Kevin Wasko
@kevinwasko.bsky.social
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PhD candidate @ UC Berkeley Characterization & delivery of CRISPR proteins
reposted by
Kevin Wasko
Erin Doherty
4 days ago
Now online at
@nature.com
we show how the Panoptes defense system protects against viruses that attempt immune evasion - and expands our understanding of the role of oligonucleotides in immunity. Check out this work co-led with
@benadler.bsky.social
here:
www.nature.com/articles/s41...
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A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature
Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.
https://www.nature.com/articles/s41586-025-09569-9
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reposted by
Kevin Wasko
Owen Tuck
2 months ago
Excited to finally share this work! We noticed a pair of genes - a nuclease and a protease - shuffles between antiviral systems. We show how proteolysis activates the nuclease, triggering defense in known and unknown immune contexts.
tinyurl.com/2uwwy4ty
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Recurrent acquisition of nuclease-protease pairs in antiviral immunity
Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin...
https://tinyurl.com/2uwwy4ty
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