𝘀 𝘄𝗿𝗮𝗽𝗽𝗲𝗱 𝘂𝗽! All course materials are available: 👉 lnkd.in/gTnfFewM You'll find all the code, slides, and resources I used to prepare the course from basic ggplot2 concepts to advanced genomic visualizations using R.

Our final course of the year is a wrap! 🎉 Huge thanks to @bioinformatician.bsky.social and to all the participants who joined us this week to level up their #Genomics #DataViz skills. We can’t wait to see your beautiful figures making their way into papers, posters, and presentations!

💻 Discover all the latest features of Nextflow on Dec 11, , including the new Plugin Registry, workflow inputs & outputs, and static types. Plus, don't miss the opportunity to ask the creator of Nextflow (@paoloditommaso.bsky.social) anything! 🌟 🌟 Register now: hubs.la/Q03W12B90

Join our online course "Genomic Data Visualisation with R" on Dec 15-17. Learn to create impactful visuals for genomics. More info and registration: https://www.physalia-courses.org/courses-workshops/genomic-data-viz/ #course

Human-mediated land-use and climate change occur simultaneously, but how do they interact to shape adaptive dynamics? Super excited to share the first paper from the Kreiner lab, led by postdoc extraordinaire @rpineau.bsky.social

Labour finding a monkey's paw in early 2020: "We may be 20 points behind now but we'll halve it in five years..."