Archaeal and eukaryotic MCM rings sequentially melt DNA for replication initiation @natcomms.nature.com #microbiology #archaea #eukaryotes #MicroSky doi.org/10.1038/s414...

I wrote a piece for the Yale Review on AI and "jagged intelligence". (Note: headline was not written by me.) yalereview.org/article/mela...

Reconstitution of Archaeal Membrane Lipid Biosynthesis in Bacterial and Eukaryotic Hosts #microbiology #archaea #bacteria #eukaryotes #MicroSky doi.org/10.1002/cbic...

Very happy to share our latest publication in Nat. Commun. www.nature.com/articles/s41... It was a great collaboration with @ifremer.bsky.social, @cbitoulouse.bsky.social and @pasteur.fr. We discovered a new hibernation factor in Archaea binding to the ribosome in three different conformations !

A new microfluidic device measures cell elasticity rapidly and reliably, offering potential improvements in disease diagnosis and prognosis by analyzing mechanical changes in cells. doi.org/hbzg4j

Second up tomorrow, April 22nd at 10AM EST / 4PM CET, Katy Weber will tell us about her interesting work to mechanistically characterize electron transfer in a reductase protein from Haloferax volcanii!! Visit the link in our bio for more info on how to join our community!!

Structural basis of transcription-coupled RNA damage by incorporation of oxidized ribonucleotides | PNAS www.pnas.org/doi/full/10....

🔈Paper out! We turned the most fascinating phage host-switch mechanism, diversity-generating retroelements, into a programmable mutagenesis tool, DGRec. You can perform targeted hypermutation of any 50-200bp sequence directly in vivo in E. coli www.nature.com/articles/s41...

Archaea hit prime time: www.bbc.co.uk/programmes/m...

We should all do our part to join Brian in ending genetics essentialism. I give a lecture at Pitt to the new PhD students entitled "There is no such thing as wild-type." I blogged about this years ago and it's part of my teaching statement. Long road, team effort✊🏻 micropopbio.org/blog/2018-07...

Integrative Omics and Network Biology Reveal Transcriptional Changes of Amino Acid Transport in Arabidopsis Susceptibility to Pseudomonas syringae https://www.biorxiv.org/content/10.64898/2026.03.25.714176v1

#NatMicroPicks Same destination, different routes 🍄🧫🧪 Following 10,000 generations, parallel evolution occurred in separate yeast species, but took different genetic routes driven largely by transcriptomic and trans‑regulatory differences. #MicroSky www.nature.com/articles/s41...

New #AI model could cut the costs of developing protein drugs. #science #news www.lifescience.net/news/7008/ne...

Having a hard time keeping up with the fast-moving field of origin of eukaryotes/Asgards archaea? Our new perspective article can help, we review the status of research over the last decade and where it's going. The archaeal roots of eukaryotic life www.pnas.org/doi/10.1073/...

New paper from my 2nd PostDoc is now published in The ISME Journal by @isme-microbes.bsky.social! #Sulfur disproportionation occurs globally across anoxic habitats & has multiple mechanisms of independent evolutionary origin academic.oup.com/ismej/advanc... #Bacteria #Microbes #Evolution #DeepSea

Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating). A brief 🧵 (carried over from the old place)

CRISPR spacers reveal diverse and abundant Thermococcales viruses in hydrothermal vents www.researchsquare.com/article/rs-8...

Openness means more than access. That's why we encourage submissions of Replication Studies. Learn about publishing your replication study with us in our author guide: buff.ly/rcI0oAY

One of the biggest questions in biology is how complex cells evolved about 2 billion years ago. Here's my new story on how scientists are solving the mystery of eukaryotes like us. Gift link: nyti.ms/4qMbo22

Nice review by Urmila Chadayammuri of Maria Popova's new book Traversal. I have reviewed it for @science.org (coming soon) and my take has a lot of overlap with Urmila's. In short, it is a strange beast and all the better for that. www.nature.com/articles/d41...

🧬 A major data reanalysis in December's most-read Genetics paper uncovers thousands of previously hidden protein-coding regions in human and mouse genomes: buff.ly/6TsX3ct

Archaeal G-quadruplexes: a novel model for understanding unusual DNA/RNA structures across the tree of life url: academic.oup.com/nar/article/...

A web-based atlas for exploring post-transcriptional regulation in the archaeon Sulfolobus acidocaldarius #microbiology #archaea #MicroSky #ArchaeaSky @asm.org journals.asm.org/doi/10.1128/...

How the ocean’s hydrothermal systems made the first life on Earth possible