I'm thrilled that our paper "Personalised regional modelling predicts tau progression in the human brain" is finally published in PLoS Biology! Here's a short thread about the main findings of the paper...

I am so very proud announce my lab's first preprint!! @xiaoyucaly.bsky.social delves into the mechanisms driving tau distribution: * Tau sequence driven by connectivity dynamics * Tau load driven by local factors Check out her thread below

🧠New preprint! What drives tau, the pathological protein in AD, to spread? We found that WHERE tau appears and HOW MUCH accumulates are governed by different mechanisms. Check it out:
www.biorxiv.org/content/10.1...
 #MedSky #neuroskyence #neurosky #alzsky #compneuro #MRI #neuroimaging #neurology

🚨REVIEW We have written a review on the emerging topic of nonequilibrium, irreversible dynamics in the brain. Now out on the arXiv: arxiv.org/abs/2504.12188 We introduce the relevant mathematical frameworks, discuss recent interesting results, and look to the future of this research direction!

Modelling cerebrovascular pathology and the spread of amyloid beta in Alzheimer’s disease: royalsocietypublishing.org/doi/10.1098/... #ProcA #Alzheimers #biophysics

In this paper, we connect local damage to brain vasculature to global progression of toxic proteins leading to neurodegenerative diseases. royalsocietypublishing.org/doi/epdf/10.... We identify situations where disease initiation can be caused by focal hypoperfusion following vascular injury.

🚨PERSPECTIVE We have written a perspective calling for a holistic approach to mathematical modelling for biological systems - it now out on the arXiv: arxiv.org/abs/2503.20511 A thread 🧵

🚨 NEW PAPER ALERT! After such a long journey, I am so glad to see this published in @PNASNews: pnas.org/doi/10.1073/... Big thanks to @leonardobonetti.bsky.social, Gemma Fernandez-Rubio, Peter Vuust, Gustavo Deco, Morten Kringelbach, Renaud Lambiotte and @alaingoriely.bsky.social A thread...

Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness academic.oup.com/brain/articl...