A very interesting tool with an unexpected finding from @krishnanyamuna.bsky.social and collaborators. Do read, enjoy, and use!

Organelles do NOT have a single uniform pH. And if you think they must, because “protons diffuse fast,” this paper is for you. A thread on why that assumption is wrong; and what we found instead. 🧵 1/n

Enjoying a visit @DBT_inStem & @ncbsbangalore.bsky.social Beautiful campus, great Science, amazing students Thank you @InamdarManeesha for the opportunity and @kvijayraghavan.bsky.social for a stimulating conversation

#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST! We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease. Spread the word and join the discussion!

I set out to review the evolution of eukaryotic intracellular traffic, but along the way a new hypothesis came into focus: maybe the earliest membrane carriers were tubules, not coated vesicles! New preprint: ecoevorxiv.org/repository/v... Here’s the idea. 🧵

A very Happy 2025 to all here and outside.