Jake Vogel
@jwvogel.bsky.social
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Assistant Professor @Lund University | Neurodegenerative disease | Neuroimaging | AI | Multi-omics |
reposted by
Jake Vogel
8 days ago
New paper in Nature Aging led by PhD student Lina Lu! We mapped how APOE ε4 and APOE ε2 shape molecular changes in blood and cerebrospinal fluid across Alzheimer’s disease.
www.nature.com/articles/s43...
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Proteomic signatures of the APOE ε4 and APOE ε2 genetic variants and Alzheimer’s disease - Nature Aging
Apolipoprotein E (APOE) is the strongest genetic influence in Alzheimer’s disease (AD). Compared to the most frequent allele, ε3, the ε4 allele increases AD risk, and the ε2 allele is protective. Here...
https://www.nature.com/articles/s43587-026-01123-0
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reposted by
Jake Vogel
about 1 month ago
New publication out in Brain! 📢We developed a data-driven multimodal biomarker framework to characterize a memory clinic cohort based on the presence, extent, and sequence of common pathologies. This framework may support diagnosis and trial selection. 🔗https://doi.org/10.1093/brain/awaf411
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Incredibly excited that the lab's first papers is now published! We use AI to simultaneously predict multiple neurodegenerative disease diagnoses from plasma proteomics. Congrats
@anlijuncn.bsky.social
!
#MedSky
#neuroskyence
#neurosky
#alzsky
#compneuro
#ai
#datascience
#bioinformatics
#neurology
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about 2 months ago
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Going to ADPD? Come see our work! We would love to share it with you and chat about it if you are interested. See below for a schedule of our sessions, which cover fMRI, proteomics, transcriptomics and AI, led by brilliant lab members
@anlijuncn.bsky.social
@jorittmo.bsky.social
and others
2 months ago
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reposted by
Jake Vogel
Toomas Erik Anijärv
3 months ago
I couldn't find a tool to plot different
#neuroimaging
data in one consistent style, so I made one! Meet yabplot (yet another brain plot) - a
#Python
package for (sub)cortex & tracts.🧠 - Simple API - Built-in atlases - Custom atlas support 🔗
github.com/teanijarv/ya...
(drop a ⭐️!)
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#MedSky
#neuroskyence
#neurosky
#alzsky
#compneuro
#datascience
#neurology
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3 months ago
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reposted by
Jake Vogel
Mark A. Hanson
6 months ago
We wrote the Strain on scientific publishing to highlight the problems of time & trust. With a fantastic group of co-authors, we present The Drain of Scientific Publishing: a 🧵 1/n Drain:
arxiv.org/abs/2511.04820
Strain:
direct.mit.edu/qss/article/...
Oligopoly:
direct.mit.edu/qss/article/...
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Jake Vogel
Anders Eklund
8 months ago
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reposted by
Jake Vogel
9 months ago
🚨New paper alert! Our study led by
@teanijarv.bsky.social
investigated why some individuals with Alzheimer’s disease (AD) develop hemispheric asymmetry in tau pathology and what drives this phenomenon. Out now in Nature Communications! 🔗Full article:
doi.org/10.1038/s414...
A thread🧵👇
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Hemispheric asymmetry of tau pathology is related to asymmetric amyloid deposition in Alzheimer’s Disease - Nature Communications
Asymmetrical distribution of tau pathology in Alzheimer’s disease is linked to asymmetrical amyloid-beta deposition, not reduced brain connectivity, suggesting regional vulnerability plays a key role ...
https://doi.org/10.1038/s41467-025-63564-2
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Really compelling evidence in humans for network propagation hypothesis of tau spread: individualized connectivity helps resolve individualized tau patterns.
#MedSky
#neuroskyence
#neurosky
#alzsky
#compneuro
#ai
#datascience
#bioinformatics
#neurology
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8 months ago
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reposted by
Jake Vogel
Pavan Chaggar
9 months ago
I'm thrilled that our paper "Personalised regional modelling predicts tau progression in the human brain" is finally published in PLoS Biology! Here's a short thread about the main findings of the paper...
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reposted by
Jake Vogel
Adrian Liston
9 months ago
🧵How to write and manage your first research budgets The point of funding is to convert it into quality research. A well-spent research budget should fund the idea it was raised on, plus revision experiments, plus preliminary data for the next grant. So you need to spend, while avoiding waste.
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Jake Vogel
Colleen Steckel
10 months ago
We need higher resolution brain scans for people with
#MyalgicEncephalomyelitis
. This is an exciting development that could lead to better clinical understanding for many of us.
#Neuroskyence
#medsky
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Jake Vogel
David H Friedel Jr
10 months ago
If clinically validated, it could democratize access to advanced imaging, improve neuro-diagnostic precision, and streamline both research and patient care without requiring costly hardware upgrades. A win for everyone
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‼️NEW PREPRINT‼️ What if you could take a normal 3T T1w MRI and make it look like it was acquired from a 7T scanner? That's exactly what we do using AI in our new preprint! Link:
arxiv.org/abs/2507.13782
#neuroskyence
#neurosky
#compneuro
#AI
#datascience
#neurology
#mrisky
#neuroimaging
10 months ago
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Incredibly excited for this new work from our lab. We test the potential of AI-based neurodegenerative disease diagnostics using plasma proteomics data from n>17,000 people, led by the brilliant and indefatigable
@anlijuncn.bsky.social
Check it out!👇
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10 months ago
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Jake Vogel
Alex Fornito
12 months ago
Have recent changes led to uncertainty in your future scientific career? Wonder it's like in Australia? Good news! Monash's is seeking to hire talented EMCRs from other countries. Come join a wonderful community of brain mappers & modellers!
www.monash.edu/research/eme...
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EMERGE
https://www.monash.edu/research/emerge
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‼️Preprint alert‼️ Star PhD student
@jorittmo.bsky.social
uses functional gradients as a framework to study longitudinal brain functional reorganization in aging and AD. Check out the thread 👇🏼
#MedSky
#neuroskyence
#neurosky
#alzsky
#compneuro
#MRI
#neuroimaging
#neurology
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12 months ago
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reposted by
Jake Vogel
Benjamin Kay
about 1 year ago
My med school textbook says stimulants like Ritalin treat hyperactivity by “stimulating” the brain’s attention and cognitive control systems. We studied children taking stimulants in the ABCD Study, and the largest differences were actually in arousal and reward networks! Check out our
preprint
!
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Jake Vogel
Étienne Vachon-Presseau
about 1 year ago
Our new @NatureComms paper: We used UK Biobank data (n≈193K) to build ML models predicting tinnitus presence (driven by hearing health) and severity (influenced by mood, neuroticism & sleep). A simple 6-item POST questionnaire forecasts 9-yr outcomes.
shorturl.at/4AF4P
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Tinnitus risk factors and its evolution over time - Nature Communications
Improving tinnitus prevention and clinical management by identifying key associated risk factors is crucial. Here, the authors use machine learning in a large cohort to identify key predictors of tinn...
https://shorturl.at/4AF4P
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reposted by
Jake Vogel
Linden Parkes
about 1 year ago
Excited to share the first major piece of work and preprint from my lab! Led by Jason Kim! 🥳🎉🤘
www.biorxiv.org/content/10.1...
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reposted by
Jake Vogel
about 1 year ago
‼️New preprint! We are happy to share our latest work led by
@teanijarv.bsky.social
investigating why tau pathology in AD often accumulates more in one hemisphere of the brain than the other. Check out 🔗https://biorxiv.org/content/10.1101/2025.04.15.648728v1 or dive into the details below👇
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reposted by
Jake Vogel
about 1 year ago
🧠Exciting new findings from a great collaboration between the BioFINDER study and the talented
@xiaoyucaly.bsky.social
from
@jwvogel.bsky.social
group!! In their preprint, they show that tau presence and tau load are guided by unique brain mechanisms. Dive into the details here 👇
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I am so very proud announce my lab's first preprint!!
@xiaoyucaly.bsky.social
delves into the mechanisms driving tau distribution: * Tau sequence driven by connectivity dynamics * Tau load driven by local factors Check out her thread below
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about 1 year ago
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