Today, we’re launching a new company, ALTx Therapeutics. Founded by Simon Boulton, the company will develop the first precision therapies targeting ALT cancers, in partnership with Slingshot Therapeutics Limited and @crhorizons.bsky.social. Find out more ➡️ www.crick.ac.uk/news/2026-02...

🚀 New preprint alert! We uncover SLFN11 as a molecular gatekeeper that restricts alternative lengthening of telomeres (ALT) by sensing telomere-associated replication stress and triggering apoptosis. 📄 Read the manuscript here: www.biorxiv.org/content/10.1...

Have a read of our latest work on a mechanism by which SLFN11, a gene mutated in 50% of cancers, can be activated. Implications for why cancers don't want functional SLFN11 around

Merry Boulton Lab Retreat! Great fun team building and going over some hot topics in DDR/chromatin/immune biology. Same again next year please! @mattdnewton.bsky.social @ssegurabayona.bsky.social @federicaraguseo.bsky.social @claralnovo.bsky.social

Thank you @promegauk.bsky.social for the Christmas hamper

Happy to share a review written with the wonderful @jstingele.bsky.social on transcription-coupled DPC repair, featuring an overview of new methods, close comparison with TC-NER, comments on clinical implications and plenty of discussion of the unknowns. www.cell.com/trends/cell-...

“In this Review, we discuss #telomere protection, maintenance and damage. We highlight the differences between #human and #mouse telomere biology that may contribute to discrepancies between human #diseases and mouse models.” #telomerase #aging www.nature.com/articles/s41...

Here is a brief summary of academic journals and news account. Please help me add more accounts to this list! go.bsky.app/hCfhqn

Good thing the #CBIAS2024 organizers sent a plan to reach the @thecrick.bsky.social , I almost missed the tiny building

Here’s my spreadsheet of starter packs (>80!) related to broadly ‘mechanistic biology’ plus some intriguing extras Complete with collective nouns I’ve been tracking these but now can’t keep up Hope it’s helpful 2/2 docs.google.com/spreadsheets...

First post is to introduce Pablo to bluesky. Science will follow.

GS II is here! Please follow the newly arrived folks, and comment/DM to be included! go.bsky.app/VeCmq6

ok, I tried to make a starter pack on genome stability/DNA replication/DNA repair etc. Sorry if I couldn't find someone, please nominate yourself and your colleagues in comments or DMs, looking forward to connecting with everyone! go.bsky.app/9jdDNxG

Hi BlueSky! It's great to be here. Here's a handy Starter Pack of DNA repair & genome stability groups that I found so far go.bsky.app/NvFWKvL