Congratulations @damien-glon.bsky.social ! Very happy to be involved in this study with @frl-lab.bsky.social ! 🔥

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🎉 Excited to share the publication of our study in @bloodjournal.bsky.social , highlighted by an accompanying editorial! 📄 Article: doi.org/10.1182/bloo... 🖋 Editorial: doi.org/10.1182/bloo...

Graft failure remains challenging, with CI of grade 2 to 4 acute GVHD, but not grade 3 to 4, being significantly higher after PTCY. buff.ly/7VcLjgd #hemesky #transplantation

@quentinriller.bsky.social, @frl-lab.bsky.social et al. present the first case of biallelic CHUK mutations disrupting IKKα kinase function, broadening the understanding of non-canonical NF-κB defects rupress.org/jem/article/... 📘 In Genes & Immunity collection: rupress.org/jem/collecti... #HKS2025

Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans @jem.org‪ @quentinriller.bsky.social @frl-lab.bsky.social doi.org/10.1084/jem....

Thrilled to share our latest in @jem.org! 🚨 A single patient with syndromic immunodeficiency led us to uncover that biallelic point mutations in the IKKα kinase domain disrupt the non-canonical and partially the canonical NF-kB pathway activation. Dive into the details! 🧬 #NFkB #Immunology