A must-read, landmark paper by @lisaschweizer.bsky.social - hands down one of the most accomplished scientists I know. Congratulations👏 @mannlab.bsky.social @lengyel-ovca-lab.bsky.social bsky.app/profile/mann...

Our paper on ovarian cancer #LGSC is out in @Cancer_Cell. Using deep visual proteomics #DVP and spatial transcriptomics, we mapped how non-invasive tumors become deadly ovarian disease, and found a promising new treatment combination. www.cell.com/cancer-cell/...

Since April, @tnordmann.bsky.social has been leading a research Group @mpibiochem.bsky.social. He has now been awarded the prestigious Oscar Gans Prize by the German Dermatological Society. Congratulations and welcome! #award #dermatology #proteomics @mannlab.bsky.social

In patients with diffuse intrinsic pontine glioma, a rare, fast-growing and fatal pediatric brain tumor, local delivery of B7-H3 targeting CAR T cells was feasible and well tolerated with a median overall survival of 19.8 months, according to a trial reported in Nature Medicine. #MedSky 🧪

Our mipDVP workflow integrates 22-marker imaging with Deep Visual Proteomics to spatially map cell-type proteomes in hot/cold tumors, revealing distinct immune landscapes, macrophage barriers, T cell adaptations to hypoxia & tumor heterogeneity. Online in Molecular Cell. doi.org/10.1016/j.mo...

My favorite books, 2024

Looking forward to a fabulous 2025, full of happiness and scientific achievements! 🔬💫

Spatial proteomics is Method of the Year 2024 @naturemethods.bsky.social!🎉🤩 Grateful to share our perspective on spatial proteomics with the great Matthias Mann and Andreas Mund, alongside inspiring colleagues shaping this exciting field - this is just the beginning 💫 www.nature.com/articles/s41...

www.nature.com/articles/s41... Commentary by @tnordmann.bsky.social Editorial @naturemethods.bsky.social www.nature.com/articles/s41...

Spatial proteomics is Method of the Year 2024 @naturemethods.bsky.social!🎉🤩 Grateful to share our perspective on spatial proteomics with the great Matthias Mann and Andreas Mund, alongside inspiring colleagues shaping this exciting field - this is just the beginning 💫 www.nature.com/articles/s41...

After long-time review, #nanoSPLITS is finally published. I am deeply grateful to my colleagues who made this work possible, especially @cajunscience.bsky.social. I am also grateful to the support of our single-cell proteomics community during the peer review on Nature Communication!

A bench-to-bedside targeted therapy story! Fatal disease ➡️ patient samples ➡️ deep proteomics ➡️ find target (jak/stat) ➡️ realize drugs exist ➡️ try drugs in lab ➡️ it works! ➡️ give drugs to patients ➡️ holy cow it actually works!!!! ➡️ save lives. This is the dream. Nice work @tnordmann.bsky.social

Wow—one of the most impressive bench-to-bedside stories you’re ever going to see out today @Nature Spatial proteomics of potentially fatal toxic epidermal necrolysis/Stevens-Johnson Syndrome drug reactions identifies JAK/STAT pathway inhibition as effective therapy! www.nature.com/articles/s41...

Science twitter is dead! Long live science twitter! 🦋

First BlueSky post :)

The Dawn of Spatial Medicine Until now, spatial omics was used to understand human biology. That changed when it saved lives of patients with a fatal skin condition. In the new Ground Truths erictopol.substack.com/p/the-dawn-o...